Diabetes is a chronic low-grade inflammatory condition associated with the insufficient insulin entering bloodstream due to the reduced numbers of beta cells in the pancreas or insulin receptor site clogged up by fat or cholesterol.
Beta cells in the pancreas are the endocrine portion of the pancreas, made up 50–70% of the cells in human islets that produce insulin.
Beta cells secret stored insulin in response to the spikes in blood glucose concentrations.
On the other hand, when the blood glucose levels drop, the alpha cells in the pancreas release glucagon in stimulating the liver cells to release glucose into the circulation.
In short, cells in pancreas protect our body system by modulating the levels of blood glucose for the best to our body
Insulin receptor site is a protein that binds to insulin and passes its message into the cell in which the cells convert glucose to energy.
There are many risk factors associated with the risk of diabetes, including diseases associated with insulin resistance such as age, family history, ethnicity diseases associated with insulin resistance such as polycystic ovary syndrome and obesity, physical inactivity, and gestational diabetes.
Out of many risk factors associated with the onset of type 2 diabetes, some researchers suggested that the rapid rise of type 2 diabetes in the Western world may be correlated to the promotion of high-fat diet over past many decades.
Dr. David Hefner, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes. That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods. "It's the entirety of the diet that's important," Dr. Frank B. Hu, the study's lead author, was reported as saying in The New York Times".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a potential compound or whole food for the treatment of diabetes with no side effects, researchers analyzed the ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial included 70 type 2 diabetic patients randomly assigned into ginger group consumed 1600 mg ginger and control group consumed 1600 mg wheat flour placebo daily for 12 weeks.
Ginger showed a significant effect in almost all parameters associated with diabetes including reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with the placebo group (p < 0.05).
However, there were no significant differences in HDL, LDL, and TNFα between two groups (p > 0.05).
PGE₂ and TNFα are hormone and protein involved the production of proinflammatory cytokines.
In other words, ginger protects patients with diabetes against the onset of complications.
Dr. the lead scientist said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered as an effective treatment for the prevention of diabetes complications".
Furthermore, in a randomized double-blind placebo-controlled trial of 64 patients with DM2 who were assigned to ginger or placebo groups (receiving 2 g/d of each), researchers also found that injection of ginger exerts a strong anti-diabetes activity by significantly lowered the levels of insulin, LDL-C, TG and the HOMA index (3.9 ± 1.09 versus 4.5 ± 1.8; p = 0.002) in comparison to the control group, similar to those of aforementioned study.
Based on the results, researchers suggested, "ginger supplementation improved insulin sensitivity and some fractions of lipid profile in DM2 patients. Therefore it may be considered as a useful remedy to reduce the secondary complications of DM2".
Take all together, ginger may be considered a functional alternative for the prevention of diabetic complications and treatment of diabetes, pending to the confirmation of large sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner (PMC)
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