Healthy Legume Pinto Bean's Lectin, the Anti Cancer Cell Proliferative Antioxidant

Proliferation is a process of cancer growth associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.


Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.


The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Cancer cell proliferation by dividing unlimitedly, compared to normal cells that die after a certain cell cycle division.


More precisely,
* The growth of normal cells

Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells is back to a normal rate again due to our body growth inhibitors.

Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.

*The primary tumor; size and growth

A primary tumor or original tumor that the tumor progression that yields a cancerous mass.

Some cancers can begin in several places, such as lymphomas and leukemias. Most cancers can not be detected until they formed a small grape-like lump.

Cancer cells need 42 doublings before it can produce enough cancer cells to cause death.

According to the statistics provided by the National Cancer Institute, In 2018, approximately 1,735,350 cases of cancer were diagnosed in the US and the disease also caused the death of 609,640 Americans.

On finding a natural ingredient for the prevention and treatment of cancers, scientists examined the antiproliferative effects of Lectins (hemagglutinins) from the common edible bean Phaseolus vulgaris cv. Hokkaido large pinto bean.

Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to the tested analysis of a 60 kDa dimeric hemagglutinin with a blocked N-terminus was isolated in large yield (190 mg/60 g) from the pinto beans,

* The administration of 60 kDa showed an inhibitory proliferation of nasopharyngeal carcinoma (CNE2), human breast cancer (MCF7), and hepatoma (HepG2) cells.

* The IC50 values were considered relatively low among lectins of different P. vulgaris cultivars toward HepG2, MCF7, and CNE2 cells after treatment for 48 h were 8.1, 6.07, and 7.49 μM, respectively,

In other words, the lectin found in the pinto bean as sugar-binding proteins or glycoproteins with various biological activities exerted a promising remedy for the treatment of cancers in vitro.

Taken altogether, Pinto beans may be considered a promising anti proliferative functional food, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Isolation of a Hemagglutinin with Potent Antiproliferative Activity and a Large Antifungal Defensin from Phaseolus vulgaris cv. Hokkaido Large Pinto Beans by Yin C1, Wong JH1, Ng TB. (PubMed)