Herbal Bilberry May Process Anti Leukemia Potency, Studies Revealed

Bilberry may have a strong and positive effect in reducing risk and treatment of leukemia with no side effects, according to studies.

Leukemia is chronic and medical condition arisen by the blood-forming tissues, including the bone marrow and the lymphatic system.

According to the statistic provided by the US Leukemia and Lymphoma Society, leukemia, lymphoma, and myeloma cause the deaths of an estimated 58,100 people in the US in 2018, accounting to 9.5 percent of the deaths from all cancers in 2018.

The causes of leukemia are unknown. However, some researchers suggested that family history, smoking habit, genetic disorder syndrome, a blood disorder, exposure to radiation and toxic chemical and previous cancer treatment are some prevalent risks of the cancer onset.

However, most people exposed to some of the aforementioned risk factors have never developed leukemia.


Besides general symptoms of cancer, patients also experience symptoms related to the immune system such as easily bleeding, frequent infection.

Acute myelogenous leukemia (AML) is one of the most common forms of leukemia, affecting both children and adults.

The five-year survival rate for AML is 26.9 percent.

Some researchers suggested that genetic preposition may have a strong implication to induce the onset of acute myeloid leukemia (AML) as most of the cancer is found in the children.


Dr. Hamerschlak N, in the assessment of the genetics and prognostic factors of leukemia, said, " In chronic myeloid leukemia, clonal evolution is associated with progression to the blast crisis. Patients on imatinib who cease responding may have mutations on their ABL gene. Finally, in acute lymphoblastic leukemia, factors such as hyperdiploidy and t 12:21 are associated with good prognosis, whereas carriers of t 4:11 and t 9:22 are considered high-risk patients".

The results strongly suggested that if you carry any genetic preposition associated with the risk of leukemia, please have blood test annually for preventive measure.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists on finding potential and natural compound for the treatment of leukemia evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells.

The study is to compare the B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects.

Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells but little or no effect in PBMCs.


The main phenolic compounds of the bilberry extract are delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside induced cancer cell death through the pro-apoptotic effect.

The efficacy of Antho 50-induced apoptosis was attributed to activated the protein associated with programming cell death and inhibited the gene associated with cancer proliferation.

Furthermore, Antho 50 significantly induced PEG-catalase-sensitive in the generation of reactive oxygen species in B CLL cells, leading to cytotoxicity.


The findings suggested that bilberry exhibited anti-leukemia activity through several mechanisms, including cell death pathways.


In order to reveal more information about bilberry in the inhibition of leukemia, researchers compared the anticancer effect of ethanol extracts of 10 edible berries.

Bilberry extract was found to be the most effective at inhibiting the growth of HL60 human leukemia cells through apoptotic cell bodies and cell degradation in vitro.

The antileukemia effects of bilberry extract probably were attributed to the contents of phenolic compounds, including anthocyanins, which showed a significant radical scavenging activity which has been found to protect the integrity of the cell against DNA alternation.

Moreover, pure delphinidin and malvidin isolated from the bilberry extract also found to induce apoptosis in HL60 cells.

Dr. Katsube N and colleagues wrote, " the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis" in the final report.

Taken altogether, bilberry processed a high amount of bioactive compounds may be considered a functional remedy for the prevention and treatment of leukemia, pending to the confirmation of larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway by Alhosin M1, León-González AJ1, Dandache I1, Lelay A2, Rashid SK1, Kevers C3, Pincemail J4, Fornecker LM5, Mauvieux L6. (PubMed)
(2) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins by Katsube N1, Iwashita K, Tsushida T, Yamaki K, Kobori M. (PubMed)
(3) Leukemia: genetics and prognostic factors. [Article in English, Portuguese] by Hamerschlak N1. (PubMed)