Coffee and Coffee Caffeine In Attenuated Risk and Symptoms of Hepatic Steatosis

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Hepatic steatosis. a fatty liver disease caused by excessively accumulated amounts of triglycerides and other fats inside liver cells due to several factors alcoholism, malnutrition, pregnancy, or drug therapy.


In the analyzed 1024 Japanese male workers in diagnosed of hepatic steatosis based on ultrasonography, participants divided coffee and green tea consumption into the following three categories: non-drinker; 1-2 cups/day and ⩾3 cups/day, after adjusting to other risk factors, researchers filed the following results
1. Out of 1024 patients, 25.9% were diagnosed with hepatic steatosis.
2. Patients drinking >3 cups of coffee/day displayed a significantly lower risk of hepatic steatosis in compared to noncoffee drinker group.
3. Coffee intake reduced expression of leptin, a protein produced by fatty tissue and believed to regulate fat storage in the body of moderate-severe hepatic steatosis groups.

Base on these results, researchers of the joint study lead by the Fukuoka University, insisted that coffee and coffee caffeine not only reduced risk of prevalence of hepatic steatosis but also improved liver function through a decreased level of leptin in fat accumulation.

More importantly, in the study of aged C57 BL/6 NCr mice divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0.1% decaffeinated coffee (n = 9) for 17 wk until mice reached the age of 24 months, researcher files the following reports
1. Regular and decaffeinated coffee consumption display a decreased plasma-free fatty acid levels and increased hepatic adenosine triphosphate content, an indication of reduced risk of hepatic steatosis
2. Coffee and coffee caffeine also reduced expression of protein content, responsible for fat accumulation in the liver.
3. Coffee consumption in these aged population demonstrated a positive effect on behavioral energy and lipid metabolism as well.

More interestingly, Dr. Salomone F, the lead researcher at the joint study lead by the Azienda Sanitaria Provinciale di Catania, in the investigated coffee phytochemicals effect in reduced risk of liver diseases said, "in experimental models of fibrosis, caffeine was shown to inhibit hepatic stellate cell activation by blocking adenosine receptors, and emerging evidence indicated that caffeine may also favorably impact angiogenesis and hepatic hemodynamics" and " chlorogenic acids, potent phenolic antioxidants, suppress liver fibrogenesis and carcinogenesis by reducing oxidative stress and counteract steatogenesis through the modulation of glucose and lipid homeostasis in the liver".

Taking together, there is no doubt that coffee and coffee caffeine would have a significant and therapeutic effect in attenuated risk and complication of hepatic steatosis, through expression in reduced fat accumulation and lipid peroxidation in the liver.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee but not green tea consumption is associated with prevalence and severity of hepatic steatosis: the impact on leptin level by Imatoh T1, Kamimura S2, Miyazaki M3.(PubMed)
(2) Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels byTakahashi K1, Yanai S2, Shimokado K3, Ishigami A4.(PubMed)