Bromelain, a Natural Prevention and Treatment of Chronic Constipation

Constipation is a condition of hard and dry stool that is infrequent or hard to pass.

Acute constipation caused by staying in a sitting position for long periods of time that kinks up the colon and restrain stool from passing through can be reversed in a few days with or without the use of
a laxative or over the counter medicine

Chronic constipation is a condition characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements with less than 3 bowel movements a week.

In most cases, chronic constipation with no structural and medical problems is normally caused by long-term an unhealthy diet with low fiber.

Certain medications calcium channel blockers, narcotics are also found to induce constipation.

According to the recommendation of the health professionals, total fiber intake per day is 25-35 grams, depending on your sex, age, and weight for people with or without the condition of constipation.

Some people taking total fiber intake per day is 25-35 grams may experience symptoms of excess colon gas and flatus. In this instance, soluble fiber should be cut down on first before cutting down of insoluble fiber.

More precisely, a high fiber diet must be accompanied by increased fluid intake and moderate exercise for maintaining good colon health against constipation in patients with no structural and medical problems.

According to the statistics, in the US, approximately 4 million people have frequent constipation, affecting about 2 percent of Americans. Constipation also is the most common digestive complaint in the US, outnumbering all other chronic digestive conditions.

Some researchers suggested that there is a correlation between aging in the risk of constipation.

Dr. Brenda G. Schuster wrote, "Constipation is a common complaint and challenge for older adults. The prevalence of constipation increases with age and differs among settings. In individuals 65 years of age or older in the community, the prevalence is 26% for women and 16% for men.1

And "This rate increases to 34% for women and 26% for men in those 84 years of age and older.1For long-term care residents, the prevalence is as high as 80%".

In other words, adults who are 65 years of age are at a higher risk of constipation.


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a natural laxative compound for the treatment of chronic constipation, researchers examined the effect of bromelain (EC 3.4.22.33) isolated and purified from pineapple fruit on constipation.

In rat constipation induced gavage administration of loperamide hydrochloride treated by bromelain, showed significant relief of the high visceral sensitivity and infrequent stools in constipated rats.

Furthermore, bromelain treated rats also reversed the slow gastric emptying and intestinal transit.


Moreover, bromelain relieved constipation in tested rats by stimulating intestinal contraction.

The efficacy of anti-constipation of bromelain was attributed to significantly reverse the decrease of phosphorylation of the 20 kDa regulatory light chain of myosin (p-MLC20) associated with cellular functions such as muscle contraction, mitosis, and cytokinesis. and the expression of MLCK associated with gastro emptying and intestinal transit in constipation-predominant.

In other words, bromelain efficacy on constipation is to promote mechanisms involved in increased gut motility.

Based on the findings, researchers said, "The beneficial effect of pineapple on constipation is partly dependent on fruit bromelain although the fibers and fluid in pineapple juice are also beneficial".

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of chronic constipation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fruit bromelain ameliorates rat constipation induced by loperamide by Zijuan Zhou‡ a, Liang Wang‡a, Ming Xu‡b, Lianhong Yin, Fang Yang, Simei Huic, Yanlin Yi, Panpan Fenga, Jingyu Wanga, Yuan Lin*b, Jinyong Peng and Dapeng Chen. (the Royal Society of Chemistry)
(3) Constipation in older adults. A stepwise approach to keep things moving by Brenda G. Schuster, Lynette Kosar, and Rejina Kamrul (PMC)