Green Bean Promotes Anti- Colon Cancer Activity in Vivo

Cancer is a class of diseases characterized by cell growth irregularly in the tissue of specific organs.

Most cases of primary cancer start in the cells on the surface of the inner lining of specific tissues and organs, before penetrating into deeper layers to form a tumor.

At the advanced stage, the most malignant cancer cell can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis through blood and fluids circulation.


The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colon cancer is a chronic condition caused by irregular cell growth in the colon tissue. Most cases of colon cancer start with the alternation of cells DNA on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor.

Colon cancer is relatively very common, slowly growing and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.

The lifetime risk of colon cancer developing is approximately 1 in 23 for men and women, including 71% of colon and 29% of rectal cancer. Believe it or not, only 39% of colon patients are diagnosed with localized-stage disease.

The exact causes of colon cancer are unknown. However, some researchers suggested the promotion of a high-fat diet over the past few decades may have a strong impact on the induction of colon cancer developing.


Dr. Milly Ryan-Harshman said, "Consumption of red meat might be related directly to the incidence of CRC or indirectly because a diet high in meat tends to be low in vegetables, fruit, and fiber".


And, "Evidence that diet has an effect on the incidence of CRC is only moderate and might be affected by the multifactorial nature of CRC. Making appropriate choices across food groups, particularly with respect to fruit, vegetables, and fiber, is the key to healthy eating".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound that processes chemopreventive activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition the growth of human colon cancer.

Application of the mixed product showed a significant effect on inhibiting the growth of mouse CT-26 colon cancer xenografts from a patient's tumor that was implanted into syngenic BALB/c mice, without causing obvious side effects.

Furthermore, BN999 induced apoptosis in colon cancer cells without affecting the healthy cells.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".
Taken altogether, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Diet and colorectal cancer. Review of the evidence by Milly Ryan-Harshman, Ph.D. RD and Walid Aldoori, MB BCh MPA ScD. (PMC)