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Wednesday, May 18, 2016

All About #CurableVitamins: The effect of Vitamin B6 on Endometrial Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamins are organic compounds and vital nutrients needed by your body to grow and develop in a profound way.

Vitamin B6
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

    The Effect of Vitamin B6 on Endometrial Cancer

The incidence of endometrial cancer among white women are higher in comparison of black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Epidemiological studies linking vitamin B6 in reduced risk of endometrial cancer have been inconclusive, but the composition of vitamin B6 and other micro nutrient have found to be effective in some studies. One-carbon metabolism in 26 years of follow-up data from the Nurses' Health Study, do not appear to influenceendometrial cancer incidence but showed protective effect for women with MTHFR 677 TT or MTHFR 1298 CC genotype(1) and a case of case-control study in Greece, indicated that intkae of Retinol, nicotinic acid, vitamin B- 6, and riboflavin were inversely associated with the disease(2).
But in a study between 1997 and 2003, 1,204 newly diagnosed endometrial cancercases and 1,212 controls recruited among women between the ages of 30 and 69 years in urban Shanghai, China, showed dietary intake of vitamin B6 was not related to risk of endometrial cancer for women with enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), encoded by the MTHFR gene(3). Due to small size of some studies, some researchers suggested that large example size and multi centers studies are necessary to validate the effectiveness of any micro nutrient in endometrial cancer risk.

Taking altogether, without going into reviews, the composition of vitamin B6 and other micro nutrients may be effective in reduced risk and treatment of endometrial cancer. Over doses may induced the symptoms of difficulty coordinating movement, numbness, sensory changes, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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(1) One-carbon metabolism factors and endometrial cancer risk by Liu JJ1, Hazra A, Giovannucci E, Hankinson SE, Rosner B, De Vivo I.(PubMed)
(2)Diet in relation to endometrial cancer risk: a case-control study in Greece by Petridou E1, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D.(PubMed)

(2) Dietary folate intake, MTHFR genetic polymorphisms, and the risk ofendometrial cancer among Chinese women by Xu WH1, Shrubsole MJ, Xiang YB, Cai Q, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)

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