Coffee Intake May Increase the Risk of Bladder Cancer

Coffee consumption may have a linear association with the potential risk of bladder cancer development,
a respectable institute postulated.

Bladder cancer is a medical condition of cell growth irregularly and disorderly in the bladder. Cancer may spread to distant tissues and organs in the later stage.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to Shandong University, in the review literature published online satisfied the criteria and guidelines to investigate the risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01

The findings in both case-control and cohort studies showed a positive association of coffee intake and risk of bladder cancer.



In nonsmokers, according to the pooled data set comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy, and Spain. risk of bladder cancer did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per day, the risk bladder cancer increases substantially.

Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".


Other, in analyzed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to nondrinkers (RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1.RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more



Taking together, there is no doubt that coffee and coffee caffeine consumption have a significant risk in the exhibited incidence of bladder cancer regardless of the numbers of cup intake daily and regularly.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)