Coffee and Coffee Caffeine in Attenuated Risk of Liver Fibrosis

Coffee intake daily and regularly may have a potential impact in reduced risk of hepatic fibrosis during recovery of liver injured, a renowned institute study suggested.

Coffee, second to tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Hepatic fibrosis is profusely and abnormally recovery of wound healing, causing excessive connective tissues to build up in the liver.


In an experiment model of induced Liver injury by 28-day of chronic bile duct ligation (BDL) in male Wistar rats with conventional coffee, decaffeinated coffee, or caffeine administered daily, researchers at the joint study reported the following results
1. In compared to conventional coffee, caffeine expressed a significant suppression of most of the changes produced by BDL, particularly in antifibrotic effects
2. All types of coffee displays elevated antioxidant properties in restored redox equilibrium, thus preventing the elevation of liver enzymes and hepatic glycogen depletion
3. Caffeinated coffee and caffeine exhibited a reduced in increased collagen

In fact, the efficacy of coffee and caffeine in the ameliorated risk of liver fibrosis may be attributed to phytochemical compounds in increased antioxidant status and decreased overexpression of pro-inflammatory cytokines as well as regulating protein in overproduction of collagen.

Other, in support of the above analysis, researchers in the study to evaluate the antifibrotic properties of coffee in male Wistar rats with liver damage induced by repeated administration of thioacetamide (TAA). Oral administration of conventional caffeinated coffee or decaffeinated coffee (CC, DC, respectively) for 8 weeks reported the following results
1. Intake of coffee showed a significant effect in the suppression of most of the damage produced by TAA in rat liver
2. Coffee reduced expression of ongoing experimental cirrhosis by blocking the elevation of the profibrogenic cytokine TGF-β and its downstream effector CTGF in the induction of inflammation through increased antioxidant status, regardless to types of coffee and numbers of cup intake per day.


Dr. Arauz J, the lead researcher said, " Various components of coffee that have been related to such a favorable effect(in reduced risk of hepatic fibrosis) include caffeine, coffee oils kahweol, cafestol, and antioxidant substances".

Interestingly, the Biophysics and Neuroscience Infectomics and Molecular Pathogenesis study also reconfirmed that effect of coffee and coffee caffeine in the attenuated risk of liver fibrosis resulted from the following demonstrations
1. Caffeine prevents elevation of liver enzymes in reduced liver tissues damage and overexpression of collagen in the rats treated with TAA plus.
2. Caffeine elevated antioxidant properties by restoring the redox equilibrium through reduced lipid peroxidation and glutathione peroxidase (GPx) levels
3. Reduced proinflammatory initiation.


Taking all together, coffee and coffee caffeine regardless of numbers of cup intake per day illustrated a significant effect in ameliorated risk and progression of hepatic fibrosis.



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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(2) Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans by Arauz J1, Zarco N2, Hernández-Aquino E3, Galicia-Moreno M1, Favari L3, Segovia J2, Muriel P4.(PubMed)
(2) Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage by Arauz J1, Moreno MG, Cortés-Reynosa P, Salazar EP, Muriel P.(PubMed)
(3) Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β by Arauz J1, Zarco N, Segovia J, Shibayama M, Tsutsumi V, Muriel P.(PubMed)