Eyebright ( Euphrasia) Demonstrates Antihyperglycemic Activity in Vivo

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

In other words, hyperglycemia is a hallmark in patients with diabetes, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms of shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Over the long-term, persistently mild hyperglycemia can lead to complications in the eyes, kidneys, and nerve damage and heart disease, and stroke.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.


The most common causes of hyperglycemia are associated with an uncontrolled diet, improper use of insulin, and skip diabetic medication.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. In severe cases, some patients may also experience symptoms of headaches, trouble concentrating, and blurred vision.


On finding a natural ingredient for the prevention and treatment of high blood glucose, scientists examined the effects of the aqueous extract of the leaf of Euphrasia officinale.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.


The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

The study included selected rats that were assigned to healthy normal or alloxan-induced diabetic rats

According to tested analysis and compared to the levels of blood glucose levels in normal and alloxan-diabetic rats

* Treatment of alloxan-induced diabetic rats showed a strong effect by bringing down the raised glucose levels,

* The extract administration exerted a significant activity against hypoglycemia in normal and diabetic induced rats.

In other words, the aqueous extract of the leaf of Euphrasia officinale. not only has a strong activity against levels of blood glucose but also ameliorated the hyperglycemia in diabetic experimental rats.


Taken altogether, Eyebright (Euphrasia)may be considered a remedy for the treatment of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihyperglycemic activity of Euphrasia officinale leaves by Porchezhian E1, Ansari SH, Shreedharan NK. (PubMed)

Herbal Devil's Club Kills Human Pancreatic Cancer Cells In Vitro

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.

At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.


The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon and breast cancers.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even diagnosed early is very low compared to other types of cancer.

The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.

Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).

Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.

Devil's Club (DC) is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America.

The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

On finding a potential compound for the treatment of cancer, researchers examined the effects of DC 70% ethanol extract alone, or in combination with cisplatin, gemcitabine, and paclitaxel on pancreatic endocrine HP62 and pancreatic ductal carcinoma PANC-1 and BxPC-3 cells.


According to the tested differentiation,* DC extract inhibited proliferation of HP62 with IC50 (50% inhibition concentration) at 0.037±0.002% (v/v), PANC-1 at 0.0058 ± 0.0004% and BxPC-3 at 0.021 ± 0.003%.

* DC at 0.0033% combined with 1 nM of paclitaxel showed inhibition synergy on PANC-1 cells with a combination index of 0.44.

* Increased cytochrome C, claspin, cIAP-2, and HTRA2/Omi apoptosis-related markers were upregulated in DC-treated HP62 and PANC-1.

Collectively, researchers suggested, "DC acts through targeting the intrinsic mitochondrial apoptosis pathway in the pancreatic cancer cells.

And, "The high antiproliferation potency of DC on PANC-1 is potentially useful as an adjunct therapy for treating pancreatic cancer, which is known for developing resistance to conventional chemotherapeutics".

Taken altogether, Devil's Club may be considered a remedy for the treatment of pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound by Cheung SS1, Tai J, Hasman D, Ou D, Warnock GL. (PubMed)

Tocopherols Deficiency In the Risk of Age-Related Macular Degeneration

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increase in size.

The advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.


Age-related macular degeneration can be classified into 2 types
* The common AMD is the dry form caused by the gradual degeneration of the central retinal tissues, affecting 90% of patient s with AMD. Some patients with the dry form of AMD have been found to develop into the wet form over time.

* The wet form of AMD is caused by the breaking of capillary under the macula, accounting for only 10% of AMD.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of degenerative diseases, researchers compared the effects of dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene on age-related macular degeneration.

According to the results of a brief-type self-administered questionnaire of the case-control study that reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) from of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects in Japan,
* Low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD.

In other words, low levels of serum of tocopherols were associated with increased risk of AMD.

* There was no association with retinol or cryptoxanthin intake and neovascular AMD.

These results were adjusted based on smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption


Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of AMD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan by Aoki A1,2, Inoue M3, Nguyen E4, Obata R1, Kadonosono K3, Shinkai S2, Hashimoto H5, Sasaki S4, Yanagi Y. (PubMed)

Herbal Cramp Bark (Viburnum opulus), the Potential Acetylcholinesterase Inhibitor

The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

Acetylcholinesterase (AChE) is the primary enzyme that hydrolyzes the neurotransmitter acetylcholine to choline and acetate.

Altered levels of ACh in the nervous system have been found to induce several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington, depending on the affected areas.

Butyrylcholinesterase (BuChE) enzyme plays a minor role in regulating brain acetylcholine (ACh) levels.

A cholinergic neuron is a nerve cell which mainly is used by the neurotransmitter acetylcholine (ACh) to send its messages

Impairment of the cholinergic neuronal system in the brain was involved in the underlying event of cognitive impairment.
Cholinesterase inhibitors (ChEI) has been used for the treatment of Alzheimer's disease (AD).

Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.


On finding a potential herbal medicine for the prevention and treatment of associated with neurodegenerative diseases, researchers examined ethyl acetate, methanol, and water extracts prepared from the branches, leaves, and fruits of Viburnum opulus and Viburnum lantana along with salicin on acetylcholinesterase (AChE) inhibitory and antioxidant activities.

In vitro, according to the results from an enzyme-linked immunosorbent assay, the leaf methanol extract of V. opulus displayed a significantly high inhibitory effect against AChE at 50, 100, and 200 μL/mL concentrations of 57.63%, 87%, and 93%, respectively compared to other extracts.

In other words, the leaf methanol extract of V. opulus showed the highest protective activity against the disruption of neuron in the induction of neurodegenerative diseases linearly in a doses dependent-manner.

Compared to Viburnum opulus, the extracts of V. lantana exerted higher antioxidant activity.

Taken altogether, cramp bark(Viburnum opulus) leaves may be considered a functional acetylcholinesterase inhibitor herb medicine for the prevention and treatment of neurodegenerative diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents by Erdogan-Orhan I1, Altun ML, Sever-Yilmaz B, Saltan G. (PubMed)

Herbal Elecampane (Inula helenium) Induces Acute Lymphoblastic Leukemia Cell Apoptosis

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.


Bone marrow is the soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

According to the statistics provided by the leukemia research, leukemia is diagnosed 10 times more often in adults than children. Approximately, each year the disease causes death 68,000 Americans.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream into other parts of the body, including tissue and organs, including
*Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer of the abnormal growth of extremely immature lymphocytes overproduced by the bone marrow and/or lymphatic system.

All have a tendency to multiply quickly, it can lead to the death of other normal white blood cells in the bone marrow and/or lymphatic system. In ALL, lymphocytes appear immature in the bloodstream.
Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

*Acute myelogenous leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining cause of the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

On finding a natural ingredient for the prevention and treatment of leukemia, scientists examined the antitumor effect of Alantolactone (ALT), an active component of natural product Inula heleniumin on B cell acute lymphoblastic leukemia (B-ALL).

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.


The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to the tested analysis of B-ALL cells that were treated with various concentrations of ALT,

* ALT showed a good antitumor effect in B-ALL by inducing cytotoxicity.
* In vivo and in vitro, ALT induced the overexpression of ROS to cause cancer apoptosis by damaging the cancer cell DNA damage.

* In addition, the induction of over a load of ROS by ALT was attributed to the effects in the direct inhibition of reductase.

Based on the results, researchers suggest, "We found that ALT, a natural product, showing a promising tactic in the therapy of B-ALL by targeting ROS pathway".


Taken altogether, Dandelion may be considered a remedy for the treatment of acute lymphoblastic leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells by Xu X1, Huang L2, Zhang Z1, Tong J1, Mi J1, Wu Y3, Zhang C4, Yan H. (PubMed)

Healthy Foods Broccoli May Process Anti-Influenza Virus Properties

Influenza also known as "the flu", is an infectious disease caused by an influenza virus.

In other words, flu (influenza) is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses) that can lead to symptoms of chills, fever, sore throat, muscle pains, severe headache, coughing, etc.


There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of the general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.

However, people with the immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.


The most common H and N subtype are influenza A that has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 became the first flu pandemic in the world that causes respiratory illness.

* H5N1 - Bird Flu
H5N1 is the strain of influenza known as a bird or avian flu. Before, it is transmitted between birds, but today, it now can be passed from bird to human. The strain is dangerous to humans with high death rates.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of viral diseases, researchers examined the effects of broccoli sprout homogenates (BSH) on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers.


The randomized, double-blind, placebo-controlled trial included healthy young adult smokers and nonsmokers ingested BSH or placebo (alfalfa sprout homogenate) for 4 days, designated Days -1, 0, 1, 2. and on day 0 they received a standard vaccine dose of live attenuated influenza virus (LAIV) intranasally.
According to the tested analysis,
* In the area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01) were significantly reduced in NLF from BSH-treated smokers.

* However, In nonsmokers, a similar trend for reduction in virus quantity with BSH did not reach statistical significance.

In other words, in smokers, short term ingestion of broccoli sprout homogenates appears to significantly reduce some virus-induced markers of inflammation, and virus quantity compared to less significant in non-smokers.

Based on the results, researchers wrote, " Nutritional antioxidant interventions have promise as a safe, low-cost strategy for reducing influenza risk among smokers and other at-risk populations".
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".

In other words, SFN protected the integrity of the neurons against neuron damage through it's anti-neuroinflammatory and neuroprotective activities.

Taken altogether, broccoli sprouts may be considered supplements for the prevention of influenza, pending to the confirmation of the larger sample size and multicenter human study.


Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study by Noah TL1, Zhang H2, Zhou H2, Glista-Baker E3, Müller L4, Bauer RN5, Meyer M6, Murphy PC7, Jones S3, Letang B8, Robinette C3, Jaspers I. (PubMed)

Omega 3 Fatty Acid Inhibits the Onset of Fatal Coronary Disease in Cohosts

Cardiovascular disease is a medical condition that affects the cardiovascular system, including the heart, blood vessels(arteries and veins).

Coronary heart disease (CHD) is a condition of narrowing coronary arteries that lead to blockage of the blood flow in the arteries caused by hardening arterial wall, cholesterol building up in the arteries, chemicals, such as cadmium clog up arteries, etc. affecting the small blood vessels that supply blood and oxygen to the heart.

Acute coronary syndrome is a medical emergency caused by suddenly reduced blood flow to the heart, leading to heart muscle damage and brain apoptosis, depending on the affected location.


Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.

According to the statistics, approximately 1 of every 13 Americans aged 18 years and older are living with coronary artery disease. CHD is a leading cause of death in the ethnic group in the US, particularly in Hispanic Americans.

Believe it or not, CHD is predicted by scientists to become the most common cause of death worldwide by 2020.

Although CHD is a lowly progressive disease, the disease may become clinically apparent by age 40. People 65 years of age and older have been found in most patients with CHD.

Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of coronary artery disease, chest pain or discomfort, pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.

Coronary heart disease (CHD) is the leading cause of death in the United States.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of heart disease researchers examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD).
,
According to the results of the study of the data10 of the cohorts,
* The overall mean (SD) for the Omega-3 Index in these 10 cohort studies was 6.1% (2.1%), and

* The HR for a 1-SD increase was 0.85 (95% confidence interval, 0.80-0.91).

* The median quintiles 1 and 5 levels were 4.2% vs. 8.3%, respectively.

* Based on these values, we estimate that the risk for fatal CHD would have been reduced by about 30% moving from an Omega-3 Index of 4%-8%.

Moreover, researchers said, "These findings support the use of <4% and >8% as reasonable therapeutic targets for the Omega-3 Index".


Taken altogether, Omega-3 fatty acids may be considered a remedy for the prevention and treatment of fatal coronary disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies by Harris WS1, Del Gobbo L2, Tintle NL. (PubMed)

Tocopherols Suppress the Onset of Metabolic Syndrome

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndrome, you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

Symptoms of signs of metabolic syndrome depending on the types of affected conditions and complications.


The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in a high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.

Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.


Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of α- and γ-tocopherol levels on metabolic syndrome.

According to the analysis of the magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women),
* The α- tocopherol/cholesterol ratio was positively associated with VAT (β scaled by the interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR) Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile).


* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), visceral (VAT) (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* Finally, α- and γ-tocopherol levels were positively associated with high triglycerides and low high-density lipoprotein cholesterol levels (all Ptrend < 0.05).

After talking about other factors into account, researchers said, "Circulating vitamin E levels displayed strong associations with VAT and MetS".


Taken altogether, tocopherols used regularly may be considered adjunct therapies for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content by Waniek S1, di Giuseppe R2, Plachta-Danielzik S3, Ratjen I4, Jacobs G5,6, Koch M7,8, Borggrefe J9, Both M10, Müller HP11, Kassubek J12, Nöthlings U13, Esatbeyoglu T14, Schlesinger S15, Rimbach G16, Lieb W. (PubMed)

Brassica Genus Inhibits the Epstein-Barr Virus (EBV)-Positive Burkitt's Lymphoma

Herpesvirus is a large family of DNA viruses that cause diseases, depending on types of viral infection.

According to viral classification, there are 8 types of the herpes virus, including human herpesvirus 1 that causes cold sores around the mouth. and 2 that causes genital herpes, herpes zoster that causes chickenpox and shingles, Epstein-Barr virus that causes infectious mononucleosis, cytomegalovirus (CMV) that causes mononucleosis, Human herpesvirus 6 and 7(HHV6 - 7) that causes roseola and Human herpesvirus 8 (HHV8) that causes cancer, such as Kaposi's Sarcoma.

According to statistics, in the United States, half of teens and adults under age 50 are still infected with the oral herpes virus, and about 1 in 8 have an infection with the genital herpes virus.

All herpesviruses like other viruses are nuclear-replicating, infecting healthy cells nucleus through replication of viral DNA and transcription of viral mRNA.

People infected may experience symptoms of painful sores in the genital area, anus, buttocks, thighs, itching, painful urination, vaginal discharge,..... and tender lumps in the groin.

Epstein-Barr virus (EBV)-positive is early in the course of the illness associated with VCA-IgM antibodies caused by EBV infection.

The Epstein–Barr virus (EBV), is also known as human gammaherpesvirus 4, one of the nine known human herpesvirus types in the herpes family.

Unlike other types of the herpes virus, symptoms of EBV may vary, including extreme fatigue, fever, sore throat, and swollen lymph nodes.

Conventionally, there is no specific treatment for EBV. The most common treatment is to improve quality of life by targeting symptoms such as reducing swelling of tissues with corticosteroids

On finding a potential plant with infectious diseases, researchers compared the effects of indole-3-Carbinol (I3C) is a natural product found in broadly consumed plants of the Brassica genus, such as broccoli, cabbage, and cauliflower, effects on various vegetablesEpstein-Barr virus (EBV)-positive

Based on the tested results, I3C efficiently induced apoptosis in cell lines derived from EBV-positive Burkitt's lymphomas (virus latency I/II).


However, I3C did not have any cytotoxic activity against EBV-negative Burkitt's lymphomas and immortalized EBV-infected lymphoblastoid cell lines (virus latency III).


Furthermore, The effect of I3C on cell viability. in EBV-positive Burkitt's lymphoma was attributed to C6-methylated derivative, but not other 3-substituted indoles.

Moreover, 3C treatment caused apoptosis characterized by loss of cancer cell mitochondria membrane potential and caspase activation by alternating the expression of proteins involved in the control of apoptosis and transcription regulation in EBV-positive Burkitt's lymphoma cell lines.

Particularly, I3C derivative 3,3'-diindolylmethane (DIM) prolonged survival and reduced tumor burden of mice xenotransplanted with EBV-positive Burkitt's lymphoma Daudi cells.

Based on the results, researchers said, "these results, together with previous reports from clinical trials indicating the lack of toxicity in humans of I3C and derivatives, support the use of these compounds as a new therapeutic approach for treating patients with endemic (EBV-positive) Burkitt's lymphoma".

Taken altogether, Brassica Genus may be considered anti the Epstein-Barr virus (EBV)-positive induced cancer remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines by Perez-Chacon G1, de Los Rios C2, Zapata JM. (PubMed)

Tocopherols Reduce the Risk and Progression of Prostate Cancer in Vivo

The prostate gland wrapped around the around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder.

The prostate gland is a gland that makes and stores semen. It is located below the bladder and surrounds the tube that carries urine out of your body.

Additionally, the muscles of the prostate gland also play a critical role in propelling seminal fluid into the urethra during ejaculation

Symptoms of an enlarged prostate are associated with a naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate.

Prostate cancer is a medical and chronic condition that caused the growth of the cells irregularly in the tissue of the prostate.

Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland.
According to the statistic provided by the Canadian Cancer Society, prostate cancer is the third most common cancer among Canadian men and the 3rd leading cause of death from cancer in men in Canada.

In 2017, approximately 21,300 men were diagnosed with prostate cancer, accounting for 21% of all new cancer cases in men.

Furthermore, approximately 1 in 7 Canadian men will develop prostate cancer during his lifetime and 1 in 29 will die from it.

The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%.

In other words, For men diagnosed with prostate cancer that has not spread to other parts of the body, the 5-year survival rate is 100%.

However, the 5 years survival rate of prostate cancer that has spread to other parts of the body, is only 30%.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of tocopherols on prostate cancer.

The study included specific Pten-/- (Ptenp-/-) mice induced cancer by activation of AKT cancer promotion signaling, fed by Ptenp-/- mice with AIN93M or 0.2% δ-T supplemented diet, at the age of 6 or 12 weeks. According to the analysis,
* δ-T treatment reduced prostate adenocarcinoma multiplicity at the age of 40 weeks by 53.3 and 42.7%, respectively.

* Furthermore, the phosphorylation of AKT (T308) that promotes cancer growth and survival was reduced in the prostate of the mice administered the δ-T diet.

* δ-T diet also, reduced proliferation and increased apoptosis were in the prostate cancer cell line without affecting the oxidative stress.

Interestingly, α-tocopherol (α-T) at 0.2% in the diet exhibited anti-prostate cancer cell activity with no effects on prostate adenocarcinoma multiplicity in the Ptenp-/- mice.

After talking about other factors into account, researchers said, " δ-T inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, mainly through inhibition of AKT activation".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies by Key TJ1, Appleby PN2, Travis RC2, Albanes D3, Alberg AJ4, Barricarte A5, Black A3, Boeing H6, Bueno-de-Mesquita HB7, Chan JM8, Chen C9, Cook MB3, Donovan JL10, Galan P11, Gilbert R10, Giles GG12, Giovannucci E13, Goodman GE14, Goodman PJ15, Gunter MJ16, Hamdy FC17, Heliövaara M18, Helzlsouer KJ19, Henderson BE20, Hercberg S11, Hoffman-Bolton J21, Hoover RN3, Johansson M22, Khaw KT23, King IB24, Knekt P18, Kolonel LN25, Le Marchand L25, Männistö S18, Martin RM26, Meyer HE27, Mondul AM3, Moy KA3, Neal DE28, Neuhouser ML29, Palli D30, Platz EA31, Pouchieu C12, Rissanen H18, Schenk JM32, Severi G12, Stampfer MJ13, Tjønneland A33, Touvier M11, Trichopoulou A34, Weinstein SJ3, Ziegler RG3, Zhou CK3, Allen NE35; Endogenous Hormones Nutritional Biomarkers Prostate Cancer Collaborative Group. (PubMed)
(2) δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice by Wang H1, Yang X1, Liu A1, Wang G2, Bosland MC3, Yang CS. (PubMed)

Herbal Angelica Sinensis Induces Weight Loss in Obesity

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

Most common causes of obesity are associated with
* An increased intake of energy-dense foods that are high in saturated and trans fat, processed foods and red meat.

* An increase in physical inactivity.

That leads to the accumulation of visceral fat in the body.


Visceral fat in obesity is associated with 90% of patients with ischemic heart disease. In obese, the accumulation of visceral fat is predominant in the intra-abdominal cavity.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity rates have increased for all age groups in the US over the last several decades, coincidently with the periods that promoted the Western diet.

The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with the development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".

Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition, and use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants, or some seizure medications, also increases the risk of overweight and obesity.


On finding a natural ingredient for the prevention of overweight, scientists examined the root of Angelica sinensis (RAS) supplementation effects on FTO gene expression and methylation status in body weight on an animal model,

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis, of high-fat-diet (HFD) induced obese female mouse that were divided into groups according to RAS dosage in the diet as follows: normal diet, HFD diet (HC), HFD with low-dosage RAS (DL), HFD with medium-dosage RAS (DM), and HFD with high-dosage RAS (DH). After RAS supplementation for 4 weeks,
* Bodyweight suppression and FTO expression associated with reduced weight in DH mice were significantly higher compared to HC mice and no significant change in FTO expression was detected between DM and DL mice or in their offspring.

* Furthermore, CpG island (the regions with a high frequency of CpG sites) in the FTO promoter was hypermethylated up to 95.44% in the HC group, 91.67% in the DH group, and 90.00% in the normal diet group.

* Most importantly, the adipocyte expression in the DH group were smaller than those in the HC group.

These results strongly suggested that RAS may have a potential role in the inhibition of obesity.

Based on the results, researchers suggest, "RAS could ameliorate obesity-induced by HFD and that the molecular mechanism might be associated with the expression of the FTO gene".

Taken altogether, Dandelion may be considered a remedy for the treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis Suppresses Body Weight Gain and Alters Expression of the FTO Gene in High-Fat-Diet Induced Obese Mice by Zhong T1, Duan XY1, Zhang H1, Li L1, Zhang HP1, Niu L. (PubMed).

Herbal #Angelica Sinensis, the Natural Anticancer Herbal Remedy

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer".

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.


The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The prevalent factors associated with the risk of cancer are age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression.

Cancers are the second leading cause of death worldwide besides heart diseases. Believe or not, 1/4 of cancers death are due to lung cancer.


On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined Radix Angelica Sinensis (Danggui in Chinese) is widely used in traditional Chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in Dangui, is a potential antitumor agent for various cancer types.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.


According to the experimental results,* Danggui users were found to have an increased survival rate when compared with Danggui nonusers (log-rank test p = 0.002).

* The use of Danggui highly associated with decreased mortality (the adjusted hazard ratio (HR) of Danggui user was 0.72 [95 % CI, 0.57-0.92] (p = 0.009).

* The in vitro results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.
* According to the RNA-seq analysis, BP induced an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth.

* BP suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells".

Taken altogether, Dandelion may be considered anti-cancer activity, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

Eyebright (Euphrasia), A Natural Antimicrobial Herbal Medicine

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites, or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

Conventionally, most cases of infectious diseases except those caused by viruses are treated by antibiotics.

Microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organisms, including a bacterium, virus, or fungus.

Believe or not, single-celled like bacteria, algae, and protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environments.

And less than 1% of bacteria, can invade and cause infection and diseases.

Although the discovery of human antibiotics is medicines that kill or slow the growth of bacteria, however, overuses of the antibiotics have been found to induce microbial resistance to certain drugs.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the antimicrobial effects on the essential oil extracted from Eyebright, Euphrasia rostkoviana Hayne (Scrophulariaceae).

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.


The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to the analysis of eye infections induced by Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, and Candida albicans,
* 70 constituents isolated from the essential oil that inhibited infection, the n-hexadecanoic acid (18.47%) was the main constituent followed by thymol (7.97%), myristic acid (4.71%), linalool (4.65%), and anethole (4.09%).

* The essential oil showed antimicrobial effect against all organisms tested with the exception of P. aeruginosa.

* Most importantly, the best activity was observed against all Gram-positive bacteria tested with the minimum inhibitory concentrations of 512 µg/mL.

Based on the results, researchers suggest, "This is the first report on the chemical composition of E. rostkoviana essential oil and its antimicrobial activity".

Taken altogether, Eyebright (Euphrasia) may be considered a remedy for the treatment of microbial infection, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Composition and Antimicrobial Activity of Euphrasia rostkoviana Hayne Essential Oil by Novy P1, Davidova H1, Serrano-Rojero CS1, Rondevaldova J2, Pulkrabek J3, Kokoska L. (PubMed)

Omega-3 Fatty Acids Promotes Neuro-Functioning After Ischemic Stroke

Cardiovascular diseases refer to heart diseases and stroke, affecting millions of people in the world.

According to statistic, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.


In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention is most cases can minimize brain damage and potential complications.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.



There is a general belief that stroke is an accumulation over a long period of the unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke in which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of mega-3 polyunsaturated fatty acids (n-3 PUFAs) in alleviating ischemic brain injury in young adult rodents.

The study included aged (18-month-old) mice which were administered n-3 PUFA-enriched fish oil in daily chow for 3 months before and up to 8 weeks after 45 minutes of transient middle cerebral artery occlusion (tMCAO).
According to the results of differentiation,
* Mice receiving dietary supplementation of n-3 PUFAs for 3 months showed significant increases in brain ratio of n-3/n-6 PUFA contents.

* Furthermore, the administration of dietary supplementation of n-3 PUFAs for 3 months also markedly reduced long-term sensorimotor deficits and chronic ischemic brain tissue loss after tMCAO.

* Moreover, n-3 PUFAs robustly promoted post-ischemic angiogenesis and neurogenesis to enhance the brian neuron activity and enhanced white matter integrity after tMCAO.

* Most importantly, the enhancement of neurogenesis and white matter integrity were both correlated positively with the improvement of sensorimotor activities after tMCAO.

Collectively, researchers said, "prophylactic dietary supplementation of n-3 PUFAs effectively improves long-term stroke outcomes in aged mice, perhaps by promoting post-stroke brain repair processes such as angiogenesis, neurogenesis, and white matter restoration".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the improvement of long-term stroke outcomes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids by Cai M1, Zhang W1, Weng Z2, Stetler RA1,2,3, Jiang X2, Shi Y2,3, Gao Y1,2, Chen J. (PubMed)
(2) Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts by Saber H1, Yakoob MY1, Shi P1, Longstreth WT Jr1, Lemaitre RN1, Siscovick D1, Rexrode KM1, Willett WC1, Mozaffarian D. (PubMed)

Gamma-Linolenic Acid Inhibits of Colonic Inflammation in Vivo

Colonic inflammation is a condition associated with inflammation of the colon of the digestive system.

Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.

In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injured area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.

Inflammation can be classified into
* Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

* Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

On finding a potential plant that processes anti-colonic disease activity researchers examined the relationship between the high-fat, high-sugar diet (HFHSD) and alpha-linolenic acid (ALA) on mouse colitis induced by the administration of trinitrobenzene sulfonic acid (TNBS).

The study included female BABL/c mice which were fed with HFHSD for the 9 weeks. At the same time, ALA treatment (150 or 300 mg/kg) was administered on a daily basis. At the end of the 9 weeks, experimental colitis was induced by the intra-colonic administration of trinitrobenzene sulfonic acid (TNBS).

According to the results of the analysis,
* Before treatment, TNBS induced severe clinical manifestations of colitis and histological damage.
* Low-ALA (150 mg/kg) administration profoundly ameliorated TNBS-induced clinical manifestations, bodyweight loss, spleen weight loss, and histological damage.

* Interestingly, high-ALA (300 mg/kg) administration did not ameliorate colitis and even exacerbated the symptoms.

* HFHSD consumption assisted TNBS in changing IL-12, IFN-γ, IL-2, and IL-17A, the pro-inflammatory cytokines in the liver, and these changes were recovered through low-ALA.


* Moreover, HFHSD had a significant impact on the total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG), which related to the increased risk of hyperlipidemia

Collectively, researchers said, "HFHSD exacerbated the TNBS-induced colitis via the Th1/Th17 (inflammatory) pathway. The Low-ALA (150 mg/kg) exhibited protective effects against the TNBS-induced colitis via the Th1/Th2/Th17 (anti-inflammatory) pathway".

Taken altogether, gamma-linolenic acid may be considered a remedy for the prevention and treatment of colonic inflammation, pending to the confirmation of the larger sample size and multicenter human study.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alpha-linolenic acid given as an anti-inflammatory agent in a mouse model of colonic inflammation by Wen J1,2,3, Khan I1,2,3, Li A1, Chen X4, Yang P1,5, Song P1,5, Jing Y1,2,3, Wei J1,2,3, Che T6, Zhang C. (PubMed)

Omega-3 Fatty Acids Kills Myeloid Leukemia Cells in Vivo

Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Leukemia is a condition of an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is the soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.


Myeloid Leukemia can be classified into acute and chronic
* Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of myelogenous lining cause of the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

* Chronic myeloid leukemia (CML) is a medical condition associated with the overgrowth of immature cells started in the blood-forming cells of the bone marrow.

In other words, compared to normal cells that will die after a limited cell division, chronic myeloid leukemia cells continue to divide with no meaning of dying or stopping, leading to proliferation that affects other healthy cells in the bone marrow.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women. and CML is expected to cause the death of 1,140 people including 660 men and 480 women.

More precisely, CML accounts for 15% of all cases of leukemia diagnosed each year. In other words, the lifetime risk of CML in the US is 1 person in 526.

The 5-year survival rate of patients treated with chemo drug imatinib (Gleevec®) including all stages of CML is 90%.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effects of eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid on myeloid leukemia.

According to the tested analysis in a murine model of chronic myelogenous leukemia (CML) induced by bone marrow transplantation of BCR-ABL-expressing hematopoietic stem cells,
* EPA showed a decrease in the leukemia stem cells (LSC) population and reduced the abnormal enlargement of the spleen and above the normal range in the blood associated with chronic myelogenous leukemia progression, compared to mice treated with an oleic acid diet.

* EPA exerted a similar effect on CML mice carrying the T315I mutation (in BCR-ABL).

* Δ(12)-PGJ3, a derivative of EPA also rescued indomethacin-treated BCR-ABL mice and decreased LSCs.

Based on the findings, researchers said, "EPA supplementation was effective in a murine model of acute myeloid leukemia. EPA-supplemented mice exhibited a decrease in leukemia burden and a decrease in the LSC colony-forming unit (LSC-CFU)".

And, "he results support a chemopreventive role for EPA in myeloid leukemia, which is dependent on the ability to efficiently convert EPA to....Δ(12)-PGJ3".

Taken altogether, Omega-3 fatty acids processed abundantly eicosapentaenoic acid may be considered a functional food for the treatment of myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia by Finch ER1, Kudva AK2, Quickel MD2, Goodfield LL2, Kennett MJ2, Whelan J3, Paulson RF4, Prabhu KS. (PubMed)
(2) n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation by Picou F1, Debeissat C2, Bourgeais J2, Gallay N2, Ferrié E1, Foucault A3, Ravalet N3, Maciejewski A1, Vallet N4, Ducrocq E1, Haddaoui L5, Domenech J2, Hérault O6, Gyan E. (PubMed)

Healthy Food Broccoli's Sulforaphane (SFN) Blocks the Onset of Diabetic Cardiomyopathy in Diabetes

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

Cardiomyopathy is a disease associated with heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.


Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.

The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.

According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.

* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.

* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzyme and decreased the expression in enhancing the initiation of oxidative stress.


* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol and glucose metabolism.


Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.


Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)