Coffee, A functional Food for Prevention of Hepatic Cirrhosis

Intake of coffee daily and regularly may have a profound and therapeutic effect in reduced risk and treatment of Hepatic Cirrhosis

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Hepatic Cirrhosis is a condition characterized by the abnormal function of the liver due to the presence of live damage or scarring.

In the experiments in cellular and animal models provided biological plausibility, coffee consumption exhibited liver protective effect in prevent the Cirrhosis from developing through it's as an antifibrotic activity.

According to the Arauz and colleagues study in the exam, one of the key questions regarding the antifibrotic role of coffee, coffee as a specifically primary antifibrotic agent is considered as a functional food in prevent and treatment of chronic liver disease.

Dr. Dranoff J in the analysis Coffee Consumption and Risk of Cirrhosis suggested that coffee consumption is inversely related to the progression of liver fibrosis to cirrhosis and even hepatocellular carcinoma.

Furthermore, in the study to evaluate the hepatoprotective properties of coffee and caffeine in a model of chronic bile duct ligation (BDL) in male Wistar rats with liver injury induced by 28-day BDL, assigned to administered group of conventional coffee, decaffeinated coffee, or caffeine daily, researchers at the lead Autonomous University of Baja California, filed the following results

1. Intake of coffee showed significant effects in promoted antioxidant status by restoring the redox equilibrium, preventing the elevation of liver enzymes as well as hepatic glycogen depletion.
2. Coffee and caffeine consumption prevented collagen increases
3. Coffee intake reduced protein in expression in promoting hepatic infectious cell activation,
4. Coffee intake decreased expression levels of transforming growth factor-β, connective tissue growth factor, α-smooth muscle actin, and collagen in inducing further damage in a tested model of chronic bile duct ligation (BDL).


The result indicated that coffee intake have a strong efficacy in prevent liver cirrhosis developing through antioxidant activity, hepaprotective effect, reduced profibrotic molecules anti proinflammation involved expression of Cirrhosis.


More interestingly, in the comparison of total 195 patients with end-stage liver disease (ESLD) consumed coffee on a daily basis and 184 patients did not. researchers at the joint study lead by the University Hospital of Heidelberg found that coffee consumption, in fact, ameliorated the progression of liver cirrhosis and increased long-term survival after liver transplantation in compared to nondrinker.



With all the information found, one may be considered coffee as a functional food in attenuated risk and treatment of liver cirrhosis through its liver protective effect via phytochemicals in demonstration of antioxidant expression.



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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Consumption and Prevention of Cirrhosis - In Support of the Caffeine Hypothesis by Dranoff J1.(PubMed)
(2) Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans by Arauz J1, Zarco N2, Hernández-Aquino E3, Galicia-Moreno M1, Favari L3, Segovia J2, Muriel P4.(PubMed)