Healthy Food Broccoli Blocks the Onset of Colitis in Vivo

The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.

The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.

The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).

Conventionally, colitis caused by infection is treated by antibiotics. However, treatment of non-infection colitis is focusing on symptoms relief, supportive care, and maintaining adequate hydration and pain control.

The most common tools used for the colitis diagnosis are X-rays of the colon, testing the stool for blood and pus, sigmoidoscopy, and colonoscopy.

Types of colitis according to the Catholic University of the Sacred Heart, are including
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

Epidemiologically, people with untreated colitis may experience complications of
* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in a nationwide.

* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find natural food for the prevention and treatment of colonic diseases, researchers compared the efficacy of lightly cooked broccoli (CB) containing greatly diminished myrosinase activity, with raw broccoli (RB), in mitigating colitis in dextran sulfate sodium (DSS)-treated mice.

The study included male C57BL/6 mice that were fed for two weeks on a 10% RB, 10% CB or control diet, all based on the AIN-93M diet with a half (n = 9) of each group received drinking water, and the other half received 2.5% DSS in water for one week, starting from Day 7 of the diet.
According to the tested analysis,
* CB lessened the damage by DSS, evidenced by decreased disease activity index comparable to those of RB.

* CB attenuated colon length shrinkage and lowered the endotoxin (lipopolysaccharide) leakage into the blood.

* CB also inhibited the severe colon lesions as assessed by histopathology.


* CB also decreased the mRNA expression of pro-inflammatory cytokines through broccoli anti-inflammatory action by inhibiting the IL-6 trans-signaling pathway.

In other words, CB protected the integrity of the colon cells against the onset of colitis.

Taken altogether, broccoli may be considered functional food for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lightly Cooked Broccoli Is as Effective as Raw Broccoli in Mitigating Dextran Sulfate Sodium-Induced Colitis in Mice by Wang Y1, Jeffery EH2, Miller MJ3, Wallig MA4, Wu Y. (PubMed)