All About Vitamins: Vitamin B5 Deficiency and Risk of Auto immunity

Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may have an implicated effect on promoted immune system in production of proinflammatroy status, a renowned institute study suggested.

In the study of vitamin D replacement slowly induced a secondary pantothenic acid deficiency with oral administration of vitamin D + B100 (100mg of all B vitamins except 100mcg of B12 and biotin and 400mcg of folate) to over 1000 neurology patients, researchers found that the vitamin D supplement reduced expression of pro inflammatry cytokins in improved sleep, reduced pain and unexpected resolution of bowel symptoms.

Vitamin D-supplement ameliorated vitamin B5 deficiency also created an intestinal environment that favors the return of the four specific species, Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria through regulating inflammation of intestinal system.

Dr. Gominak SC, also said, "... Improved sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, increased arthritic pain and widespread "pro-inflammatory" effects on the immune system" and "Pantothenic acid deficiency also decreases available acetylcholine, the neurotransmitter used by the parasympathetic nervous system".

According to Dr. Tautt J. in the experiments carried out to test the length of time necessary to induced vitamin deficiency by removing vitamins from the diet or by giving the rabbits antibiotics of different activity spectrum when the animals kept on a diet without vitamins, said, "(observation by microbiological assay) the time after which changes in vitamin levels developed as well as the intensity of changes differ, depending on the experimental model used, but the sequence of vitamin disappearance from the organism is always the same. The first to disappear were vitamins B1, followed by vitamin B6 and pantothenic acid"

Taking altogether, vitamin B5 deficiency induced by diet deficiency or antibiotics stimulated Immune expression of pro inflammatory cytokins in various types of disease.



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Sources
(1) Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity by Gominak SC1.(PubMed)



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.