Indicaxanthin Processes Redox Status Property

The redox status refers to the balance between the levels of free radicals and other reactive species and antioxidants.

Oxidants or ROS species can be produced by the body cell metabolism or from the external sources such as the air we breathe and the foods we eat.


Free radicals in moderate amounts are necessary for the body functioning, inclduing NO for vascular relaxation.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.


Antioxidants are stable molecules that play a critic role to protect our body against oxidation.

There are 2 types of antioxidants, antioxidants produced by the host are called antioxidant enzymes and antioxidant came from dietary intake.

Under normal conditions, antioxidants produced by the host are good enough to keep the levels of free radicals in check.

Imbalanced levels of free radicals and antioxidants induced oxidative stress, a major cause of many chronic ailments. In other words, free radicals overexpression caused by chain oxidative reaction that induces oxidative stress causes protein, lipid, and DNA, leading to chronic disease including cardiovascular disease, diabetes, and cancer.

According to Dr. Parvin Mirmiran, and colleagues in the joint study led by the Beheshti University of Medical Sciences, on oxidative stress in patients with metabolic syndrome, wrote, "(By) following a healthy pattern filled with fruits and vegetables ameliorates oxidative stress status and on the contrary, attachment to an unhealthy pattern, characterized by higher intakes of fast foods and processed foods, aggravated the oxidative stress levels in Tehranian individuals suffering from metabolic syndrome".
Therefore, by enhancing antioxidant status in the body through regular physical activity and intake of fruits and vegetables which contain a high amount of dietary antioxidants to offset the free-radical toxic effects, the risk of oxidative stress can be reduced substantially.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound that processes chemo-activity, researchers examined the effect of Indicaxanthin as a natural chemoactive and chemopreventive agent.

The randomized, double-blind, placebo-controlled and crossover design included 8 women (23.25±2.95 years old, weight of 54.13±9.05 kg, height of 157.75±0.66 cm and BMI of 21.69±0.66 kg/m2) randomly divided into 2 groups and each group was supplied with either 50 ml OFI, diluted to 170 ml with water, or 170 ml Placebo containing the same concentration of fruit juice ingredients except for Vitamin C and indicaxanthin.


According to the blood samples from women taken before and after the effort test without supplementation (baseline), pre- and post-test, 24 h and 48 h post-test with OFI or Placebo supplementation every day for 3 days before of effort test on a cycle ergometer and continued to take it for 2 consecutive days after testing, free radical H2O2 levels were significantly decreased and total antioxidant capacity (PAT) significantly increase in the OFI group comapred to placebo.

In other words, by comparing the effect on OFI and placebo groups, the antioxidants vitamin C and indicaxanthin may be the major constituents in the induction of the efficacy of OFI in restoring redox balance.

Based on the results, researchers said, " OFI supplementation might be used to restore redox balance after intense exercises in moderately trained women".


Taken altogether, indicaxanthin may be considered a remedy in restoring redox balance after intense exercises in moderately trained women, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plasma redox response of Sicilian Opuntia Ficus Indica juice in young physically active women by Marianna Bellafiore, Anna Maria Pintaudi, Angelo Cataldo, Dario Cerasola, Alessandro Attanzio, Giuseppe Battaglia, Antonino Bianco, Antonio Palma. (Italian Journal of Anatomy and Embryology)
(2) Effect of dietary patterns on oxidative stress in patients with metabolic syndrome: Tehran Lipid and Glucose Study by Parvin Mirmiran, Ph.D. Hoda Hadavi, MSc, Azadeh Mottaghi, Ph.D., and Fereidoun Azizi, MD. (PMC)