Herbal Ashwagandha Inhibits the Onset of Breast Cancer Patients

The breast formed part of the reproductive system consists of tissue overlying the chest (pectoral) muscles. In women, the breasts are made of produces milk (glandular tissue) and fatty tissue.

The size of the women's breast is totally depending on the amount of breast fatty tissue.

Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.

In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.

Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.

According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.

The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of BRCA 1 and 2 are some of the most prevalent factors associated with the disease.

Women inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.


Some researchers suggested the promotion of a high-fat diet-induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.

Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".

And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".

These results strongly suggested the long-term high fat diet is associated with the increased risk of breast cancer.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti side effects of chemo drug.

The open-label prospective nonrandomized comparative trial included a total of on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.

Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.

According to the results, patients in the control arm or chemotherapy only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.

Statistically, 7 out of 18 symptoms in the intervention group was significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.


More importantly, The 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.

However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.

Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)