Cucumber, the Potential Anti Cancer Whole Food

Cancer is a class of diseases associated with irregular cell growth caused by the alternation of cell DNA.

Most common types of cancer in Canada are non-melanoma skin cancer, lung, breast, colorectal and prostate cancer.

Most cases of primary cancer begin in the cells on the surface of the inner lining of the tissues of a specific organ.

At the early stage, due to the small size of the tumor, most patients with cancer are asymptomatic. However, at the advanced stage, all cancers not only share the general symptoms of gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue, they also induce specific symptoms, such as bleeding and severe pain, depending on the location of the tumor.

At this stage, most cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Conventionally, cancer at the localized stage is normally treated with surgery to remove the tumor and radiotherapy to kill off the remaining cancer cells. However, if cancer has spread, a combination of surgery, radiotherapy, and chemotherapy may be necessary.

There are a number of prevalent factors that have been found to increase the risk of cancer. Some researchers suggested the rise of cancer in older adults probably is associated with increased life expectancy over the past few decades.

Dr. Anisimov VN, the scientist at the cancer team at the N.N. Petrov Research Institute of Oncology said, "A significant increase in the number of old people in the populations of developed countries was followed by an increase in morbidity and mortality resulting from main age-related diseases -- cardiovascular, cancer, neurodegenerative, diabetes mellitus, a decrease in resistance to infections".

And, " There was a high positive correlation between the type of geroprotector-induced aging delay and the pattern of tumor development in the same population of animals. The first type of geroprotectors did not influence the incidence of the tumor but increased tumor latency".


The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a potential anti-cancer natural compound with no side effect, researchers examined the cellular function of Pediococcus pentosaceus CRAG3 (GenBank ID: JX679020), a novel isolated from the fermented cucumber.
In vitro,. according to the cytotoxicity analysis, the dextran novel dextran from Pediococcus pentosaceus CRAG3 exerted cytotoxic effects against cervical cancer (HeLa) and colon cancer (HT29) cell lines.


According to the additional differentiation, the efficacy of dextran anticancer activity was attributed to its function in enhancing the growth of macrophage from the immune system.

In heat shock protein Hsp90, indirectly induced multiple pathways that lead to angiogenesis and metastasis in cancer, researchers examined the Vitexin from the Cucurbitaceae family in the restraining angiogenesis activity of this protein.

According to the docking results, Vitexin, a prominent glycosylated natural flavonoid, showed a promising inhibitory potential against Hsp90.

In other words, Vitexin protected the cell integrity against the alternation of cell DNA induced heat shock protein Hsp90.

Dr. Sharma N, the lead scientist after taking other factors into account wrote, "Vitexin to hold prominent antiangiogenic potential surpassing different in silico parameters and thus expected to be a multi-targeted novel antiangiogenic lead".

Taken altogether, cucumber may be considered supplements for the prevention and treatment of cancer pending to the confirmation of the larger sample size and multicenter human study.

Intake of Vitexin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Novel dextran from Pediococcus pentosaceus CRAG3 isolated from fermented cucumber with anti-cancer properties by Shukla R1, Goyal A. (PubMed)
(2) Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativusTargeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena by Sharma N1, Akhtar S2, Jamal QMS3, Kamal MA4, Khan MKA5, Siddiqui MH5, Sayeed U1. (PubMed)
(3) Life span extension and cancer risk: myths and reality by Anisimov VN. (PubMed)