Herbal Angelica, Processes Anti-inflammatory Potency in Vitro

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nervous system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage.

However, people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Diseases associated with chronic inflammation asthma are chronic peptic ulcer, tuberculosis, rheumatoid arthritis, and periodontitis.

On finding a natural ingredient for the prevention and treatment of diseases associated with chronic inflammation, scientists compared the anti-inflammatory activity of Chinese herbal extracts, Drynaria baronii (DB), Angelica sinensis (AS), and Cornus officinalis Sieb. et Zucc(CO).


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the tested analysis,
* DB, AS and CO inhibited nitric oxide (NO) production by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells by inhibition of inducible NO synthase (iNOS) expression at both protein and mRNA levels.

* Furthermore, DB, AS and CO dose-dependently scavenged the NO radical produced by NOC-7 (a nitric oxide (NO)).

* Moreover, DB and CO effectively inhibited the PGE(2) production by LPS-stimulated RAW264.7 cells, although the extent of inhibition of PGE(2) production was slightly lower than that of NO production.

* More importantly, DB, AS and CO inhibited cyclooxygenase (COX)-2 expression involved in the initiation of inflammation at both protein and mRNA levels, compared to much lesser extents as compared with that for iNOS expression

* Finally, AS only marginally inhibited the LPS-stimulated PGE(2) production


Taken altogether, Danggui may be considered an anti-inflammatory remedy for the treatment of chronic inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of three herbal extracts on NO and PGE2 production by activated mouse macrophage-like cells by Chu Q1, Hashimoto K, Satoh K, Wang Q, Sakagami H. (PubMed)