Herbal Cat's claw Kills 90% of Breast Cancer Cells in Vitro

Scientists may have found a functional herb which has the potential to treat breast cancer without including any side effects, some studies suggested.

Most breast cancer irregular cells growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

At the later stage, after colonizing the most parts of breast tissue, malignant cells can travel a distance far the way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.


In Canada, the risk of getting invasive breast cancer during the lifetime before the age of 90 of a woman is 1/11.

The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.

However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.

According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.


The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.


The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.

Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.


Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).

Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line

Furthermore, the Cat 's claw extracts a strong in antimutagenic activity by restoring the cell DNA to a healthy level.

Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking the cell division through cell cycle arrest.


Moreover, at the concentration of 100 mg/ml of two active fractions isolated from Cat's claw inhibited 90% of breast cancer cells in MCF7.

These results suggested Cat's extract and its active fractions may be considered secondary therapy for treatment of breast cancer.

However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)