Tocopherols Deficiency in the Association with Cognitive Impairment

Cognition is the process of the brain associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.

Cognitive impairment is the condition, affecting a person's thinking, communication, understanding or memory. Cognitive impairment can be acute or chronic.

Acute cognitive impairment is a short-term health problem caused by delirium, an acutely disturbed state of mind due to drugs (toxicity and withdrawal), electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensory input, intracranial urinary retention/fecal impaction or m Myocardial/metabolic/pulmonary.

Chronic cognitive impairment is a permanent medical condition associated with problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

People with mild cognitive impairment (MCI) are at greater risk in the development of dementia, including Alzheimer's Disease.

According to the statistic provided by the Center for Disease Control and Prevention, more than 16 million people in the United States are living with cognitive impairment and these numbers are increasing at an alarming rate.

Sadly, the CDC continued, "An estimated 5.1 million Americans aged 65 years or older may currently have Alzheimer’s disease, the most well-known form of cognitive impairment; this number may rise to 13.2 million by 2050".

The causes of cognitive impairment are unknown. However, researchers suggested that aging, genetically mutated gene inherited from parents, such as Down's Syndrome, Fetal Alcohol Syndrome (FAS), autism, persistent mental health problems, together with unhealthy diet and lifestyle are associated with the onset of cognitive impairment.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of neurological diseases, researchers examined all plasma vitamin E forms on mild cognitive impairment (MCI) and Alzheimer's disease (AD).

The study included 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people.

According to the analysis,
* AD and MCI patients showed lower levels of total tocopherols, total tocotrienols, and total vitamin E, compared to cognitively normal subjects;

* Furthermore, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E.

* Most importantly, both disorders were associated with increased vitamin E damage.

Based on the findings, researchers said, "Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD".

Taken altogether, tocopherols combined with tocotrienols may be considered supplements for the improvement of cognitive impairment in patients with tocopherols and tocotrienols deficiency, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols and tocotrienols plasma levels are associated with cognitive impairment by Mangialasche F1, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. (PubMed)