Herbal Aloe Vera, the Natural Remedy for the Treatment Psoriasis

Herbal Aloe vera may be a potential therapeutic remedy for the prevention and treatment of psoriasis with no side effects, scientists found.

Psoriasis is a skin condition characterized by the speeding up the life cycle of skin cells, leading to the formation of scales and red patches that are itchy and sometimes painful.

Most common causes of psoriasis is a skin infection with an autoimmune disorder caused by the immune system attacking the skin tissue after bacterial and virus invasion or skin injury due to cut or scrape, an insect bite, or a severe sunburn.

Some researchers believe that the disorder can also be driven by the change of weather, illness, or stress.


Similar to other types of inflammation, it is a result of overexpression of the inflammatory cytokines produced during the course of skin injury and damage, leading to the death and damage of the skin cells that cause of skin cells in the affected area to turn over at a significantly faster rate than normal.


Several risk factors, according to epidemiological studies such as infection, skin injury, smoking, being overweight or obese and long-term use of certain medications including beta-blockers used for the treatment of hypertension are involved in the initiation and progression of psoriasis.


Genetic preposition such as HLA-C06:02 environmental and lifestyle factors, such as certain foods and infections, are some risk factors of psoriasis.

According to statistic, these people have a 30% increased risk for the development of the condition.


Therefore, identifying the trigger potentials may be important for these patients to develop strategies the management and prevention of psoriasis.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

With an aim to find a natural ingredient or herbal medicine for the treatment of psoriasis, with no side effects, researchers evaluated the Aloe vera gel, used traditionally for the treatment of skin diseases, including psoriasis, through assessing the ethanolic extract of the gel in a mouse tail model of psoriasis.

The extract displayed a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%).


Furthermore, the extracted gel was found to be equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis.

Moreover, the ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, and no change in the standard tazarotene.

Dr. Dhanabal SP, the lead scientist said, "the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis".


Additionally, in the examine the topical aloe vera (AV) used to treat various skin conditions, including psoriasis, researchers launched a randomized, comparative, double-blind, 8-week study.

80 patients included in the randomized study received AV or 0.1% TA cream.


The patient's clinical responses were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI).

After 8 weeks of treatment, researchers discovered the mean PASI score decreased from 11.6 to 3.9 (-7.7) in the AV group and from 10.9 to 4.3 (-6.6) in the TA group. Between-group difference was 1.1 (95% confidence interval -2.13, -0.16, P = 0.0237.


And, the mean DLQI score decreased from 8.6 to 2.5 (-6.1) in the AV group and from 8.1 to 2.3 (-5.8) in the TA group.

Between-group difference was 0.3 (95% confidence interval -1.18, -0.64, P = 0.5497).

In the final report, Dr. Choonhakarn C, the lead scientist wrote, "AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis".


The findings suggested that herbal Aloe vera may be considered a functional remedy of the treatment of psoriasis topically with no side effects.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.




References
(1) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(2) A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)