Phytochemical Sinigrin Improves the Metabolic Parameters in Patients with Types 2 Diabetes, Cardiovascular Diseases

Metabolic parameters are a measurable factor used for the prediction of type 2 diabetes, heart diseases, and stroke.

Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are important considerations used for the treatment of patients with type 2 diabetes and nephropathy.

Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol and potassium level in the bloodstream, respectively.

In other words, the levels of lipid and carbohydrate homeostasis, esterified and total cholesterol, free fatty acids and triacylglycerols are considered measurable factors for the onset and treatment of types 2 diabetes and cardiovascular diseases.

For example, in a retrospective study used a national electronic database to examine the metabolic parameter of Malay patients with type 2 diabetes, researchers in the comparison of some of metabolic parameters traced before, during and after Ramadan, found that systolic blood pressure, low‐density lipoprotein cholesterol and triglycerides showed insignificant change in all participants, except blood glucose which was most affected during Ramadan.

By knowing the parameters that affect the patients has been found to enhance the management and treatment in patients with types 2 diabetes.

Researchers in seeking a potential natural compound for the improvement of metabolic parameters examined the sinigrin (SIN) and allyl isothiocyanate (AITC) preventive and medicinal effect.

The study included the injection of glucosinolate sinigrin 50 μmol/kg b. w./day and its degradation product allyl isothiocyanate 25 μmol/kg b. w./day and 50 μmol/kg b. w./day in an animal rat model in vivo after their single (4 h) and 2 weeks oral administration.

AITC alone after 4 h of its ingestion caused liver triacylglycerols increment at both doses and glycemia only at the higher dose.


Interestingly, multiple SIN treatment showed its putative bioconversion into AITC.
SIN and AITC multiple administration strongly disturbed lipid and carbohydrate homeostasis, increasing esterified and total cholesterol, free fatty acids and lowering triacylglycerols in the blood serum.

Additionally, AITC at both doses elevated insulinemia and liver glycogen enhancement.

The finding strongly suggested that SIN and AITC improve metabolic parameters through multi-directions including liver, pancreas, and intestine.

Dr. Okulicz M, the lead scientist said, "This effect is potentiated with a time of action of the examined compounds, whose influence is rather adverse for the majority of metabolic pathways (liver steatosis at the short duration and insulinemia, cholesterolemia at long time treatment)".

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be used to improve metabolic factors against the onset of metabolic syndrome, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats by Okulicz M. (PubMed)
(2) Metabolic parameters in type 2 diabetic patients with varying degrees of glycemic control during Ramadan: An observational study by Melanie Y. L. Siaw, 1 Daniel E. K. Chew, 2 Matthias P. H. S. Toh, 3 Darren E. J. Seah, 4Ruimin Chua, 1 Jielin Tan, 1 Evonne Y. Q. Lee, 5 Sui Yung Chan, 1 and Joyce Y. C. Lee. (PubMed)