Coffee and Coffee Caffeine In Reduced Risk Of Thyroid Cancer?

Epidemiological studies, linking coffee and coffee caffeine intake in the prevalence of thyroid cancer incidence have been contradictory and inconclusive.

Thyroid cancer is a chronic condition of irregular cell growth in the thyroid gland.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of database from Published studies in PubMed, Embase, Cochrane Central, and the reference lists of the retrieved articles to evaluate the association between coffee consumption and the risk of thyroid cancer, researchers at the joint study lead by the Chosun University, filed the following results.
1. In a total of 1039 thyroid cancer cases and 220,816 controls were identified from five case-control studies and two cohort studies, the relative risk ratio of cancer incidence was 0.88 in compared to baseline.
2. Risk of thyroid cancer was reduced significantly only in hospital-based case-control studies.


Dr. Han MA, the head researcher said, "There was no significant association between coffee consumption and thyroid cancer risk according to our meta-analysis results" and "There was no significant heterogeneity among the study results".

Other, in the analyzed data from a prospective cohort (100,507 persons (48,802 men; 51,705 women) aged 40-69) between green tea and coffee consumption and risk of thyroid cancer, assessed via a self-administered questionnaire, researchers at the National Cancer Center found no association between coffee intake and risk of thyroid cancer regardless to gender and amount of coffee intake per day.

Furthermore, in the pool sample consisted of 2725 thyroid cancer cases (2247 females, 478 males) and 4776 controls (3699 females, 1077 males), through intensive analysis of 14 case-control studies conducted in the United States, Europe, and Asia suggested that risk of thyroid cancer is not associated with coffee consumption, independent to gender difference.


The study also emphasized that even taking into account other factors, caffeinated beverages did not alter thyroid cancer risk.

Contrastively, according to Aretaieion University Hospital, in a case-control, serially matched study containing 70 patients with thyroid cancer, 55 with benign thyroid disease and 71 controls, there were significantly reduced risk of thyroid disease among coffee and coffee caffeine drinkers. Even after adjustment for possible confounding variables, the association remained statistically significant

Dr. Linos A, the lead author said, " The mechanism by which coffee consumption may play a protective role against the development of benign or malignant thyroid neoplasms may be the stimulatory effect of caffeine on the intracellular cyclic AMP production, which is known to inhibit cell growth".

Taking all together, the contradicting results may warrant a large sample size and cohost studies before researchers can make a decision between coffee and coffee caffeine intake and risk of thyroid cancer.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis by Han MA1, Kim JH2.(PubMed)
(2) Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan by Michikawa T1, Inoue M, Shimazu T, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S.(PubMed)
(3) A pooled analysis of case-control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea by Mack WJ1, Preston-Martin S, Dal Maso L, Galanti R, Xiang M, Franceschi S, Hallquist A, Jin F, Kolonel L, La Vecchia C, Levi F, Linos A, Lund E, McTiernan A, Mabuchi K, Negri E, Wingren G, Ron E.(PubMed)
(4) Does coffee consumption protect against thyroid disease? by Linos A1, Linos DA, Vgotza N, Souvatzoglou A, Koutras DA.(PubMed)