Cardiac toxicity is a condition in which the heart has been damage to some extent caused by harmful chemicals, including toxins induced by the treatment of chemotherapy.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Conventionally, treatment of cardiac toxicity includes medication to control fluids, high blood pressure, and medications which improve heart functioning. If all aforementioned medications fail, a heart transplant may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cardiac toxicity scientists launched an investigation to determine whether curry intake reduces blood levels of heavy metals, according to the Korean National Health and Nutrition Examination Survey 2013 data.
1,350 participants selected to the study were randomly divided into either curry intake group with the consumption of a curry dish more than once a month over the previous year, or a non-curry intake group (n = 747).
According to the heavy metal analysis, the curry intake group showed significantly lower heavy metal blood concentrations (Pb, Hg, and Cd).
Furthermore, the levels of heavy metals in patients with hypertension (HTN) were significantly lower in the curry intake group compared to the nonhypertension group.
The levels of blood concentrations of heavy metals induced toxicity associated with the induction of hypertension were significantly lower compared to the placebo.
The results confirmed the correlation between blood heavy metal levels and HTN.
In other words, turmeric has a potential effect on reducing cardiac toxicity in the induction of abnormally blood pressure.
In order to obtain turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorate the effect of DOX-induced cardiac toxicity.
Additionally, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, associated with the increased risk of cardiovascular disease.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac,.....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of cardiac toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean by Choi JW1, Oh C2, Shim SY1,3, Jeong S4, Kim HS5, Kim MS. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
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