Phytochemical Sinigrin Protects the Neuron Against Toxicity

Sinigrin may be used as a natural and bioactive compound for the treatment of neurotoxicity, according to studies.

Neuroprotection is anything used or intake for the protection of neurons in the brain.

Neurotoxicity is a condition in which the structure or function of the central and/or peripheral nervous system have been damaged due to the presence of biological, chemical or physical toxins.

Neurons are the cells in the brain with a unique function in which the information is being received processed, and transmitted from cell to cell, muscle, or gland cells.


Neuron toxicity can occur to any parts of the brain, depending on the types of neurotoxin. Symptoms of neurotoxicity are also depending on the neurons specific functions, the neurotransmitters affected.

According to the Integrative Psychiatry, symptoms may include

* Brain fog – loss of mental focus, ADD, ADHD, impaired memory, poor decision making;

* Insomnia – difficulty falling asleep, staying asleep, or both

* Pain – migraines, fibromyalgia.

* Obesity – metabolic syndrome, insulin resistance, and diabetes.


These results clearly suggested that neurotransmitters imbalance can cause a wide range of diseases.

Researchers on finding a natural compound which processes neuroprotective effects examined the Allyl isothiocyanate (AITC), presented in Wasabia japonica (wasabi), and an aliphatic isothiocyanate derived from the precursor sinigrin on neurotoxicity.

Pretreatment with AITC significantly inhibited the production of free radical NO induced by nitric oxide synthase (iNOS) and protein (COX-2) associated with inflammation.


Injection of AITC decreased the expression of proinflammatory cytokines such tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2) during the acute phase of infection.

Furthermore, AITC inhibited the nuclear factor NF-κB induced the oxidative stress and the pathway involved in directing cellular responses.

Moreover, AITC also protected the microglia damage induced by overexpression of pro-inflammatory cytokine TNF-α.


The results strongly suggested that AITC exerts anti-neuroinflammatory effects on microglial cells, which may have clinical significance in neurodegeneration.

Taken altogether, sinigrin a bioactive ingredient may be considered a functional supplement for the prevention and treatment of neuro-toxicity, pending to the confirmation of large sample size and multicenter human study.


However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling by Subedi L1, Venkatesan R2, Kim SY. (PubMed)