Phytochemical Allyl isothiocyanate and Bladder Cancer

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it effects women. Usually, it starts from the lining of the bladder caused by several types of malignant growths of the urinary bladder cells.


The study of AITC found cruciferous vegetables and celecoxib effects in modulating cyclooxygenase-2 (Cox-2), as its oncogenic activity has been well documented in bladder cancer and other cancers, this effectiveness is as result of associated with depletion of prostaglandin E2, a key downstream signaling molecule of Cox-2, caspase activation and downregulation of vascular endothelial growth factor in the tumor tissues.

In another study, the N-acetylcysteine conjugate (NAC-AITC) is found to be a significant inhibition of cell growth and proliferation in human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM.


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References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)