Rapeseed Protein, the Promising Remedy for the Treatment of Liver Fibrosis

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.


Liver fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the liver. In other words, hepatic fibrosis is a portion of the liver which was affected by scars formation.

The exact causes of liver fibrosis are unknown. However, certain risk factors such as repeated liver injury caused by a virus infection, and a blockage in the bile ducts are found to elaborate on the onset of liver fibrosis.

Long-term untreated liver fibrosis can lead to cirrhosis, a condition of the severe scarring of the liver and life-threatening liver disease, including liver cancer.

The most common scale to grade the stage of liver fibrosis is the METAVIR scoring system. By examing the grade and stage of liver fibrosis of patients, their doctors can now determine the degree of severity to which patients' liver is affected.

The severity of the grades range from A0 to A3:
A0: no activity
A1: mild activity
A2: moderate activity
A3: severe activity

The severity of fibrosis stages range from F0 to F4:
F0: no fibrosis
F1: portal fibrosis without septa
F2: portal fibrosis with few septa
F3: numerous septa without cirrhosis
F4: cirrhosis, the most severe stage of fibrosis

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of the potential crucial pathways involved in ameliorating liver fibrosis of the rapeseed protein-derived peptide DHNNPQIR (RAP-8).

According to the analysis of the fibrotic and RAP-8 treated mice by measuring cell cycle and oxidative stress in LX-2 cells and liver samples,

* RAP-8 treated mice showed a change of modules that were mainly enriched in cell division, nuclear division, and mitotic cell cycle process by alternating the Kyoto Encyclopedia of Genes and Genomes associated with enriched in the cell cycle.

* More precisely, the regulations of three core genes (Cenpp, Cyp2c55, Serpinh1) by RAP-8 were verified to target for treating liver fibrosis.

* RAP-8 induced cell cycle arrest and prevents oxidation stress in the induction of liver fibrosis.

Based on the results, researchers wrote, " As a promising therapeutic candidate for hepatic fibrosis treating, RAP-8 exhibited anti-fibrotic effects via exerting cell cycle arrest and inhibiting oxidative stress."

And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".

In other words, SFN protected the integrity of the neurons against neuron damage through it's anti-neuroinflammatory and neuroprotective activities.

Taken altogether, rapeseed protein may be considered supplements for the prevention and treatment of liver fibrosis, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress by Xu H1, Hong S1, Yan Z2, Zhao Q1, Shi Y2, Song N1, Xie J2, Jiang X. (PubMed)