Cranberry Processes Antibiotic Activity

Antibiotics are a group of conventional medicines used for the treatment of bacterial, fungal parasitic,... infection.

The medications have no effects on viral infection.

Infection is a disease caused by microorganism invasion.

After entering the body, the organisms selectively find a specific tissue or organ to start their multiplication.

Most infectious diseases can be passed from infected person to person or transmitted by bites from insects or animals.

However, the acquired infectious diseases can also be caused by ingesting contaminated food or water or being exposed to organisms in the environment.

Most organisms before having a chance to induce infection are killed off by the immune system response in the acute phase of infection, by stimulating the production of a proinflammatory cytokine.

Unfortunately, if the immune system fails to destroy the invasive organism within a set period of time, normally in a few weeks, it will adapt to the change, causing chronic infection.


Antibiotics have been found to cause digestive discomforts such as nausea, indigestion. vomiting, diarrhea, bloating. the feeling of fullness, and loss of appetite and stomach cramping or pain, acutely.


Chronic use of antibiotics also induces more serious adverse effects, including skin rash, skin allergic reactions, upset stomach, and fungal (yeast) vaginal infections or oral thrush by weakening the immune system.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of infectious diseases, researchers investigated the antibacterial activity of cranberry proanthocyanidin (cPAC) on resistance to tetracycline in Escherichia coli and Pseudomonas aeruginosa.

According to the tested assays, cPAC exerted a potentiating effect, both in vitro and in vivo, on a broad range of antibiotic classes against pathogenic E. coli, Proteus mirabilis, and P. aeruginosa.

cPAC demonstrated the antibacterial effect through two antibiotic resistance mechanisms, namely, selective membrane permeability, and multidrug efflux pumps.


Based on the evidence, researchers said, " The use of cPAC to potentiate antibiotics and mitigate the development of resistance could improve treatment outcomes and help combat the growing threat of antibiotic resistance".

Taken altogether, cranberry may be considered an adjunct therapy as an antibiotic against bacterial pathogens, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram-Negative Bacteria by Maisuria VB1, Okshevsky M1, Déziel E2, Tufenkji N. (PubMed)