Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Chemo-drugs are a class of conventional medicine used for the treatment of cancers. including 5-fluorouracil, 6-mercaptopurine, cytarabine, gemcitabine, and methotrexate.
Compared to other treatments, chemotherapy targets cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival.
Chemo drugs have been found to improve the survival rate of cancer patients. However, they also induce significant side effects.
The most common side effects of chemo-drugs are fatigue, hair loss, easy bruising, and bleeding. infection, anemia (low red blood cell counts) nausea and vomiting, appetite changes, and constipation.
The side effects of chemo drugs are the results of damage to the healthy blood-forming cells in the bone marrow, hair follicles, and cells in the mouth, digestive tract, and reproductive system.
According to the American Cancer Society, some chemo drugs have also been found to damage cells in the heart, kidneys, bladder, lungs, and nervous system.
Chemoprevention is the use of a medication, vitamin, or supplement to prevent the initiation of cancer.
On finding a potential plant for the treatment of cancers, researchers compared the effects of
Brassica family of cruciferous vegetables such as broccoli is a rich source of isothiocyanates, sulforaphane (SFN) as chemopreventive phytochemical.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
According to the differentiation, sulforaphane (SFN) exerted its potent chemopreventive agent based on its ability to target multiple mechanisms within the cell to control carcinogenesis.
More precisely, anti-inflammatory, pro-apoptotic, and modulation of histones are some of the more important and known mechanisms by which SFN demonstrates chemoprevention.
Furthermore, The effect of SFN on cancer stem cells is another area of interest that has been explored in recent years and may contribute to its chemopreventive properties.
Based on the results, researchers said, "In this paper, we briefly review structure, pharmacology and preclinical studies highlighting chemopreventive effects of SFN".
Taken altogether, broccoli consists of SFN may be considered a chemopreventive functional food, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review by Bayat Mokhtari R1,2,3,4, Baluch N5, Homayouni TS6, Morgatskaya E6, Kumar S6, Kazemi P6, Yeger H. (PubMed)https://www.ncbi.nlm.nih.gov/pubmed/28735362
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