All About Minerals: Magnesium: Serum magnesium level in preterm labour

By Kyle J. Norton.


Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).

Magnesium: Serum magnesium level in preterm labour

Preterm labour, (PTL) defined as labour after 28 weeks but before 37 completed week of gestation, is an ill omen for our country as the incidence is 5-10% leading to 70-80% of perinatal deaths. According to the study by the Indira Gandhi Institute of Medical Sciences, varied hypomagnesemia was observed in Preterm labour cases (1.47 mg/dl +/- 0.22 S.D.), normal value of serum magnesium was found in normal non-pregnant ladies and slightly low value were observed in pregnant ladies of same gestational age. Age and parity had no significant effect on serum magnesium level in our study. As far as socio-economic study is concerned, it was found to be higher in high socio-economic group and low in lower group. Thus from this study it can be concluded that estimation of serum magnesium in pregnancy may prove to be a valuable tool in predicting preterm onset of labour(5).

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Sources
(5) http://www.ncbi.nlm.nih.gov/pubmed/15022938

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Magnesium Pathophysiology and therapy of magnesium deficiency in pregnancy

By Kyle J. Norton.


Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).

Magnesium Pathophysiology and therapy of magnesium deficiency in pregnancy

In the study to determine serum magnesium(Mg)-levels in 67 pregnant women in late pregnancy. 42 gravidae complained of nightly muscle cramps; 21 of them received 1.8 g monomagnesiumaspartate twice daily per mouth for 4 weeks, found that serum Mg-levels were lower in pregnant women as compared to a control group of non pregnant women. Gravidae complaining of muscle cramps had significantly lower serum Mg-levels than women without muscle cramps. The administration of Mg was associated with a significant rise in serum Mg-levels as early as 2 weeks after the initiation of therapy.The Our study indicates that nightly muscle cramps during pregnancy might be a sign of a latent magnesium deficiency which can be influenced by oral magnesium(4).

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Sources
(4) http://www.ncbi.nlm.nih.gov/pubmed/6891868

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Magnesium- The effect of oral magnesium substitution on pregnancy-induced leg cramps

By Kyle J. Norton.


Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).

Magnesium- The effect of oral magnesium substitution on pregnancy-induced leg cramps

In the study to to determine whether women with pregnancy-related leg crampswould benefit from oral magnesium supplementation, indicated that serum magnesium levels in these patients were at or below the lower reference limit, as is also often the case in healthy pregnant patients. Oral magnesium substitution decreased leg cramp distress (p < 0.05 compared with the placebo group, p < 0.001 compared with initial complaints), but did not significantly increase serum magnesium levels, excess magnesium being excreted as measured by an increase in urinary magnesium levels (p < 0.002). Oral magnesium supplementation seems to be a valuable therapeutic tool in the treatment of pregnancy-related leg cramps(3).
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Sources
(3) http://www.ncbi.nlm.nih.gov/pubmed/7631676

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Magnesium in Clinical aspects and treatment of calf muscle cramps during pregnancy

By Kyle J. Norton.


Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).

Magnesium in Clinical aspects and treatment of calf muscle cramps during pregnancy
According to the study by Riss P, Bartl W, and Jelincic D., muscle cramps were noticed most often in the second half of pregnancy. Gravidae with muscle crampswere on the average older and of higher parity; there was no relationship between muscle cramps and complications during pregnancy or unfavorable fetal outcome. In an uncontrolled therapeutic trial 21 women with muscle cramps received 1,8 g monomagnesium-aspartate twice daily per mouth for 4 weeks. 21 women with muscle cramps had no therapy. 4 weeks after the initiation of magnesium therapy 19/21 women were free of symptoms, compared to only 7/21 patients in the control group. Muscle cramps during pregnancy do not have to be considered a risk factor; they can be significantly improved by the administration of oral magnesium(2).
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Sources
(2) http://www.ncbi.nlm.nih.gov/pubmed/6553557

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Magnesium for skeletal muscle cramps

By Kyle J. Norton.


Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).

Magnesium for skeletal muscle cramps
Skeletal muscle cramps are common and often presented to physicians in association with pregnancy, advanced age, exercise or disorders of the motor neuron (such as amyotrophic lateral sclerosis). In a andomized controlled trials (RCTs) of magnesium supplementation (in any form) to prevent skeletal muscle cramps in any patient group (i.e. all clinical presentations of cramp) and to considere comparisons of magnesium with no treatment, placebo control, or other therapy, found that it is unlikely that magnesium supplementation provides clinically meaningful cramp prophylaxis to older adults experiencing skeletal muscle cramps. In contrast, for those experiencing pregnancy-associated rest cramps the literature is conflicting and further research in this patient population is needed. We found no randomized controlled trials evaluating magnesium for exercise-associated muscle cramps or disease state-associated muscle cramps (for example amyotrophic lateral sclerosis/motor neuron disease)(1).
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22972143

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Pyridoxine (vitamin B6) Neurotoxicity

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Although vitamin B6 has expressed various health benefits such as induced a healthy metabolism, improved nerve, liver function and enhanced skin health, eye health, over dose of vitamin B6 may cause toxicity in induction of peripheral neuropathy, despite renal excretion of this water-soluble vitamin.

According to the Nathan S. Kline Institute for Psychiatric Research, in the experiment of anephric rats show that the uremic state, in a mere 3 or 4 days, causes a 5- to 10-fold increase in susceptibility to pyridoxine-induced neuronopathy.

Uremia is a serious medical complication of patients with chronic kidney disease and acute kidney injury.

Therefore, there is a need for caution in prescribing pyridoxine to uremic patients who will probably take the vitamin daily for many years. Large amount intake may only prescribe by medical profession.

Further analysis in the toxicity of over dose vitamin B6, researchers at the above university also conducted a experiment of its toxic effect in ther brain found that dietary protein deficiency may be a culprit in elevation of neurotoxicity of pyridoxine.

In a mere 3 or 7 days of pretreatment with either of two protein-deficient diets were sufficient to accelerate and intensify the clinical neurological signs even in the injection of normal dose of vitamin B6.

Additional examination suggested that the elevated levels of vitamin B6 may be casued by at least in part, by loss of body weight, decreased protein binding in serum and decreased consumption of water and decreased volume of urine, which reduce the urinary losses of the toxicant.

In compared to the levels of toxicity of different types of vitamin B6 derivative, pyridoxine (pyridoxal, pyridoxamine) and the coenzyme (pyridoxal 5-phosphate) did not cause clinical signs or lesions similar to those produced by pyridoxine even when injected in maximum tolerated doses.

More interestingly, in an examined the sequence of nervous system abnormalities that resulted when rats given excess amounts of vitamin B6 (pyridoxine of 1,200 or 600 mg/kg/d) for 6 to 10 days researchers suggested that high dose of vitamin B6 are sensitively affect the large diameter neurons with long processes and large cytoplasmic volumes in compared to application of smaller doses (300 to 150 mg/kg/d) for up to 12 weeks with lesser effects on DRG neurons, but produced a neuropathy with axonal nerve fiber atrophy and degeneration

Dorsal root ganglion (DRG) neurons is a cluster of nerve cell bodies in a dorsal root of a spinal nerve, containing the cell bodies of sensory neurons.

The effect of vitamin B6 are also depending types of animal model used in the experiment as guinea pigs given 1,800 mg/kg/d developed sensory neuronopathy, whereas mice given similar or higher doses did not have neuropathologic abnormalities.

Therefore, multiple factors must be taken into consideration, such as rate of administration, differential neuronal vulnerability, and species susceptibility before one can make the final expression of pyridoxine neurotoxicity.

Taking altogether, vitamin B6 may have many health benefits but intake of large dose as vitamin supplement can only be prescibed by medical professional to prevent neurotoxicity.

 

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Sources
(1) Pyridoxine (vitamin B6) toxicity: enhancement by uremia in rats by Levine S1, Saltzman A.(PubMed)
(2) Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein-deficient diet by Levine S1, Saltzman A.(PubMed)
(3) Dose-dependent expression of neuronopathy after experimental pyridoxine intoxication by Xu Y1, Sladky JT, Brown MJ.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Antiepileptic Drugs in Vitamin B6 Metabolism

By Kyle J. Norton.

Antiepileptic drugs are class of anticonvulsants used in the treatment of epileptic seizures.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Although vitamin B6 and its derivative have shown a strong impact in treatment of all groups of epilepsy, intake of antiepileptic drugs do not influence to the expression of plasma levels of vitamin B6, according to the University Hospital Zurich, in the study of analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233).

But further differentiation of the interaction of vitamin B6 in patient with epilepsy underdone treatment of antiepileptic drugs (AEDs) including phenytoin or carbamazepine) and non-inducing AED (levetiracetam, lamotrigine, or topiramate), researcher found that
1. Contrast to general belief that intake of antiepileptic drugs did not lower either levels of folate nor vitamin B12, observed by blood test.
2. Vitamin B6 deficiency was found in 16/33 patients (48%) in compared to 1/11 controls (9%; p=0.031)

3. Patients in antiepileptic drugs group showed a significant in vitamin B6 deficiency of only 7 patients (21%) .after switching to non inducers.

After taking into account of con founders, Dr. Mintzer S, the lead author said, "The incidence of deficiency was similar regardless of which inducing or non-inducing AED was being taken" and "treatment with inducing AEDs commonly causes pyridoxine deficiency, often severe".

Intrusively, the study also address that other health conditions in patients with epilepsy also must be taken into consideration before injection of older AED as the medicine may induced neuro damage and chronic heath difficulties.

More importantly, in the study to determine the means of determination of activity of EGOT in 30 and of serum pyridoxal phosphate in 27 epileptic children under antiepileptic treatment with various antiepileptic drugs and with hydantoin and succinimide alone, 25 healthy infants and children were controls, researchers indicated that
1. Application of antiepileptic drugs, especially with hydantoin and succinimide depressed the level of pyridoxal-phosphate in serum
2. Injection of various antiepileptic drugs may disturb the vitamin B6 metabolism through inhibition of activity of pyridoxalkinase.

Therefore, vitamin B6 testing in patients treated with hydantoin and succinimide may be necessary to prevent risk of reduced vitamin b6 metabolism cause of toxic effects in several neurological pathologies.

Taking altogether, injection of antiepileptic drugs  may have a complicative effect in reduced vitamin B6 metabolism in induction of neuro damage and chronic heath difficulties.

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Sources
(1) Antiepileptic drugs and vitamin B6 plasma levels in adult patients by Linnebank M1, Moskau S, Semmler A, Widman G, Weller M, Kallweit U, Elger CE.(PubMed)
(2) B-vitamin deficiency in patients treated with antiepileptic drugs by Mintzer S1, Skidmore CT, Sperling MR.(PubMed)
(3) The influence of antiepileptic drugs on vitamin B6 metabolism by Reinken L.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 and Treatment of Pyridoxine-Dependent Epilepsy

By Kyle J. Norton.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions in stimulation of carbohydrate metabolism, brain health, and liver detoxification, etc.

The effect of vitamin B6 in treatment of pyridoxine-dependent epilepsy was under microscopic investigations extensively through many aspects, particularly in vitamin B6 application.

In inborn errors of autosomal recessive inheritance that lead to vitamin B6-dependent seizures, after taking account of other con founders, researchers suggested that a vitamin B6 withdrawal for diagnose should also be considered as an therapy for resistant neonatal seizures as early consideration of a vitamin B6 trial over 3 consecutive days is crucial in order to prevent irreversible brain damage, instead of only for patients with a clear vitamin B6 response.

Neonatal seizures, a medical condition of occurrence of seizures due to neurologic dysfunction in the neonatal period.

Pyridoxine, an the active form of vitamin B6 would be effective commonly in treatment of vitamin B6-dependent seizures, but pyridoxine showed no signs of potency in patients with neonatal seizures due to PNPO deficiency.

Pyridoxal 5'-phosphate-dependent epilepsy(PNPO) is a condition with failure response to vitamin B6 treatment in seizures patients.

The use of PLP in patients with resistant neonatal seizures should be taken with care with resuscitation equipment at hand during a first pyridoxine/PLP administration, as severe apnea has been occurred in patients, researcher continued.

Unfortunately, due to PLP is unlicensed within Europe and North America, pyridoxine is widely used as the first line drug, therefore for patient do not response to the treatment of PLP, some researchers suggested that PLP injection may be necessary and should be followed by a trial, especially in neonates.

Furthermore, caregivers, including parents with children with epilepsy should be inform about the lifelong dependency and recurrence risks in forthcoming pregnancies.

Further analysis of  the resistant conventional antiepileptic medications of early-onset epilepsy in children with neonates caused by hypophosphatasia and congenital rickets and in compared to patients of hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency of epilepsy, also indicated that although many patients with epilepsy are response to treatment of vitamin B6 injection but PLP treatment was more effective than pyridoxine, through some unknown mechanisms.

Dr. Wang HS, the lead author said, "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Additionally, Pyridoxine-dependent epilepsy (PDE) may also be caused by genetic mutation of certain genes, such as c.1597_1597delG mutations in ALDH7A1 gene.

Observation of patients data in 3 groups with complete seizure control with pyridoxine and normal development (group 1), complete seizure control with pyridoxine and development delay (group 2), and patients with persistent seizures despite pyridoxine treatment and with development delay (group 3) researchers at the Çukurova University Faculty of Medicine found that early diagnosis and treatment of these patients is vital. Patients with persistent seizure despite pyridoxine treatment and with development delay should be diagnosed in condition of any neonate with signs of encephalopathy and refractory seizures.

Taken together, if patients with epilepsy do not response to treatment of application of vitamin B6, PLP injection may be considered but substantial care must be taken  to reduce risk of complications of severe apnea.
 

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Sources
(1) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(2) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(3) Pyridoxine-dependent epilepsy in two Turkish patients in Turkey and review of the literature by Gül-Mert G1, İncecik F, Hergüner MÖ, Ceylaner S, Altunbaşak Ş.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 in Reduced Risk and Treatment of non-small cell lung cancer (NSCLC)

By Kyle J. Norton.

Vitamin B6 may have a profound effect in reduced non-small cell lung cancer (NSCLC), some scietists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Non-small cell lung cancer is the most common type of lung cancer with characteristic to grow and spread methodically and predictably.

In the study to examine the clinical outcomes of the sodium cantharidinate/vitamin B6/GP regimen in the treatment of middle-late stage Non-small-cell lung carcinoma (NSCLC) with
86 cases of NSCLC selected and randomized into two groups; 45 cases in the treatment group were given 30 ml cantharidinate/vitamin B6+ GP regimen, for four 21-day cycles and 41 cases in the control group were subject to regular GP regimen, for four 21-day cycles, at the end of experiment, researchers found
1. Treatment group showed a significant improvement with effectiveness rate of 57.8% in compared to 36.6% in the control group,
2. Patients in group demonstrated an improvement of quality of life
3. Treatment group also displayed a lower toxic/adverse effects in compared with that in the control group.

After taking into account of other risk factors, Dr. Wang B, the lead author said, "odium cantharidinate/vitamin B6/GP regimen had fair effectiveness and synergistically improved the clinical outcomes. It lowered the toxic/adverse effects and its application is worth further investigation and promotion".

Other, in the study to examine the effect vitamin B6 for treatment of non-small cell lung cancer, after observation of vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo, researchers at the INSERM showed that
1. Vitamin B6 sensitized lung cancer cells to apoptosis induction by distinct types of physical and chemical stress.
2. Pyridoxal kinase (PDXK), the enzyme played an important role in generated the bioactive form of vitamin B6 and deficiency of PDXK expression levels were associated with poor disease outcome in two independent cohorts of patients with NSCLC.

The result of the study demonstrated the important role of pyridoxal kinase (PDXK) in exhibited vitamin B6 in reduced risk and treatment of NSCLC.

In fact, most patients with NSCLC are found to correlation with low levels of pyridoxal kinase (PDXK).

Taking altogether, vitamin B6 may be considered as a secondary and therapeutic treatment of NSCLC.

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Sources
(1) Treatment of mid-late stage NSCLC using sodium cantharidinate/vitamin B6/GP regimen in clinic by Wang B, Cui J1.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 in Reduced Risk of Depression

By Kyle J. Norton.

Vitamin B6 may have a intrinsic effect in reduced symptoms of depression, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

In the study to investigate whether different intake levels of folate, vitamin B6 and B12 were associated with a 3-year depression incidence among generally healthy, community-dwelling older men and women conducted by the joint study lead by the St Francis Xavier University, researchers showed that
1. Vitamin B6 intake from foods were associated to 43% less likely to become depressed when adjusting for demographic and health factors in women.
2. Risk of depression also decreased in men who took dietary vitamin B6 during the study.


The results indicated that dietary vitamin B6 may be the choice for both men and women to reduced risk of depression.

Other in the study to investigate whether adolescent pregnant women were on greater risk of nutritional deficits in stress, and depression than their adult counterparts, and these risk factors associated to adverse pregnancy outcomes, researchers at the joint study lead by the Columbia University Medical Center, suggested that vitamin B6 was one of many micro nutrients found in deficient status in these group of women.

After taking into account of other risk factors, Dr. Singh A, the lead author postulated, "mood and dietary factors are associated and should be considered together for health interventions during adolescent pregnancy for the young woman and her future child".

Taking altogether, vitamin B6 may be considered as an adjunct supplement with standard therapy for reducing risk of depression in general population.

 
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Sources
(1) Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging by Gougeon L1,2, Payette H3,4, Morais JA5, Gaudreau P6,7, Shatenstein B8,9, Gray-Donald K2.(PubMed)
(2) Micronutrient Dietary Intake in Latina Pregnant Adolescents and Its Association with Level of Depression, Stress, and Social Support by Singh A1,2,3, Trumpff C4, Genkinger J5,6, Davis A7, Spann M8,9, Werner E10,11, Monk C12,13,14.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 in Reduced Psychological symptoms of Schizophrenia

By Kyle J. Norton.

Vitamin B6 may have a potential effect in reduced psychological symptoms in chronic schizophrenic and schizoaffective patients, some researchers suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Schizophrenia is a severe mental disorder characterized with inability to interpret reality normally and Schizoaffective disorder is also a chronic mental health condition characterized primarily by symptoms of schizophrenia.

In a study to examine the effects of vitamin B6 reduced psychotic symptoms of psychopharmacologic treatment of patients suffering from schizophrenia or organic mental disorder, of spanning 9 weeks with all patients with stable psychopathology for at least 1 month before entry and randomly received placebo or vitamin B6, starting at 100 mg/day in the first week and increasing to 400 mg/day in the fourth week by 100-mg increments each week, researchers found that there are no differences between vitamin B6- and placebo-treated patients in amelioration of mental state of attendees.

Dr. Lerner V, after taking into account of other confounders, said, "Further studies with larger populations and shorter duration of illness are needed to clarify the question of the possible efficacy of vitamin B6 in treatment of psychotic symptoms in schizophrenia".

Other researchers in the confirmation of vitamin B6 great progress in the treatment of positive symptoms in schizophrenic patients and movement disorders induced by neuroleptics,at the Ben Gurion University of the Negev, launched a a double-blind crossover controlled during 9 weeks with patient treated with up to 400 mg/day vitamin B6 versus placebo, after reviewing the result taken from Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Symptoms Rating Scale (ESRS) and a blood sample of level pyridoxal showed that vitamin B6 treated group demostrated a significant improvement in tardive dyskinesia and parkinsonian symptoms. but failed to express therapeutic effect of psychotic symptoms from vitamin B6 added to antipsychotic agents.

The contradictory findings suggested that further studies with larger samples and higher doses of vitamin B6 are necessary before clarifying the possibility of a positive therapeutic effect of vitamin B6 as an augmentation agent for the treatment of psychotic symptoms.

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Sources
(1) Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study by Lerner V1, Miodownik C, Kaptsan A, Cohen H, Loewenthal U, Kotler M.(PubMed)
(2) [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders].[Article in Hebrew] by Miodownik C1, Cohen H, Kotler M, Lerner V.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 for Treatment of Anxiety

By Kyle J. Norton.

Vitamin B6 may have an positive effect in reduced levels of anxiety, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Anxiety, a psychological symptom caused by a feeling of worry, nervousness, or unease, particularly about an imminent event or something with an uncertain outcome.

According a randomized, double-blind, placebo-controlled and crossover design study to investigate single and combined effects of daily dietary supplementation with 50 mg of vitamin B6 and 200 mg magnesium (as MgO) for one cycle for the relief of mild premenstrual symptoms, among 44 assigned to treatments daily for one menstrual cycle: (1) 200 mg Mg, (2) 50 mg vitamin B6, (3) 200 mg Mg + 50 mg vitamin B6 and (4) placebo, after taking into account of other risk factors, researchers showed that treatment with 200 mg/day Mg + 50 mg/day vitamin B6 expressed a significant reduction of anxiety-related premenstrual symptoms (nervous tension, mood swings, irritability, or anxiety) in compared to other treated groups, specially in mild premenstrual anxiety-related symptoms.

Other in the study to evaluate the effect of combination of Magne-B6 used, in the treatment of 25 patients with different forms of epilepsy with psychiatric status of patients featured by depression, anxiety and some psychotic sighs researchers indicated that according to the results of self-rating scales for Zung anxiety and depression scale, SCL-90 and Global clinical impression (CGI) scale, the combination display a strong effect in non-specific influence on patient's mental state at between the 14 - 28 days of treatment without inducing serious side effects.

Taking altogethers, Vitamin B6 may be used alone or conjunction with other minerals supplement for treatment of anxiety.
 

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Sources
(1) A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study by De Souza MC1, Walker AF, Robinson PA, Bolland K.(PubMed)
(2) [A use of Magne-B6 in the treatment of anxiety-depressive states in patients with epilepsy].[Article in Russian] by Kalinin VV, Zheleznova EV, Rogacheva TA, Sokolova LV, Polianskiĭ DA, Zemlianaia AA, Nazmetdinova DM.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All Above Vitamins: The Effect of Vitamin B6 on Central Nervous System

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Central nervous system is a part of nervous system, including the brain and spinal cord.

Vitamin B6 may have a profound and positive effect in reduced neuro toxicity used conjunction with other herbal medicine, some scientists suggested

In a study to investigate the neuroprotective role of grape seed extract and/or vitamin B6 against Triton WR-1339 -induced neurotoxicity, with 35 adult male albino rats of the Sprague-Dawley strain, weighing 140-145 g, divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + tritonresearchers at the Alexandria University found that application of grape seed extract and/or vitamin B6 demonstrated a significant effect in attentuated disturbances in the hematological parameters, the neurological functions, and the antioxidant profile, caused py injection of the above product.

Further analysis suggested that grape seed extract and/or vitamin B6 protect against neuro damage caused by Triton WR-1339 through over expression of antioxidative and antiapoptotic capacities.

In support to the above study, researchers at the Laboratori di Ricerca della FIDIA S.p.A, launched a study to examine the effect of a brain cortex phospholipids (BC-PL) and vit. B6 association on animal behaviour and enzymatic activities specific for CNS postulated that although vitamin B6 showed a strong positive influence to BC-PL and  activities, the results obtained are very different in compared to  methamphetamine used for treatment of CNS.

The result suggests a different mechanism of action at CNS level, according to the motility and avoidance tests and cerebral L-amino acid aromatic decarboxylase assays.

Taking together, there is no doubt that vitmain B6 has a intrigue effect in improved and protective central nervous system activities.

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Sources
(1) Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity by Abdou HM1, Wahby MM2.(PubMed)
(2) [Neurochemical and behavioural alterations in animals due to a neurohomologous phospholipids and vitamin B6 association at CNS level].[Article in Italian] by Aporti F1, Toffano G, Castellani A.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 Deficiency and Risk of Type 2 Diabetes

By Kyle J. Norton.


Vitamin B6 may have a positive and profound impact in reduced risk of type 2 diabetes in patients with depression and other conditions, some studies suggested

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

Diabetes is a medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

According to Dr. Oxenkrug G, the lead author in the investigate the effects of vitamin B6 deficiency in risk of type 2 diabetes, as a cofactor of the key enzymes in regulating trytrophan metabolism, suggested that vitamin B6 deficiency may alter the formation of co enzyme (NAD) towards production of xanthurenic (XA) and kynurenic (KYNA) acids, which have a strong impact in the production, release and biological activity of insulin.

Where Xanthurenic acid is excreted by pyridoxine (vitamin B6) deficient and Kynurenic acid is a product of the normal metabolism of amino acid L-tryptophan.

The study also indicated that increased intake of vitamin B6 supplement and monitored formation of diabetogenic KYN derivatives might help to identify subjects-at-risk for the development of diabetes.

Further analysis, the authors also said, "Pharmacological down-regulation of the TRP - KYN - NAD pathway and maintenance of adequate vitamin B6 status might help to prevent the development of diabetes in depression and other conditions associated with inflammation/stress- induced excessive production of KYN and vitamin B6 deficiency, e.g., o".

In support to the above differentiation, the Tufts University School of Medicine conducted a study to review literature published data for evidences that dysregulation of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) metabolic pathways is one of the mechanisms of IR suggested that vitamin B6 deficiency may impair the function of key enzymes of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) in production, release, and biological activity of insulin, thus increasing risk of type 2 development.

Taking together, thee is no doubt that vitamin B6 deficiency may have a significant effect in the onset of type 2 diabetes by alternating the production, release, and biological activity of insulin, through trytophan metabolic pathway.

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Sources
(1) Kynurenines and vitamin B6: link between diabetes and depression by Oxenkrug G, Ratner R, Summergrad P.(PubMed)
(2) Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways by Oxenkrug G1.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 deficiency in Risk of Hyperhomocysteinaemia

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong implication on  hyperhomocysteinaemia in increased risk of cardiovascular disease, some studies suggested

Homocysteinaemia, a maker for heart disease development, is a medical condition characterized by an abnormally level of homocysteine in the blood stream.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

According to the study conducted by the The Aga Khan University, to evaluate the homocysteine levels of 290 apparently healthy hospital personnel from institutions in two cities of Pakistan, deficiency of vitamin B6 and other vitamins may be associated to higher risk of  homocysteine in compared to control.

Indeed, Dr. Iqbal MP, the lead author indicated that serum/plasma levels of micro nutrients have a significant negatively correlated with plasma homocysteine.

In other word, Deficiency of certain micro nutrients, including vitamin B6 may increase substantial risk to hyperhomocysteinaemia.

The result strongly support that mass micro nutrient supplementation are necessary in this group of people to prevent the high incidence of cardiovascular disease.

Other study in the instigation of the same group of Pakistani people, involving 224 AMI patients (age 30-70 years; 55 females and 169 males) and 126 normal healthy subjects (age 31-70 years; 35 females and 91 males) for risk of hyperhomocysteinaemia in micro nutrients deficiency aspects, researchers showed that a lower levels of vitamin B6 and other micro nutrients, including folate and vitamin B6 demonstrated a significant effect in the onset of hyperhomocysteinaemia in both control and study group.

Dr. Iqbal MP, the lead author said, "Substantial nutritional deficiencies of these three vitamins along with mild hyperhomocysteinemia, perhaps through an interplay with the classical cardiovascular risk factors". 

Taking altogether, vitamin B6 may have a profound effect in combined with deficiencies of other nutrients in induced risk of hyperhomocysteinaemia development, a marker of CVD.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Folic acid and vitamin B6 deficiencies related hyperhomocysteinemia in apparently healthy Pakistani adults; is mass micronutrient supplementation indicated in this population? by Iqbal MP1, Lindblad BS, Mehboobali N, Yusuf FA, Khan AH, Iqbal SP.(PubMed)
(2) Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction by Iqbal MP1, Ishaq M, Kazmi KA, Yousuf FA, Mehboobali N, Ali SA, Khan AH, Waqar MA.(PubMed)

All About Vitamins: Vitamin B6 In reduced Risk of hypertriglyceridemia

By Kyle J. Norton.

Vitamin B6 may have a positive and profound effect in reduced risk of hypertriglyceridemia some studies suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study to investigate the effect of lysine, vitamin B(6), and carnitine supplementation on both glycemia and the lipid profiles, specifically triglyceride (TG) levels of a total of 85 hypertriglyceridemic (TG> 150 mg/dL) male patients randomizedly assigned to 1 of 5 groups given supplements of lysine (1 g/d), vitamin B(6) (50 mg/d), lysine (1 g/d) + vitamin B(6) (50 mg/d), carnitine (1 g/d), or placebo for 12 weeks, after taking into account of other con founders, researchers filed the following report
1. VitaminB(6) supplementation given in an equated amount was associated with a significant reduction in total cholesterol and HDL-C of 10%.
2. Plasma total cholesterol TG was reduced by 36.6 mg/dL at 6 weeks
3. Administration of lysine and carnitine groups showed no change in lipid file

Interestingly, although chemical compound lysine and carnitine play an important role in alternating fat metabolism to induce hypertriglyceridemia, they have no impact in expression of total cholesterol and HDL-C concentrations

Further analysis, Dr. Hlais S the dead author said, "Vitamin B(6) supplementation in these male patients with hypertriglyceridemia reduced plasma total cholesterol and HDL-C concentrations". 

Other in the study to investigate the effect of elevated plasma concentrations of homocysteine, a sulfur-containing amino acid, are a risk factor for coronary, cerebral and peripheral artery disease caused by vitamin B6 and other micro nutrients deficiency suggested that the use of addition of folic acid, vitamin B12 and B6 to fibrates reduced intake of two important classes of drugs, lipid-lowering drugs and anti-hypertensive drugs, on homocysteine metabolism for prevention of CVD.

Dr. said, "(drugs) used for treatment of hypertriglyceridemia and low HDL-cholesterol, are associated with an increase of homocysteine by 20%-50%".

Taking altogether, vitamin B6 have a significant effect in reduced risk of CVD through lowering the levels of bad cholesterol and total cholesterol and reduced production of  homocysteine drugs used for treatment hypertriglyceridemia.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial by Hlais S1, Reslan DR, Sarieddine HK, Nasreddine L, Taan G, Azar S, Obeid OA.(PubMed)
(2) Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels by Dierkes J1, Luley C, Westphal S.(PubMed)

All About Vitamins: Vitamin B6 In decreased Symptoms Severity In Premenstrual Syndrome

By Kyle J. Norton.

Vitamin B6 may have a strong impact in reduced symptoms in women with premenstrual syndrome, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts, effecting over 70% to 90% of women in the US.

In the study of 84 female students lived at the university dorm, randomly selected and allocated into two groups of 42 with the first group received auriculotherapy (10 sessions) for two menstrual cycles and the second group consumed 40 mg of vitamin B6 daily from a week before their menstruation for two menstrual cycles, after examining the returned questionnaire, researchers filed the following results
1. Both groups showed a significant difference compared to before the intervention
2. Vitamin B6 treated group displayed a mean score of 22.60 (10.87) and 24.17 (14.15), in the first and second cycles in compared to the auriculotherapy group of 26.70 (19.49) and 24.76 (17.07)
3. After considering other risk factors, in comparing the total score of symptoms in the first and second cycles after the intervention, both groups showed no significant difference.

In other word, both vitamin B6 and  auriculotherapic treatment expressed an decreased symptoms of  premenstrual syndrome.

Additionally, in a two-stage double-blind clinical trial conducted on 126 women and randomly allocated into 3 groups to receive magnesium, vitamin B6, or placebo performed in 10 selected health centers in Isfahan and lasted for 4 months, researchers reported that all groups showed a significantly decreased the mean scores of premenstrual syndrome after the intervention.

However, in compared to magnesium treatment group, vitamin B6 and placebo had the most and least efficiency in improving the mean premenstrual syndrome score.

Interestingly, in a double blind randomized controlled carried out on 76 students of Hamadan University of Medical Sciences and randomly allocated to two groups, 38 people in each group either received calcium tablet (500mg) and vitamin B6 (40 mg) or only vitamin B6 twice a day for two consecutive months, researchers indicated that although vitamin B6 alone treatment group expressed some improvement of symptoms pf PMS, but combination of calcium and vitamin B6 are far more better in controlling of the premenstrual syndrome symptoms.

Taking altogether, There is no doubt that vitamin B6 may be recommended as a potential and therapeutic supplement in reduced the severity of symptoms of PMS.

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Sources
(1) Comparing the Effect of Auriculotherapy and Vitamin B6 on the Symptoms of Premenstrual Syndrome among the Students who Lived in the Dorm of Isfahan University of Medical Sciences by Koleini S1, Valiani M2.(PubMed)
(2) Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms by Ebrahimi E1, Khayati Motlagh S1, Nemati S1, Tavakoli Z1(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 in Improved Infant childhood Neuromotor Activities

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong impact in behavioral effects in child neuro development, a renowned study suggested.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In animal study to investigate behavioral effects of preweaning pyridoxine deficiency, researchers filed the following results
1. Rat with vitamin B6 deficiency expressed less the body weight in compared to control
2. The vitamin B6 deficiency rat also displayed a delay of supported standing and eye opening
3. Reduced open-field activity reflected by the exploratory score was also observed in vitamin-deficient rats

Dr. Krishna AP, after taking account of other co founders said, "considerable effects of prenatal pyridoxine deficiency were observed in the neonatal pups as stunting of growth and in the delayed onset of neuromotor coordination as well as a low level of open-field activity".

These results reflected the important role of of maternal pyridoxine supplementation during pregnancy in reduced risk of child neuro development abnormality, particularly in neuromotor coordinations.

Other, in the support of the above analysis, researchers at the A.B. Shetty Memorial Institute of Dental Sciences, conducted a review of the effect of preweaning pyridoxine deficiency in induced lower the body weight and brain weight in compared to control found that
1. Vitamin B6 deficiency rat showed a delay of stabilisation of reflex reactions
2. Reaction of these group of rat expressed in maturation of neuromotor coordination also significantly slow

Dr. Krishna AP, the led author said, "This suggests that the importance of maternal pyridoxine supplementation cannot be overlooked in pregnant women especially after prolonged use of anovulatory steroids".

Taking altogether, Oral administrated of vitamin B6 may have a profound effect in reduced risk of 

childhood neuromotor abnormality if taken with recommended dose during pregnancy, particularly in women with prolonged use of anovulatory steroids'.

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Sources
(1) Effect of pyridoxine deficiency on the exploratory behavior of rats by Krishna AP, Ramakrishna T.(PubMed)
(2) Effect of pyridoxine deficiency on maturation of neuromotor coordinations by Krishna AP1, Ramakrishna T.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins" Vitamin B6 in Improved Cognitive Function?

By Kyle J. Norton.

Vitamin B6 may have a therapeutic effect in improved cognitive development of offsring, a Johns Hopkins University School of Hygiene and Public Health study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study the effect of vitamin B6 in pregnant and lactating women,  researchers found that recommended dietary allowance of vitamin B6 may have a strong effect in improved cognitive and brain development as the nutrient is an essential cofactor in the developing central nervous system of fetus.

Dr. Guilarte TR, at the study said, " Recent work in animal models suggests that vitamin B6 deficiency during gestation and lactation alters the function of N-methyl-D-aspartate receptors, a subtype of receptors of the glutamatergic neurotransmitter system thought to play an important role in learning and memory".

Other, in the study of nutrient effect on cognitive impairment, patients with AD expressed a 50% deficits of various nutrients, including folic acid, vitamin B12, B6, C, E, A, D, K, beta carotene and omega 3 fatty acids.

Interestingly, In the investigation of whether baseline folate, vitamin B-6, and/or vitamin B-12 intake, alone or in combination, are associated with incident MCI/probable dementia among older women containing 7030 Postmenopausal women free of MCI/probable dementia at baseline in the Women's Health Initiative Memory Study, after carefully examine the returned questionnaire, researchers indicated that vitamin B6 showed no effect in improved symptoms of dementia in this group of women.

Taking together, vitamin B6 may have a profound effect in reduced risk of brain and cognitive abnormality in infant if taken according to recommended doses during pregnant. However, the vitamin does not reduce symptoms in patient with dementia.

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Sources
(1) Vitamin B6 and cognitive development: recent research findings from human and animal studies by Guilarte TR1(PubMed)
(2) Nutrition and cognitive impairment by [Article in Spanish; Abstract available in Spanish from the publisher] by Hernando-Requejo V1.(PubMed)
(3) Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study by Agnew-Blais JC, Wassertheil-Smoller S, Kang JH, Hogan PE, Coker LH, Snetselaar LG, Smoller JW.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 for Treatment of Symptoms of Carpal Tunnel Syndrome?

By Kyle J. Norton.

Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, an Iran study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Carpal Tunnel Syndrome is a condition, characterized by numbness, tingling, weakness, or muscle damage in the hand and fingers, as a result of the pressure on the median nerve.

In the study of Forty patients (67 hands) with mild-moderate CTS initially selected and randomly assigned into two groups as follows: 1) Case group with 20 subjects (32 affected hands) receiving vitamin B6 (120 mg/day for 3 months) and splinting. 2) Control group with 19 subjects (35 affected hands) only received splinting, researchers filed the following reports

1. Vitamin B6 treatment group expressed a strong improvement of nocturnal awakening frequency due to pain, daily pain, daily pain frequency, daily pain persistence, hand numbness, hand weakness, hand tingling, severity of nocturnal numbness and tingling, nocturnal awakening frequency owing to hand numbness and tingling, and clumsiness in handling objects. in compared to other groups

2. However, oral administrated vitamin B6 group displayed insignificant result in opening a jam bottle and handling phone in compared to control
3. Vitamin B6 groups also demonstrated an improvement of median nerve sensory latency mean decreased and the median nerve sensory amplitude mean and sensory conduction velocity mean increased.

Dr. Talebi M, the led author said, "vitamin B6 treatment improves clinical symptoms and sensory electrodiagnostic results in CTS patients" and "(it) is recommended for CTS treatment".

Other, in the study of a 42-year-old woman with carpal tunnel syndrome started taking vitamin B6 supplement to relieve her symptoms, researchers indicated that vitamin B6 is often used as a conservative and adjunct therapy for patients with carpal tunnel syndrome, but patients attempted to treat their symptoms with vitamin B6 on their own should be aware that Vitamin B6 at more than 200 mg daily may induce some unpredictable adverse effects.

Dr. Ryan-Harshman M, the led authorsaid, " Vitamin B6 at less than 200 mg daily is not likely to cause any adverse effects, but patients should be monitored for changes in symptoms, particularly when high doses are taken over long periods".

Contrastively, in the Electroencephalogram (EEG) studies to evaluate the role of vitamin B6 as a therapeutic agent in the treatment of carpal tunnel syndrome by monitoring both the standard clinical and electrophysiological parameters for entrapment neuropathy at the wrist, researchers disagreed that vitamin B6 may be sued for treatment of carpal tunnel syndrome, as patients in the tested showed no changes occurred during the treatment period. Motor latency, while the most common screening test for carpal tunnel syndrome, was not significantly changed during the course of treatment.

Taking altogether, Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, but large sample size and cohost studies are necessary to prove this validity.

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Sources
(1) Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome by Talebi M1, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A.(PubMed)
(2) Carpal tunnel syndrome and vitamin B6 by Ryan-Harshman M1, Aldoori W.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B6 for Treatment of inborn errors Epilepsy

By Kyle J. Norton.

Vitamin B6  supplement may have a profound effect in reduced risk of childhood epilepsy, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In concern of inborn errors of metabolism in affecting vitamin B6 concentrations in the brain in induced early-onset epilepsy, without showing hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency researchers at the Chang Gung University found that pyridoxal phosphate (PLP), the active form of vitamin B6 displayed a significant effect in treating patients without the above four disorders.

The study also indicated that patients with pyridoxine phosphate oxidase deficiency also responded to pyridoxal phosphate (PLP) instead of pyridoxine.

DR. Wang HS, the led author said, "patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known" and "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Others, in the support of the about differentiation also postulated that PLP therapy also found to be effective in treatment of all four disorders, but pyridoxine oral intake failed to improved seizures in PNPO deficiency.

However, PLP treatment in epilepsy expressed some adverse effect in severe apnea, therefore  resuscitation equipment should be at hand during a first pyridoxine/PLP administration. 

Interestingly, in he study of four genetic epilepsies with vitamin B6 dependent seizures, particularly, to pyridoxine therapy resistant seizures in the neonatal period with PNPO patients researchers found these patients may need PLP substitution and therapy resistant seizures diagnosed early can prevent irreversible neurologic damage.

Taking altogether, there is no doubt that vitamin B6 in form of pyridoxine and PLP may have a therapeutic effect in treatment childhood epilepsy. But in case of therapy of resistant seizures, substitution of pyridoxine by PLP are always necessary.

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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Sources
(1) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(2) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(3) Vitamin B6 dependent seizures by Plecko B1, Stöckler S.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.