Genotoxicity is the activity of substances that can cause alternation of DNA of healthy cells to promote irregular cells growth. In other words, genotoxicity is an action that induces cancers.
Genotoxins are gene mutagens which have the property of genotoxicity, including radiation and chemical toxins.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
In rat liver and primary hepatocytes, regular intake of coffee daily illustrated an enormous effect in cellular antioxidant defenses through regulating exhibited enzymes involved mRNA and protein expression.
The study also suggested that coffee and coffee caffeine through the expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrated significant activity in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).
Dr. Cavin C, the lead author said, " the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with protection against various types of chemical stresses".
(Please note that the Nrf2-ARE pathway is an indicator and modulator of oxidative stress)
Other, in the evaluated L5178Y mouse lymphoma cell line to assess the modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
* 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.
*. Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.
* Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.
Dr. Abraham SK, the lead authors said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, a mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".
The Swiss Federal Institute of Technology (ETH), in the study of protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH)(, mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.
Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".
The collective information showed definitive support in use of coffee and coffee caffeine as functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in the treatment of multi types of cancers.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)
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