Broccoli' Sulforaphane (SF) Enhances Xenobiotic Metabolism Against the Risk of Cancer

Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.

Other common metabolisms may include
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.

* Drug metabolism is the process to alter chemical of a drug that may cause harm to the body

The gut microbiota plays a critical role in regulating the systemic metabolism of the host including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile by interacting with other organs such as intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.


More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of the dietary nutrients of the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

Imbalance of the ratio of gut microbiota may have a negative impact on human health and diseases.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color, and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.

The study included 16 subjects randomized, into 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.

Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.

Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.

Taken altogether, the consequences of these results suggest that the broccoli process the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)