Herbal Turmeric Inhibits the Risk of Peripheral Arterial Disease

Peripheral artery disease is a common circulatory condition caused by narrowed arteries that reduce blood flow to your limbs.

Most cases of peripheral artery disease have been associated with the accumulation of plaque in thicking and hardening the arteries, a leading cause of atherosclerosis.

The most common prevalent factors associated with peripheral artery disease are tobacco, physical inactivity, and an unhealthy diet with high in fat, processed food, and red meat and low in fruits and vegetables.

Most patients with peripheral arterial disease are asymptomatic or experience a mild case of pain in the leg while walking. However, as the disease progression, some patients may also experience symptoms of leg numbness or weakness, coldness in your lower leg or foot, sores on your toes, feet or legs that won't heal, a change in the color of your legs, slower growth of your toenails and shiny skin on your legs.

Some men also experience the syndrome of erectile dysfunction in severe cases.

Conventionally, the treatment of peripheral arterial disease is focusing to improve symptoms, such as leg pain, and quality of life and stopping the progression of atherosclerosis associated with the risk of heart attack and stroke, including medication to lower cholesterol, blood pressure and blood sugar.

In some cases, surgery may be necessary to treat peripheral artery disease if patients experience claudication that does not respond to medicine.

Some researchers in the investigation of the effect of the heart-healthy diet on peripheral arterial disease wrote, "Peripheral arterial disease (PAD) is a burdensome cardiovascular condition that results from chronic inflammatory insults to the arterial vasculature".

And, "The nutrients reviewed included omega-3 polyunsaturated fatty acids (n-3 PUFAs), folate and B-series vitamins, and anti-oxidants. The diet plans described include the DASH diet, Mediterranean diet, low-fat diet, low carbohydrate diet, Dr. Dean Ornish’s Spectrum® Diet and Dr. Andrew Weil’s Anti-Inflammatory Diet".

In other words, by changing to a healthy diet with more fruits and vegetables and less red meat, saturated and trans fat, processed foods peripheral arterial disease may be preventable.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.



The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart diseases, researchers examined curcumin treatment improves tissue repair and perfusion recovery in a mouse model of diabetic PAD.

Mice with PAD selected to the study with a normal glycaemic profile treated with curcumin, improved perfusion recovery, observed by the increased capillary density and elevated microRNA (miR)-93 expression in the ischemic muscle tissue.

In vitro, cultured endothelial cells under simulated ischemia, treated with curcumin improved endothelial cell viability and enhanced tube formation.

However, improved endothelial cell viability and enhanced tube formation were inhibited in the presence of the miR-93 inhibitor, regardless of the administration curcumin.

Based on the findings, researchers said, "curcumin had beneficial effects in non-diabetic PAD by improving angiogenesis, which may have been achieved partially via the promotion of miR-93 expression".


Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of peripheral arterial disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin improves perfusion recovery in experimental peripheral arterial diseaseby upregulating microRNA-93 expression by Zhang J1,2, Wang Q1, Rao G1, Qiu J1, He R. (PubMed)
(2) Advancing Beyond the ‘Heart-Healthy Diet’ for Peripheral Arterial Disease by Emily V. Nosova,1,2 Michael S. Conte,1,3 and S. Marlene Grenon. (PMC)