Phytochemical Indicaxanthin Inhibits Factors Associated with Beta Thalassemia Anemia

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.

Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.

Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cells loss.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in heart and other organs, which can lead to heart failure.

The most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.


Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.


In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.

Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.

Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.

According to the A spectrophotometric study, the antioxidant also showed to reduce the reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.

Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)