Herbal Ashwagandha Arrests Prostate Cancer In Vitro

Cancer is a group of chronic diseases caused by irregular cell growth in the specific tissue of an organ due to DNA alternation.

Most cases of cancer start in the cell of the surface of the inner lining tissue before penetrating into deeper layers to form a tumor.

However, as cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction, blood in the urine and blood in the seminal fluid.

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some prevalent factors found in patients with the condition.

Conventionally, treatments of prostate cancer are totally depending on the type, stage, and grade accompanied by the patient overall health, age and life expectancy.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Researchers on finding a potent and natural ingredient for the treatment of prostate cancer investigated the effects of Withania extracts on highly metastatic, androgen-independent prostate cancer cell line (PC3).


According to the results obtained from tested differentiation, the extracts demonstrated strong inhibitory activity in decreasing the cancer cell viability with a half-maximal inhibitory concentration (IC50) of 10 μg/mL.

The sample of prostate tissue and in PC3 cells also exhibited the predominantly high expression levels of IL-8 associated with the production chemokine produced by macrophages and COX-2 involved in the contribution of immune evasion and resistance to cancer immunotherapy were also suppressed by the lowest dose of W. somnifera in 24 hours.


Furthermore, the extract induced cycle arrest of the cancer cell line at the cell cycle in G2/M phase, observed from the rapid accumulation of PC3 cells significantly.

Moreover, W. somnifera extracts suppressed the PC3 inherent metastatic activity.

Based on the results, researchers wrote, "W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of prostate cancer, pending to the confirmation of larger size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells by Rehman S1, Keefover-Ring K2, Haq IU3, Dilshad E4, Khan MI5, Akhtar N6, Mirza B. (PubMed)
(2) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Setty Balakrishnan A1, Nathan AA1, Kumar M1, Ramamoorthy S2, Ramia Mothilal SK. (PubMed)