Phytochemical Piperine on Cognitive Impairment

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.

In chronic unpredictable stress (CUS)-induced cognitive impairment and oxidative stress in mice,
Piperine showed to potentiate the protective effects of curcumin in significantly improved behavioral and biochemical alterations, restored mitochondrial enzyme complex activities and attenuated increased acetylcholinesterase and serum corticosterone levels.

In olfactory bulbectomy induced depression in rats, co-administration of piperine with curcumin significantly potentiated the effects in behavioral, biochemical, mitochondrial, molecular and histopathological alterations. These potentiations of co-administration also showed to prevented all the behavioral, cellular, and neurochemical changes associated with the chronic administration of haloperidol, as compared to their effects alone.


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References
(1) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(2) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression.


Rinwa P, Kumar A, Garg S.(PubMed)
(3) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)