The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.
Traditional Chinese medicine views the pancreas, a vital organ is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.
More precisely, the functions of the pancreas including the
* Production of enzymes digest fat, protein, and
carbohydrates.
* Production of juices combined with juices from the intestines to break down protein, carbohydrates and fat, therefore, it plays an important role in maintaining good health.
* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.
Pancreatic islets are groups of hormones producing cells, including insulin and glucagon, that work together to maintain the proper level of sugar (glucose) in the blood.
Profound distortion of islet organization in the pancreas has been found to induce account abnormal secretory behavior of the glucagon-secreting A cells in insulin-dependent juvenile-onset diabetes.
Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.
As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the anti-diabetic effects of the extract of A. tenuifolia underground parts and β-sitosterol on rat pancreatic islets.
According to the results of the analysis,* The root extract of the plant and compound β-sitosterol isolated from the root extracts showed moderate α-amylase inhibitory activity.
* Furthermore, the herb root extract was able to increase the secretion of insulin in high concentration (10 mg/mL) and improved the cell viability with no toxicity in all doses.
* The herbal extract could reduce the levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) associated with the onset of oxidative stress in orchestrating damage to the pancreatic islets.
* Moreover, the plant extract also significantly decreased the enzyme activity associated with pro-apoptotic expression by increasing the antioxidant capacity of the isolated cells.
In other words, all compound found in the extract work synergistically to protect the pancreatic islets by inhibiting all parameters involved in pancreatic damage, particularly, the compound β-sitosterol
Taken altogether, beta-Sitosterol combined with other phytochemicals found in A. tenuifolia underground parts may be considered a supplement for the protection of pancreatic islets induced diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Investigation of β-Sitosterol and Prangol Extracted from Achillea Tenoifolia Along with Whole Root Extract on Isolated Rat Pancreatic Islets by Rahimifard M1,2, Manayi A3,2, Baeeri M1, Gholami M4, Saeidnia S3, Abdollahi M. (PubMed)
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