Broccoli' SFN Protects the Lung Against Lung Cancer in Vitro

The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.

Additionally, the lung also processes other ability in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.

* By removing small blood clots the lung protects the body against the forming air embolisms.

* The airflow produced by the lung also help us to speak.

* The lung also protects the infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

Lung cancer is a chronic and medical condition characterized by abnormal growth of the cells in the lung's tissue.

A most common form of primary lung cancer is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

According to the statistics provided by the American cancer society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of cancer, researchers examined the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) associated with regulation of DNA expression, in two different lung cancer cells by in vitro and in vivo mouse models.

According to the experimental results from A549 and H1299 lung cancer cells were treated with SFN for 48h,

* SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 involved in cell death in all two lung cancer cells.


* Furthermore, SFN induced cancer cells apoptosis, increased the accumulation of cells at G0/G1 and G2/M and arrest cells at S phase.

* Moreover, SFN also suppressed lung cancer growth in a xenograft mouse model in vivo.

Based on the results, researchers wrote, " the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity by Jiang LL1, Zhou SJ1, Zhang XM2, Chen HQ2, Liu W. (PubMed)