Ginger, The Best for the Treatment of Diabetes and Diabetes Complications With No Side Effect

Ginger may have a potential and profound effect in regulating the abnormally high blood sugar, some scientists suggested.

Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

According to the statistic, approximately, 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes. And, hyperglycemia is a hallmark sign of diabetes(both type 1 diabetes and type 2 diabetes) and prediabetes.

Some researchers suggested that people who are living under prolonged periods of stress due to chronic illness or stress are associated with a higher risk of high blood sugar.

Other suggested that an unhealthy diet such as high in saturated and trans fat, red meat, and processed food and lack of physical exercise have many folds increased the risk for the onset of hyperglycemia.

In fact, shift workers accompanied by an unhealthy lifestyle are the joint association with the risk of type 2 diabetes.

Dr. Shan Z, in the concerns of the rotating night shift work and lifestyle factors in the risk of diabetes using the data of Nurses' Health Study (1988-2012) and Nurses' Health Study II (1991-2013) and comparing to the 143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline, said, " The multivariable-adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five year increment of duration of rotating night shift work and 2.30 per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity)".

"For the joint association of per five-year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001)".


How severe the diabetes risk in nurses in the rotating shift accompanied by an unhealthy diet. According to the team, during 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred.

The risk of type 2 diabetes is even higher if each individual factors are also included.


These results clearly suggested, the onset of diabetes is not caused by a single factor but associated with a group set of risk factors.


Luckily, most people with some of above risk factors do not develop hyperglycemia or type 2 diabetes.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient and whole food for the treatment of diabetes and diabetes complications, researchers examine the action of ginger in the diabetic population.

Selected mice fed by either high fat diet or standard diet for a period of 17weeks were given phloretin isolated from apple and [6]-gingerol isolated from ginger supplemented at two different doses.

Application of phloretin and [6]-gingerol inhibited the formation of AGEs by suppressing the receptor for advanced glycation end products (RAGE).

Where Advanced glycation end products are proteins or lipids that become glycated as a result of exposure to sugars. The products can substantially worsen certain chronic diseases such as diabetes.


Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs, and insulin levels and enhanced GSH/GSSG ratio.

These results suggested that phloretin or [6]-gingerol supplementation not only inhibited the oxidative stress that causes abnormally high blood glucose but also improved the insulin resistance against the onset of diabetes complications in mice fed with high-fat diet.

Futhermore, the assessment of the effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus with the consumption of 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks, also found that ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with placebo group (p < 0.05).

Ginger improved fasting glucose and parameters associated with the onset of insulin resistance without inducing any side effects.

Dr. Arablou T after taking into account co and confounders said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered an effective treatment for the prevention of diabetes complications".

Taken altogether, ginger may be considered a functional food for the prevention and treatment of diabetes and diabetes complication induced by abnormally high blood glucose.




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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M. (PubMed)
(2) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(3) Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats by Tzeng TF1, Liou SS2, Tzeng YC3, Liu IM. (PubMed).
(4) Rotating night shift work and adherence to an unhealthy lifestyle in predicting the risk of type 2 diabetes: results from two large US cohorts of female nurses by Shan Z1,2, Li Y2, Zong G2, Guo Y3,4, Li J2,3, Manson JE3,5, Hu FB2,3,6, Willett WC2,3,6, Schernhammer ES3,6,7, Bhupathiraju SN2, (PubMed)