Herbal Elecampane (Inula helenium), Exerts Cytotoxic Effect on Cancer

Genotoxicity is the term associated with chemical agents that damages the genetic information within a cell, causing mutations of cell DNA, a major cause of cancer.

Not all genotoxicity is mutagenicity, However, all mutagens are genotoxic.
Cytotoxicity is the process that induces cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.

In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and prevent them from proliferation.

However, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

Stimulation of overexpression of free radicals and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

Some researchers suggested that some plant pigment, including herbal medicine lipophilic secondary metabolites, process antioxidant properties in protecting healthy cells against cytotoxicity but also stimulating the expression of free radical cytotoxicity against cancer cells.

On finding a natural ingredient of the prevention and treatment of cancers, scientists examined the polyphenol fraction (IvE) isolated from Elecampane cytotoxic activities.
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.


The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* Overall, forty-three secondary metabolites were identified, including the main components caffeic acid and unusual dihydro benzofuran lignans and cinchonain-type phenols, and hydroxycinnamoyl flavonol glycosides.

* The polyphenol fraction (IvE) showed strong antioxidant activity.

* Furthermore, the fraction inhibits cell viability and mitochondrial redox activity of neuroblastoma, hepatoblastoma, and colon carcinoma cells.

* Most importantly, IvE-induced increase of intracellular reactive oxygen species (ROS) to induce apoptosis without harming the healthy cells.

In other words, all phytochemicals found in the fraction work synergistically to exert cytotoxic and antioxidant activities against cancer cells.

Based on the results, researchers suggest, "The obtained results highlighted that inula leaves, nowadays even undervalued and unexplored, could be considered a renewable source of nutraceutical compounds.".

Taken altogether, Elecampane may be considered a remedy for the treatment of various types of cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities by Brahmi-Chendouh N1, Piccolella S2, Crescente G2, Pacifico F2, Boulekbache L3, Hamri-Zeghichi S3, Akkal S4, Madani K3, Pacifico S. (PubMed)