Fungi are a kind of living organism, including molds, molds, and mushrooms.
Most cases of fungal infections start in the lungs or on the skin. People with a weakened immune system or long-term use of antibiotics and immune-suppressive medicine are prone to getting a fungal infection.
Histoplasmosis, which is the most common fungal infection in the US, caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.
However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis were diagnosed in the US each year.
Believe it or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.
Most cases of fungal infection are treated with antibiotics topically or orally.
The untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on types of fungal infection.
Most common types of fungal infection
* Athlete's foot
Athlete's foot is a common fungal infection that affects the foot.
* Yeast infection
Yeast infections are a common form of Candida overgrowth caused by Candida albicans.
* Jock itch
Jock itch is another type of skin infection that appears mostly in summer or in warm, humid areas of the world.
* Ringworm
Ringworm is a type of skin infection caused by a fungus that lives on dead tissues,
On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the antifungal activity of the chemical composition of the eyebright essential oil.
Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.
The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.
According to the Chromatography-Mass Spectrometry (GC-MS) analysis, the eyebright essential oil containing more than 70 constituents, with n-hexadecanoic acid (18.47%) as the main constituent showed a strong anti-fungal effect against all organisms, especially in the case of anticandidal activity.
Lauric acid found in the EO exhibited the strongest activity against a number of fungi. compared to other chemical constituents.
The Minimum Inhibitory Concentration (MIC) that exerted antibiotics against the bacteria and yeast susceptible to the EO was in accordance with the Clinical Laboratory Standards Institute (CLSI) acceptable limits and previous reports, respectively.
Based on the results, researchers suggest, "the chemical analysis revealed a number of antimicrobial active substances present in the E. rostkoviana EO and its antifungal and antibacterial activity...".
Taken altogether, Eyebright may be considered a remedy for the treatment of fungal infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Composition and Antimicrobial Activity of Euphrasia rostkoviana Hayne Essential Oil by Hana Davidova,1 Cecilia Suqued Serrano-Rojero,1 Johana Rondevaldova,2 Josef Pulkrabek,3 and Ladislav Kokoska, (Hindawi)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Tuesday, March 31, 2020
Monday, March 30, 2020
Turmeric, the Best for the Prevention and Treatment of Eye Disease
The eyes are organs of sight that help us to see. The eyes also adjust to low light and darkness for good vision.
The eyes process the ability to receive and process s visual detail by detecting light and converting them into electro-chemical impulses in neurons.
Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, However, at the advanced stage, people with eye disease may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the improvement of vision health, researchers examined the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases.
In the study, curcumin structural was modified to prevent low solubility and digestive bioavailability.
The modified application showed a significant effect to protect the eye through its anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis, anterior uveitis.
Furthermore, curcumin in the new modification also demonstrated anti-proliferation and pro-apoptosis effects in pterygium; anti-oxidative stress, anti-osmotic stress, anti-lipid peroxidation, pro-apoptosis, regulating calcium homeostasis.
Additionally, sequestrating free radicals, protein modification and degradation effects in cataracts; neuroprotective effects in glaucoma were also inhibited by the new modification.
Based on the results, researchers said, "Curcumin exhibited to be a potent therapeutic candidate for treating those anterior segment eye diseases".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of eye diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Potential Therapeutic Candidate for Anterior Segment Eye Diseases: A Review by Liu XF1, Hao JL1, Xie T2, Mukhtar NJ1, Zhang W3, Malik TH4, Lu CW1, Zhou DD. (PubMed)
The eyes process the ability to receive and process s visual detail by detecting light and converting them into electro-chemical impulses in neurons.
Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, However, at the advanced stage, people with eye disease may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the improvement of vision health, researchers examined the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases.
In the study, curcumin structural was modified to prevent low solubility and digestive bioavailability.
The modified application showed a significant effect to protect the eye through its anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis, anterior uveitis.
Furthermore, curcumin in the new modification also demonstrated anti-proliferation and pro-apoptosis effects in pterygium; anti-oxidative stress, anti-osmotic stress, anti-lipid peroxidation, pro-apoptosis, regulating calcium homeostasis.
Additionally, sequestrating free radicals, protein modification and degradation effects in cataracts; neuroprotective effects in glaucoma were also inhibited by the new modification.
Based on the results, researchers said, "Curcumin exhibited to be a potent therapeutic candidate for treating those anterior segment eye diseases".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of eye diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Potential Therapeutic Candidate for Anterior Segment Eye Diseases: A Review by Liu XF1, Hao JL1, Xie T2, Mukhtar NJ1, Zhang W3, Malik TH4, Lu CW1, Zhou DD. (PubMed)
Sunday, March 29, 2020
Gamma-Linolenic Acid, A Potential Treatment of Dermatitis in Vitro
Dermatitis is condition associated skin irritation that involves itchy, dry skin or a rash on swollen, reddened skin.
Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.
Many chemicals and nonchemicals substances have been found to induce abnormal reactions, including cosmetics, fragrances, jewelry, and plants.
Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.
Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.
Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning or tenderness skin.
Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.
Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.
The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environment conditions may be involved in the development of the disease.
Conventionally, dermatitis is treated by
* Steroid creams or ointments for soothing the rash.
* Oral medications such as oral corticosteroids for reducing inflammation, antihistamines to relieve itching or antibiotics to fight a bacterial infection.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-skin disease activity, researchers examined the effect of Dihomo-γ-linolenic acid (DGLA, C20: 3n-6), an anti-inflammatory agent on dermatitis.
According to the results of the analysis of yeast Saccharomyces cerevisiae strain as a DGLA synthesis
* Oral intake of this yeast significantly suppressed inflammatory reactions, compared to no such suppression that was observed by the intake of 25 times the amount of purified DGLA.
* Yeast Saccharomyces cerevisiae strain as a DGLA synthesis was considered to be a simple and efficient way to suppress inflammation.
* Furthermore, the synthesis compound also was effective against allergic contact dermatitis (ACD).
Taken altogether, -γ-linolenic acid may be considered a remedy for the prevention and treatment of dermatitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice by Watanabe N1, Teradu S1, Ohtani M1, Uemura H. (PubMed)
Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.
Many chemicals and nonchemicals substances have been found to induce abnormal reactions, including cosmetics, fragrances, jewelry, and plants.
Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.
Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.
Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning or tenderness skin.
Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.
Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.
The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environment conditions may be involved in the development of the disease.
Conventionally, dermatitis is treated by
* Steroid creams or ointments for soothing the rash.
* Oral medications such as oral corticosteroids for reducing inflammation, antihistamines to relieve itching or antibiotics to fight a bacterial infection.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-skin disease activity, researchers examined the effect of Dihomo-γ-linolenic acid (DGLA, C20: 3n-6), an anti-inflammatory agent on dermatitis.
According to the results of the analysis of yeast Saccharomyces cerevisiae strain as a DGLA synthesis
* Oral intake of this yeast significantly suppressed inflammatory reactions, compared to no such suppression that was observed by the intake of 25 times the amount of purified DGLA.
* Yeast Saccharomyces cerevisiae strain as a DGLA synthesis was considered to be a simple and efficient way to suppress inflammation.
* Furthermore, the synthesis compound also was effective against allergic contact dermatitis (ACD).
Taken altogether, -γ-linolenic acid may be considered a remedy for the prevention and treatment of dermatitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice by Watanabe N1, Teradu S1, Ohtani M1, Uemura H. (PubMed)
Saturday, March 28, 2020
Antioxidant Lycopene Protects the Lung Against Pulmonary Fibrosis (PF)
Pulmonary diseases are a class of conditions associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The lung formed part of the respiratory system with a function of the primary organs of the respiratory system to absorb oxygen to the blood and shall carbon dioxide from the blood.
Pulmonary fibrosis (PF) is a condition associated with the formation of scars in the lungs. Over time, overexpression of scar tissue can destroy lung and interfere with the lung to take oxygen to the blood.
According to the American Lung Association, the most common PF is idiopathic pulmonary fibrosis. Approximately 50,000 new cases of IPF are diagnosed each year.
The most common symptoms of PF are shortness of breath, dry, and hacking cough, fast, and shallow breathing, tiredness, aching joints, and muscles and clubbing of the tips of the fingers or toes.
If you have experienced some of the aforementioned symptoms that do not heal in a short time, please check with your doctor to rule out the possibility.
Most cases of IPF are found in patients between the ages of 50 and 70 years old, particularly in men.
Dr. Selman M, the lead scientist in the joint study led by the Universidad Nacional Autónoma de México wrote, "Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to complex pathogenesis".
And, "Idiopathic pulmonary fibrosis occurs in middle-aged and mainly elderly adults, and in this context, age has emerged as its strongest risk factor. However, the mechanisms linking it to aging are uncertain".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of lung disease researchers examined the effects of lycopene extracted from tomatoes on pulmonary fibrosis PF induced by bleomycin BLM in rats.
The study included 60 Sprague-Dawley rats randomly divided into 3 groups of 20 rats each for a normal control group (group C), BLM-treated group (group M), and lycopene + BLM-treated group (group L).
More precisely, group L received lycopene diluted with olive oil at a dose of 5 mg/kg body weight once a day after BLM instillation, and groups C and M received the same amounts of olive oil.
Based on the tested analysis, group L showed a significantly reduced lung coefficient (day 14, P < .01) as well as the extents of alveolitis (day 7 and 14, P < .05) and pulmonary fibrosis PF (day 14 and 28, P < .05) compared to control.
The concentration of pro-inflammatory cytokines and oxidative stress markers in the lung also a significant decrease in the lycopene treatment group compared to control.
Based on the findings, researchers said, "lycopene can partially reduce the extent of PF induced by BLM in rats. These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of pulmonary fibrosis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats by Zhou C1, Han W, Zhang P, Cai M, Wei D, Zhang C. (PubMed)
(2) Aging and Pulmonary Fibrosis by Selman M1, Buendía-Roldán I1, Pardo A. (PubMed)
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The lung formed part of the respiratory system with a function of the primary organs of the respiratory system to absorb oxygen to the blood and shall carbon dioxide from the blood.
Pulmonary fibrosis (PF) is a condition associated with the formation of scars in the lungs. Over time, overexpression of scar tissue can destroy lung and interfere with the lung to take oxygen to the blood.
According to the American Lung Association, the most common PF is idiopathic pulmonary fibrosis. Approximately 50,000 new cases of IPF are diagnosed each year.
The most common symptoms of PF are shortness of breath, dry, and hacking cough, fast, and shallow breathing, tiredness, aching joints, and muscles and clubbing of the tips of the fingers or toes.
If you have experienced some of the aforementioned symptoms that do not heal in a short time, please check with your doctor to rule out the possibility.
Most cases of IPF are found in patients between the ages of 50 and 70 years old, particularly in men.
Dr. Selman M, the lead scientist in the joint study led by the Universidad Nacional Autónoma de México wrote, "Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to complex pathogenesis".
And, "Idiopathic pulmonary fibrosis occurs in middle-aged and mainly elderly adults, and in this context, age has emerged as its strongest risk factor. However, the mechanisms linking it to aging are uncertain".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of lung disease researchers examined the effects of lycopene extracted from tomatoes on pulmonary fibrosis PF induced by bleomycin BLM in rats.
The study included 60 Sprague-Dawley rats randomly divided into 3 groups of 20 rats each for a normal control group (group C), BLM-treated group (group M), and lycopene + BLM-treated group (group L).
More precisely, group L received lycopene diluted with olive oil at a dose of 5 mg/kg body weight once a day after BLM instillation, and groups C and M received the same amounts of olive oil.
Based on the tested analysis, group L showed a significantly reduced lung coefficient (day 14, P < .01) as well as the extents of alveolitis (day 7 and 14, P < .05) and pulmonary fibrosis PF (day 14 and 28, P < .05) compared to control.
The concentration of pro-inflammatory cytokines and oxidative stress markers in the lung also a significant decrease in the lycopene treatment group compared to control.
Based on the findings, researchers said, "lycopene can partially reduce the extent of PF induced by BLM in rats. These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of pulmonary fibrosis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats by Zhou C1, Han W, Zhang P, Cai M, Wei D, Zhang C. (PubMed)
(2) Aging and Pulmonary Fibrosis by Selman M1, Buendía-Roldán I1, Pardo A. (PubMed)
Friday, March 27, 2020
Herbal Comfrey(Symphytum officinale L.), the Potential and Natural Treatment of Myalgia
Myalgia is a group of diseases associated with muscle pain.
Most common types of myalgia are
* Systemic lupus erythematosus
The systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function that attacks healthy tissue in many parts of the body, inducing symptoms of severe fatigue, joint pain, swelling, and headaches.
*Systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue that may be misdiagnosed as rheumatoid arthritis. According to Dr. Horimoto AM and Dr. Costa IP, arthritis, clinically observed, maybe a feature often found in a patient with Systemic sclerosis, often leading to early misdiagnosis with rheumatoid arthritis (RA).
The most common symptoms of systemic sclerosis are hair loss, calcium deposits, or white lumps under the skin, small, dilated blood vessels under the skin's surface and joint pain.
* Polymyositis
Polymyositis (PM) is a type of chronic inflammation of the muscles associated with dermatomyositis and inclusion body myositis.
The most common system of polymyositis is muscle pain and stiffness, muscle weakness, particularly in the belly (abdomen), shoulders, upper arms, and hips and joint pain and stiffness.
The most common causes of myalgia are overuse, injury, or strain of muscles. However, myalgia can also be caused by diseases, medications, and in some, it is a response to vaccination.
Conventionally, most cases of myalgia are treated by over-the-counter medications such as Tylenol (acetaminophen) or nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with chronic pain, researchers investigated the effectiveness and tolerability of the topical Symphytum product Traumaplant (Harras Pharma Curarina, München, Germany) (10% active ingredient of a 2.5:1 aqueous-ethanolic pressed concentrate of freshly harvested, cultivated comfrey herb [Symphytum uplandicum Nyman], corresponding to 25 g of fresh herb per 100 g of cream) in the treatment of patients with myalgia (n=104) were tested against a 1% reference product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n=111).
According to the results from the primary efficacy parameter in this double-blind, reference- controlled, randomized, multicenter study of 215 patients with pain in the lower and upper back and motion and the. secondary efficacy parameters included pain at rest, pain on palpation, and functional impairment, high concentrations of the treatment product showed a significant amelioration of pain on active motion (P<5 x 10 -9 ), pain at rest (P<.001), and pain on palpation compared to the reference product which was clinically highly relevant.
The high-concentration product exerted a significantly better global efficacy and faster onset of effects.
Tolerability of the highly concentrated study product was good to excellent in all patients.
Based on the results, researchers said, "Study results confirm the known anti-inflammatory and analgesic effects of topical (Symphytum cream. As a new finding, applicability in certain forms of back pain can be concluded".
Taken altogether, Comfrey combined with other herbal medicine for the treatment of myalgia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study by Kucera M1, Barna M, Horàcek O, Kàlal J, Kucera A, Hladìkova M. (PubMed)
Most common types of myalgia are
* Systemic lupus erythematosus
The systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function that attacks healthy tissue in many parts of the body, inducing symptoms of severe fatigue, joint pain, swelling, and headaches.
*Systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue that may be misdiagnosed as rheumatoid arthritis. According to Dr. Horimoto AM and Dr. Costa IP, arthritis, clinically observed, maybe a feature often found in a patient with Systemic sclerosis, often leading to early misdiagnosis with rheumatoid arthritis (RA).
The most common symptoms of systemic sclerosis are hair loss, calcium deposits, or white lumps under the skin, small, dilated blood vessels under the skin's surface and joint pain.
* Polymyositis
Polymyositis (PM) is a type of chronic inflammation of the muscles associated with dermatomyositis and inclusion body myositis.
The most common system of polymyositis is muscle pain and stiffness, muscle weakness, particularly in the belly (abdomen), shoulders, upper arms, and hips and joint pain and stiffness.
The most common causes of myalgia are overuse, injury, or strain of muscles. However, myalgia can also be caused by diseases, medications, and in some, it is a response to vaccination.
Conventionally, most cases of myalgia are treated by over-the-counter medications such as Tylenol (acetaminophen) or nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with chronic pain, researchers investigated the effectiveness and tolerability of the topical Symphytum product Traumaplant (Harras Pharma Curarina, München, Germany) (10% active ingredient of a 2.5:1 aqueous-ethanolic pressed concentrate of freshly harvested, cultivated comfrey herb [Symphytum uplandicum Nyman], corresponding to 25 g of fresh herb per 100 g of cream) in the treatment of patients with myalgia (n=104) were tested against a 1% reference product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n=111).
According to the results from the primary efficacy parameter in this double-blind, reference- controlled, randomized, multicenter study of 215 patients with pain in the lower and upper back and motion and the. secondary efficacy parameters included pain at rest, pain on palpation, and functional impairment, high concentrations of the treatment product showed a significant amelioration of pain on active motion (P<5 x 10 -9 ), pain at rest (P<.001), and pain on palpation compared to the reference product which was clinically highly relevant.
The high-concentration product exerted a significantly better global efficacy and faster onset of effects.
Tolerability of the highly concentrated study product was good to excellent in all patients.
Based on the results, researchers said, "Study results confirm the known anti-inflammatory and analgesic effects of topical (Symphytum cream. As a new finding, applicability in certain forms of back pain can be concluded".
Taken altogether, Comfrey combined with other herbal medicine for the treatment of myalgia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study by Kucera M1, Barna M, Horàcek O, Kàlal J, Kucera A, Hladìkova M. (PubMed)
Thursday, March 26, 2020
Herbal Elecampane (Inula helenium), A Natural and Potential Neuroprotective Remedy
Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).
Alzheimer's disease is an irreversible, progressive brain disorder caused by the slowly lost of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into advanced stage.
According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.
There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical condition, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases
A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the neuroprotective effects of Costunolide (COS) is a natural sesquiterpene lactone originally isolated from Inula helenium (Compositae).
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.
The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.
According to tested analysis, on oxidative stress associated with the progression and pathogenesis of neurodegenerative diseases,
* COS showed strong activity in activating the expression of Nrf2 to counteract the oxidative injuries of PC12 cells.
* COS also exerted a cytotoxic effect in the regulation of cellular redox homeostasis through the expression of Nrf2 stimulation.
The results indicated that COS inhibited the levels of cellular reactive oxygen species level by restoring cellular thiol homeostasis, involved in maintaining the cellular redox balance.
In other words, treatment with COS promoted a range of antioxidant genes governed by Nrf2 and subsequently induced these gene expressions and activities against the overexpression of free radicals
Based on the results, researchers suggest, "COS provides neuroprotection via activating the Nrf2 signaling pathway in PC12 cells".
Taken altogether, Elecampane (Inula helenium) processed abundantly COS may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells by Peng S 1, Hou Y , Yao J , Fang J. (PubMed)
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).
Alzheimer's disease is an irreversible, progressive brain disorder caused by the slowly lost of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into advanced stage.
According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.
There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical condition, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases
A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the neuroprotective effects of Costunolide (COS) is a natural sesquiterpene lactone originally isolated from Inula helenium (Compositae).
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.
The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.
According to tested analysis, on oxidative stress associated with the progression and pathogenesis of neurodegenerative diseases,
* COS showed strong activity in activating the expression of Nrf2 to counteract the oxidative injuries of PC12 cells.
* COS also exerted a cytotoxic effect in the regulation of cellular redox homeostasis through the expression of Nrf2 stimulation.
The results indicated that COS inhibited the levels of cellular reactive oxygen species level by restoring cellular thiol homeostasis, involved in maintaining the cellular redox balance.
In other words, treatment with COS promoted a range of antioxidant genes governed by Nrf2 and subsequently induced these gene expressions and activities against the overexpression of free radicals
Based on the results, researchers suggest, "COS provides neuroprotection via activating the Nrf2 signaling pathway in PC12 cells".
Taken altogether, Elecampane (Inula helenium) processed abundantly COS may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells by Peng S 1, Hou Y , Yao J , Fang J. (PubMed)
Wednesday, March 25, 2020
Lycopene, the Anti-diabetic Nephropathy Phytochemical, Researchers Find
Diabetic nephropathy (diabetic kidney disease) is a complication of kidney damage in diabetes.
Long-term unmanaged hyperglycemia has been found to damage parts of the kidneys, leading to reduced kidney function in filter waste from the blood filters, resulting in a 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stages of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
The condition in the advanced stage can lead to symptoms of worsening blood pressure, protein in the urine, swelling of feet, ankles, hands or eyes, increased need to urinate, loss of appetite, nausea and vomiting, fatigue and persistent itching.
In severe cases, patients may also experience symptoms of confusion or difficulty concentrating.
More importantly, if high blood pressure is left uncontrolled, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly declines the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed.
Some researchers suggested that by maintaining healthy blood glucose levels and keeping them within the target range and a change of healthful diet accompanied by moderate exercise, diabetic nephropathy can be control
Dr. Chijoke Onyenwenyi, "Kidney disease is common in patients with type 1 and type 2 diabetes mellitus and is associated with adverse health outcomes, including progression to end-stage renal disease. In the general population, adherence to a healthy lifestyle is known to reduce the risk of cardiovascular events and death".
And, "Among individuals with diabetic kidney disease, modifications in lifestyle factors, including diet, physical activity, smoking habits, and body mass index, represent a promising cost-effective therapeutic adjunct to pharmacologic treatment of kidney disease incidence and progression".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potent compound for the treatment of diabetic complications, researchers examined the effects of lycopene, a carotenoid, on oxidative stress-induced the progression of diabetic nephropathy.
According to the tested assays, lycopene inhibited the menace ad oxidative stress and stress markers associated with advanced glycation end products (AGEs) both in vitro and in vivo.
Furthermore, lycopene decelerated the ribose induced AGE formation in the normal adult human kidney. (HK-2) cells and in rat kidneys thereby inhibiting the expression RAGE involved in the inflammatory response, leading to reduced levels of nuclear factor κB (NFκB) and matrix metalloproteinase 2 (MMP 2) expressions.
Where nuclear factor κB (NFκB) and matrix metalloproteinase 2 (MMP 2) expressions. are associated with cytokine production under oxidative stress.
Most importantly, nephropathy (DN) induced by the administration of ribose was totally inhibited by the injection of lycopene.
Based on the findings, researchers wrote, "lycopene provides protection against the development of diabetic nephropathy and ameliorates renal function by halting AGE-RAGE axis".
Taken altogether, lycopene found in tomato may be considered supplements for the protection against the risk of diabetic nephropathy in diabetics, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene powers the inhibition of glycation-induced diabetic nephropathy: a novel approach to halt the AGE-RAGE axis menace by Tabrez S1, Al-Shali KZ2, Ahmad S. (PubMed)
(2) Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress by Guo Y1, Liu Y, Wang Y. (PubMed)
(3) Impact of Lifestyle Modification on Diabetic Kidney Disease by Chijoke Onyenwenyi, MD and Ana C. Ricardo, MD, MPH. (PMC)
Long-term unmanaged hyperglycemia has been found to damage parts of the kidneys, leading to reduced kidney function in filter waste from the blood filters, resulting in a 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stages of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
The condition in the advanced stage can lead to symptoms of worsening blood pressure, protein in the urine, swelling of feet, ankles, hands or eyes, increased need to urinate, loss of appetite, nausea and vomiting, fatigue and persistent itching.
In severe cases, patients may also experience symptoms of confusion or difficulty concentrating.
More importantly, if high blood pressure is left uncontrolled, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly declines the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed.
Some researchers suggested that by maintaining healthy blood glucose levels and keeping them within the target range and a change of healthful diet accompanied by moderate exercise, diabetic nephropathy can be control
Dr. Chijoke Onyenwenyi, "Kidney disease is common in patients with type 1 and type 2 diabetes mellitus and is associated with adverse health outcomes, including progression to end-stage renal disease. In the general population, adherence to a healthy lifestyle is known to reduce the risk of cardiovascular events and death".
And, "Among individuals with diabetic kidney disease, modifications in lifestyle factors, including diet, physical activity, smoking habits, and body mass index, represent a promising cost-effective therapeutic adjunct to pharmacologic treatment of kidney disease incidence and progression".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potent compound for the treatment of diabetic complications, researchers examined the effects of lycopene, a carotenoid, on oxidative stress-induced the progression of diabetic nephropathy.
According to the tested assays, lycopene inhibited the menace ad oxidative stress and stress markers associated with advanced glycation end products (AGEs) both in vitro and in vivo.
Furthermore, lycopene decelerated the ribose induced AGE formation in the normal adult human kidney. (HK-2) cells and in rat kidneys thereby inhibiting the expression RAGE involved in the inflammatory response, leading to reduced levels of nuclear factor κB (NFκB) and matrix metalloproteinase 2 (MMP 2) expressions.
Where nuclear factor κB (NFκB) and matrix metalloproteinase 2 (MMP 2) expressions. are associated with cytokine production under oxidative stress.
Most importantly, nephropathy (DN) induced by the administration of ribose was totally inhibited by the injection of lycopene.
Based on the findings, researchers wrote, "lycopene provides protection against the development of diabetic nephropathy and ameliorates renal function by halting AGE-RAGE axis".
Taken altogether, lycopene found in tomato may be considered supplements for the protection against the risk of diabetic nephropathy in diabetics, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene powers the inhibition of glycation-induced diabetic nephropathy: a novel approach to halt the AGE-RAGE axis menace by Tabrez S1, Al-Shali KZ2, Ahmad S. (PubMed)
(2) Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress by Guo Y1, Liu Y, Wang Y. (PubMed)
(3) Impact of Lifestyle Modification on Diabetic Kidney Disease by Chijoke Onyenwenyi, MD and Ana C. Ricardo, MD, MPH. (PMC)
Tuesday, March 24, 2020
Omega-3 Fatty Acids May Be Used for the Treatment of Crohn's disease (CD)
Inflammatory bowel disease is a condition characterized by long term inflammation of the gut. The disease affects over 1.6 million Americans today.
The most common types of IBD are
*Crohn’s disease (CD) is an inflammation of any part of the digestive tract. Most cases of CD affect the tail end of the small intestine.
* Ulcerative colitis is an inflammation of the large intestine.
* Crohn's disease is a type of inflammatory bowel disease caused by inflammation in the gastrointestinal tract.
The exact cause of Crohn's disease is not identified. However, some researchers suggested that people with the compromised immune system and genetic preposition are prone to the disease onset compared to people who do not
The most common symptoms of Crohn's disease are abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.
Risk factors of Crohn's disease include aging, family and person history, ethnicity, smoking and long-term use of Nonsteroidal anti-inflammatory medications.
Conventionally, most cases of CD are treated by anti-inflammatory medications, corticosteroids, immunomodulators, and antibiotics.
According to the statistics by Crohn's & Colitis Foundation, the total number of new cases of Crohn's disease diagnosed each year was 10.7 per 100,000 people. In other words, approximately 33,000 new cases are diagnosed each year.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic inflammatory diseases, researchers examined the omega-3 supplementation by oral capsule for patients with Crohn's disease (CD).
The study included a total of 6 patients with CD in remission who participated in this open-label clinical trial and received one bottle (100 ml) of the test formulation (IMARK S®) daily for 28 days. After a 1-month washout period, patients ingested two bottles of the formulation daily for another 28 days.
According to the results of the anthropometric and blood tests,* There were no side effects with the quantity of the injection.
* The application did not alter the body weight and body-mass index in the participants.
* Most importantly, according to the CD activity index, participants showed a decrease in the scores after ingested one bottle of the formulation.
Based on the findings, researchers said, "Supplementation with an omega-3 emulsifying formulation can be safe and useful for maintaining remission in patients with CD and warrants further studies".
Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of Crohn's disease (CD), pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety of Emulsifying Lipid Formulation Containing Omega-3 Polyunsaturated Fatty Acids for Patients with Crohn's Disease by Yasueda A1, Shinzaki S2, Iijima H2, Mizushima T3, Nishimura J4, Hiyama S5, Ohno S1, Ito T. (PubMed)
Monday, March 23, 2020
Beta-Sitosterol Reduces Cholesterol Levels in Patients with cystic fibrosis
Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.
More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.
In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).
According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help to digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.
Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of diseases associated with hyper cholesterol, researchers elucidated the β-sitosterol effects in the plasma of patients with cystic fibrosis (CF).
The study included the plasma of 26 patients with CF and 33 unaffected controls that are treated by β-sitosterol and campesterol, using gas chromatography (GC-FID and GC-MS) assays.
Before the administration of β-sitosterol, the plasma level of cholesterol is higher in patients with CF compared to control subjects.
* Furthermore, plasma cholesterol treated by β-sitosterol was significantly lower in CF patients, compared to control.
* Moreover, β-sitosterol prevent the impaired intestinal absorption of exogenous sterols in patients with CF that stimulates the endogenous synthesis of cholesterol, without affecting the total cholesterol in plasma.
In other words, cystic fibrosis induced transmembrane conductance regulator (CFTR) dysfunction reduces cholesterol blood excretion causing the accumulation of cholesterol in liver cells and in other tissues that CF chronic inflammation.
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of hyper cholesterol in patients with CF, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Reduced absorption and enhanced synthesis of cholesterol in patients with cystic fibrosis: a preliminary study of plasma sterols by Gelzo M, Sica C, Elce A, Dello Russo A, Iacotucci P, Carnovale V, Raia V, Salvatore D, Corso G, Castaldo G. (PubMed)
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.
More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.
In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).
According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help to digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.
Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of diseases associated with hyper cholesterol, researchers elucidated the β-sitosterol effects in the plasma of patients with cystic fibrosis (CF).
The study included the plasma of 26 patients with CF and 33 unaffected controls that are treated by β-sitosterol and campesterol, using gas chromatography (GC-FID and GC-MS) assays.
Before the administration of β-sitosterol, the plasma level of cholesterol is higher in patients with CF compared to control subjects.
* Furthermore, plasma cholesterol treated by β-sitosterol was significantly lower in CF patients, compared to control.
* Moreover, β-sitosterol prevent the impaired intestinal absorption of exogenous sterols in patients with CF that stimulates the endogenous synthesis of cholesterol, without affecting the total cholesterol in plasma.
In other words, cystic fibrosis induced transmembrane conductance regulator (CFTR) dysfunction reduces cholesterol blood excretion causing the accumulation of cholesterol in liver cells and in other tissues that CF chronic inflammation.
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of hyper cholesterol in patients with CF, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Reduced absorption and enhanced synthesis of cholesterol in patients with cystic fibrosis: a preliminary study of plasma sterols by Gelzo M, Sica C, Elce A, Dello Russo A, Iacotucci P, Carnovale V, Raia V, Salvatore D, Corso G, Castaldo G. (PubMed)
Sunday, March 22, 2020
Phytochemical Sinigrin, Prevents Plaques Build-Up on the Arterial Wall Against the Onset of Atherosclerosis in Vivo
Sinigrin may be used as a natural and bioactive compound for the treatment of atherosclerosis, according to studies.
Atherosclerosis is a chronic and medical condition characterized by the plaque accumulated on the arterial wall, leading to stiffing and hardening arteries.
Arteries are the blood vessels that carry the oxygen-rich blood to the heart and other parts of the body.
Atherosclerosis is one of the leading cause of heart disease and stroke, depending on the area of blocking in the arteries.
Plaque is a combination of cholesterol, calcium, cadmium and other harmful chemical substances found in the blood.
The exact causes of atherosclerosis are not identified. Researchers as of today do not know why people with the same health condition, some are prone to the disease onset while others do not.
However, damage or injury of the inner layer of an artery, high blood pressure and cholesterol and medical conditions such as arthritis, lupus or infections, or inflammation of unknown cause have been found to increase the risk of atherosclerosis.
Due to plaque accumulation associated with high blood cholesterol, some researchers suggested that
an unhealthy diet high in saturated fat and trans fat may be the major cause as well as increasing the severity of the condition.
Dt. Zhao Y said, "The WZSPs (n = 9) were fed a high-cholesterol and high-fat diet (HCFD). After continuous feeding, 3 WZSPs each were sacrificed at 6, 8, and 12 months, respectively, and the general clinical manifestations and serological indexes were detected".
And, " At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".
The results clearly indicated the risk of atherosclerosis is substantially increased in animals fed with long-term high fat diet.
On finding a natural compound for the treatment of atherosclerosis with no side effects, researchers investigated sinigrin anti-plaque accumulation in an animal model.
In ApoE mice, the injection of sinigrin suppressed the expression of the genes directly involved in the formation of atherosclerotic lesions.
Sinigrin lowered the blood levels of cholesterol LDH, triglyceride, and cholesterol in serum without affecting the levels HDL. In other words, sinigrin promoted the return of blood cholesterol back to the liver, therefore, repressing the risk of cholesterol accompanied by other substances to form plaques on the arterial wall in facilitating the onset of atherosclerosis.
Furthermore, injection of sinigrin also promoted lipid homeostasis, through reducing levels of the proteins associated with lipid metabolism.
Moreover, the bioactive compound also reduced the production of proinflammatory cytokines induced by the overexpression of free radicals, and the accumulation of modified LDL within the intima of the artery.through its antioxidant activity.
More precisely, the bioactive compound reduced the expression of proinflammatory cytokines by suppressing the activation of the signaling protein associated with a wide range of processes such as immunity, inflammation.
In ApoE-/- mice induced atherosclerosis, the application of sinigrin exerted a similar effect by reducing the levels of serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines.
Oral administration of sinigrin attenuated the expression of proteins involved in the initiation of atherosclerosis.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of atherosclerosis, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(3) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)
Atherosclerosis is a chronic and medical condition characterized by the plaque accumulated on the arterial wall, leading to stiffing and hardening arteries.
Arteries are the blood vessels that carry the oxygen-rich blood to the heart and other parts of the body.
Atherosclerosis is one of the leading cause of heart disease and stroke, depending on the area of blocking in the arteries.
Plaque is a combination of cholesterol, calcium, cadmium and other harmful chemical substances found in the blood.
The exact causes of atherosclerosis are not identified. Researchers as of today do not know why people with the same health condition, some are prone to the disease onset while others do not.
However, damage or injury of the inner layer of an artery, high blood pressure and cholesterol and medical conditions such as arthritis, lupus or infections, or inflammation of unknown cause have been found to increase the risk of atherosclerosis.
Due to plaque accumulation associated with high blood cholesterol, some researchers suggested that
an unhealthy diet high in saturated fat and trans fat may be the major cause as well as increasing the severity of the condition.
Dt. Zhao Y said, "The WZSPs (n = 9) were fed a high-cholesterol and high-fat diet (HCFD). After continuous feeding, 3 WZSPs each were sacrificed at 6, 8, and 12 months, respectively, and the general clinical manifestations and serological indexes were detected".
And, " At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".
The results clearly indicated the risk of atherosclerosis is substantially increased in animals fed with long-term high fat diet.
On finding a natural compound for the treatment of atherosclerosis with no side effects, researchers investigated sinigrin anti-plaque accumulation in an animal model.
In ApoE mice, the injection of sinigrin suppressed the expression of the genes directly involved in the formation of atherosclerotic lesions.
Sinigrin lowered the blood levels of cholesterol LDH, triglyceride, and cholesterol in serum without affecting the levels HDL. In other words, sinigrin promoted the return of blood cholesterol back to the liver, therefore, repressing the risk of cholesterol accompanied by other substances to form plaques on the arterial wall in facilitating the onset of atherosclerosis.
Furthermore, injection of sinigrin also promoted lipid homeostasis, through reducing levels of the proteins associated with lipid metabolism.
Moreover, the bioactive compound also reduced the production of proinflammatory cytokines induced by the overexpression of free radicals, and the accumulation of modified LDL within the intima of the artery.through its antioxidant activity.
More precisely, the bioactive compound reduced the expression of proinflammatory cytokines by suppressing the activation of the signaling protein associated with a wide range of processes such as immunity, inflammation.
In ApoE-/- mice induced atherosclerosis, the application of sinigrin exerted a similar effect by reducing the levels of serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines.
Oral administration of sinigrin attenuated the expression of proteins involved in the initiation of atherosclerosis.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of atherosclerosis, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(3) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)
Saturday, March 21, 2020
Gamma-Linolenic Acid, The Potential Anti-Atherosclerotic Lesions in Vivo
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.
Some researchers suggested that atherosclerosis may be caused by long term high blood pressure,
high cholesterol and triglycerides (a type of fat) in the blood. Particularly, in high levels of insulin in the blood from diabetes and in exposure to chemicals from smoking tobacco.
Patients with early stages of atherosclerosis may not experience any symptoms. However, as the disease progress, patients may have the symptoms of chest pain if the blockage occurs in an artery of the heart (coronary artery) and leg cramps during exercise or walking if the blockage occurs in the legs.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant for the prevention and treatment of atherosclerosis, researchers examined the effect of the effects of D5D inhibition by a D5D inhibitor on atherosclerosis.
Where Delta-5 desaturase (D5D), encoded by fatty acid desaturase 1 (Fads1), is the rate-limiting enzyme for the conversion from dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) in the ω-6 polyunsaturated fatty acid pathway.
According to the results of the analysis of the Western-diet fed ApoE knockout (KO) mice,
* Oral administration of compound-326 (3-10 mg/kg per day for 15 weeks) significantly inhibited the progression of atherosclerotic lesions in the aorta without affecting plasma total cholesterol and triglyceride levels.
* Compound-326 significantly decreased AA levels, while it increased DGLA levels in the liver and the blood accompanied by decreases in AA-derived eicosanoid production and increases in DGLA-derived eicosanoid production from the blood cells.
In other words, the compound-326 prevents the progression of atherosclerosis in Western-diet fed ApoE KO mice by modulating a profile of eicosanoid production.
Collectively, researchers said, "D5D inhibitors can be a novel remedy for preventing atherosclerosis and subsequent cardiovascular events".
Taken altogether, Gamma-linolenic Acid may be considered a remedy for the prevention and treatment of atherosclerotic lesions,, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice by Takagahara S1, Shinohara H2, Itokawa S2, Satomi Y2, Ando A2, Yamamoto T2, Suzuki H2, Fujimoto T2, Kubo K2, Ikeda S. (PubMed)
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.
Some researchers suggested that atherosclerosis may be caused by long term high blood pressure,
high cholesterol and triglycerides (a type of fat) in the blood. Particularly, in high levels of insulin in the blood from diabetes and in exposure to chemicals from smoking tobacco.
Patients with early stages of atherosclerosis may not experience any symptoms. However, as the disease progress, patients may have the symptoms of chest pain if the blockage occurs in an artery of the heart (coronary artery) and leg cramps during exercise or walking if the blockage occurs in the legs.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant for the prevention and treatment of atherosclerosis, researchers examined the effect of the effects of D5D inhibition by a D5D inhibitor on atherosclerosis.
Where Delta-5 desaturase (D5D), encoded by fatty acid desaturase 1 (Fads1), is the rate-limiting enzyme for the conversion from dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) in the ω-6 polyunsaturated fatty acid pathway.
According to the results of the analysis of the Western-diet fed ApoE knockout (KO) mice,
* Oral administration of compound-326 (3-10 mg/kg per day for 15 weeks) significantly inhibited the progression of atherosclerotic lesions in the aorta without affecting plasma total cholesterol and triglyceride levels.
* Compound-326 significantly decreased AA levels, while it increased DGLA levels in the liver and the blood accompanied by decreases in AA-derived eicosanoid production and increases in DGLA-derived eicosanoid production from the blood cells.
In other words, the compound-326 prevents the progression of atherosclerosis in Western-diet fed ApoE KO mice by modulating a profile of eicosanoid production.
Collectively, researchers said, "D5D inhibitors can be a novel remedy for preventing atherosclerosis and subsequent cardiovascular events".
Taken altogether, Gamma-linolenic Acid may be considered a remedy for the prevention and treatment of atherosclerotic lesions,, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice by Takagahara S1, Shinohara H2, Itokawa S2, Satomi Y2, Ando A2, Yamamoto T2, Suzuki H2, Fujimoto T2, Kubo K2, Ikeda S. (PubMed)
Thursday, March 19, 2020
Lycopene Processes Anti OverGrowth of Candida Albicans
Fungal infectious disease occurs mostly in patients with a weakened immune system characterized by the disease caused by overexpression of specific fungal.
The most common mild fungal skin diseases can induce symptoms of a rash that may go away if the fungal infection is cured.
Candida is a class of yeasts that cause fungal infections worldwide. Under normal conditions, candida does not cause any health issue if they live outside of the body including on the surface of the skin. However, Candida can cause a significant health problem if they grow out of control in the deeper parts of the body, leading to candidiasis.
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Oral candidiasis is an oral condition infected by the fungal C. Albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging due to a weaken the immune system may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of fungal infection, researchers examined the role of lycopene on C. Albicans.
In fungal infection, lycopene exerted potent antifungal effects on pathogenic fungi, including C. Albicans in an energy-independent manner.
In Candida albicans induced by fetal bovine serum (FBS) inhibited C, Albicans by causing significant membrane damage and blocking the normal budding process.
In other words, the injection of lycopene induced C. Albicans apoptosis by the destruction of membrane integrity.
Based on the findings, researchers said, "indicates that lycopene has considerable antifungal activity, deserving further investigation for clinical applications".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of C. Albicans infection, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans by Sung WS1, Lee IS, Lee DG. (PubMed)
(2)
Treatment of invasive candidiasis in the elderly: a review by Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 and George Dimopoulos. (PMC)
The most common mild fungal skin diseases can induce symptoms of a rash that may go away if the fungal infection is cured.
Candida is a class of yeasts that cause fungal infections worldwide. Under normal conditions, candida does not cause any health issue if they live outside of the body including on the surface of the skin. However, Candida can cause a significant health problem if they grow out of control in the deeper parts of the body, leading to candidiasis.
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Oral candidiasis is an oral condition infected by the fungal C. Albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging due to a weaken the immune system may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of fungal infection, researchers examined the role of lycopene on C. Albicans.
In fungal infection, lycopene exerted potent antifungal effects on pathogenic fungi, including C. Albicans in an energy-independent manner.
In Candida albicans induced by fetal bovine serum (FBS) inhibited C, Albicans by causing significant membrane damage and blocking the normal budding process.
In other words, the injection of lycopene induced C. Albicans apoptosis by the destruction of membrane integrity.
Based on the findings, researchers said, "indicates that lycopene has considerable antifungal activity, deserving further investigation for clinical applications".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of C. Albicans infection, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans by Sung WS1, Lee IS, Lee DG. (PubMed)
(2)
Treatment of invasive candidiasis in the elderly: a review by Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 and George Dimopoulos. (PMC)
Moronic acid, the Anti-Herpes Simplex Virus Supplement
Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.
Anti-viral effects are an act of certain substances to cause the destruction of a virus.
Herpes simplex virus 1 and 2, the 2 members of the herpesvirus family, also are best known as human herpesvirus 1 and 2.
The classification of the virus is based on their likelihood to cause infection. According to WHO(5), in the expression of conventional medicine, there is no cure for the diseases and both HSV-1 and HSV-2 infections are lifelong.
* HSV-1 is mainly transmitted by oral-to-oral contact such as oral herpes.
* HSV-2 is a sexually transmitted infection.
However, both HSV-1 and HSV-2 can cause genital herpes.
According to statistics, approximately 3.7 billion people under age 50 (67%) are infected by HSV-1 and 417 million people aged 15-49 (11%) are infected by HSV-2 globally.
Some patients infected by the virus do not experience any symptoms, however, some may affect by symptoms of painful blisters or ulcers at the site of infection.
The virus is very contagious in the presence of symptoms but they can also transmit to others from virus carriers who experience no symptoms at all.
Moronic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
On finding a potential phytochemical for the treatment of infectious diseases, researchers examined
anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.
According to the results from the experimental model,
* Moronic acid was quantitatively a major anti-HSV compound in the ethyl acetate-soluble fraction.
* The effective concentrations for 50% plaque reduction of moronic acid for wild-type HSV type 1 (HSV-1) were 3.9 microgram/ml.
* The oral administration of moronic acid on mice infected cutaneously with HSV-1 three times daily significantly retarded the development of skin lesions and/or prolonged the mean survival times of infected mice without inducing toxicity, compared with the control.
* Moreover, moronic acid suppressed virus yields in the brain more efficiently than those in the skin.
Based on the findings, researchers said, "Moronic acid showed oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity that was consistent with that of the extract".
Taken altogether, moronic acid may be considered an anti-herpes simplex virus supplement, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo by Kurokawa M1, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K. (PubMed)
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.
Anti-viral effects are an act of certain substances to cause the destruction of a virus.
Herpes simplex virus 1 and 2, the 2 members of the herpesvirus family, also are best known as human herpesvirus 1 and 2.
The classification of the virus is based on their likelihood to cause infection. According to WHO(5), in the expression of conventional medicine, there is no cure for the diseases and both HSV-1 and HSV-2 infections are lifelong.
* HSV-1 is mainly transmitted by oral-to-oral contact such as oral herpes.
* HSV-2 is a sexually transmitted infection.
However, both HSV-1 and HSV-2 can cause genital herpes.
According to statistics, approximately 3.7 billion people under age 50 (67%) are infected by HSV-1 and 417 million people aged 15-49 (11%) are infected by HSV-2 globally.
Some patients infected by the virus do not experience any symptoms, however, some may affect by symptoms of painful blisters or ulcers at the site of infection.
The virus is very contagious in the presence of symptoms but they can also transmit to others from virus carriers who experience no symptoms at all.
Moronic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
On finding a potential phytochemical for the treatment of infectious diseases, researchers examined
anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.
According to the results from the experimental model,
* Moronic acid was quantitatively a major anti-HSV compound in the ethyl acetate-soluble fraction.
* The effective concentrations for 50% plaque reduction of moronic acid for wild-type HSV type 1 (HSV-1) were 3.9 microgram/ml.
* The oral administration of moronic acid on mice infected cutaneously with HSV-1 three times daily significantly retarded the development of skin lesions and/or prolonged the mean survival times of infected mice without inducing toxicity, compared with the control.
* Moreover, moronic acid suppressed virus yields in the brain more efficiently than those in the skin.
Based on the findings, researchers said, "Moronic acid showed oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity that was consistent with that of the extract".
Taken altogether, moronic acid may be considered an anti-herpes simplex virus supplement, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo by Kurokawa M1, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K. (PubMed)
Wednesday, March 18, 2020
Herbal Devil's claw (Harpagophytum procumbens) Improves the Symptoms and Quality of Life in Gonarthritis Patients
Arthritis is a general form of the inflammatory disease associated with the inflammation of one or more joints.
The most common symptoms are joint pain and stiffness found mostly in the aging population.
The most common types of arthritis that affect people in the US are osteoarthritis and rheumatoid arthritis.
The most common caused of arthritis is a joint injury that did not heal properly, metabolic abnormalities caused by overexpression of uric acid and infection-induced bacteria or virus.
However, there are some cases of arthritis caused by autoimmunity, a condition in which the immune system mistakenly attacks the joint tissues, such as in rheumatoid arthritis and systemic lupus erythematosus.
According to the information provided by the Arthritis Foundation, in the US, approximately 54 million adults are living with the condition.
Believe it or not, Almost 300,000 babies and children have arthritis or a rheumatic condition.
Gonarthritis is a type of arthritis associated with ankle degenerative disorder involved in the knee joint related to overload, or to age or systemic diseases, accompanied by inflammation in some cases.
The first symptom of gonarthritis is a pain in the knee, including the initiation of a prolonged period of inactivity or rest.
In other words, the initial pain only begins to subside after a few minutes, or after taking a few steps.
On finding a natural ingredient for the prevention and treatment of arthritis, scientists examined the formulation MA212 (Rosaxan), a composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devil's claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract on symptoms of gonarthritis Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.
The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.
According to the 12-week randomized, placebo-controlled double-blind parallel-design study of 92 patients who were treated either by MA212 (40 mL, n = 46) or placebo (n = 44) daily, * The initial WOMAC subscores/scores did not differ between groups.
* During the study, their means significantly improved in both groups.
* The pre-post change of the WOMAC pain score (primary endpoint) was 29.87 in the MA212 group and 10.23 in the placebo group.
In other words, the MA212 group exerted a strong and significant superiority in the improvement of the symptoms of gonarthritis compared to the placebo group.
* MA212 group showed both physical and mental quality of life significant improvement compared to placebo,
* Furthermore, there was a trend towards reduced analgesics consumption with MA212, compared to placebo
Moreover, researchers suggest, "physicians (pChi < 0.001) and patients (pChi < 0.001) rated MA212 superior to placebo. MA212 was well tolerated. This study demonstrates excellent efficacy for MA212 in gonarthritis patients".
Taken altogether, Devil's claw (Harpagophytum procumbens) used alone or combined with other herbal medicine may be considered a decoction for the improvement of gonarthritis symptoms, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Rosa canina - Urtica dioica - Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study by Moré M1, Gruenwald J1, Pohl U2, Uebelhack R. (PubMed).
The most common symptoms are joint pain and stiffness found mostly in the aging population.
The most common types of arthritis that affect people in the US are osteoarthritis and rheumatoid arthritis.
The most common caused of arthritis is a joint injury that did not heal properly, metabolic abnormalities caused by overexpression of uric acid and infection-induced bacteria or virus.
However, there are some cases of arthritis caused by autoimmunity, a condition in which the immune system mistakenly attacks the joint tissues, such as in rheumatoid arthritis and systemic lupus erythematosus.
According to the information provided by the Arthritis Foundation, in the US, approximately 54 million adults are living with the condition.
Believe it or not, Almost 300,000 babies and children have arthritis or a rheumatic condition.
Gonarthritis is a type of arthritis associated with ankle degenerative disorder involved in the knee joint related to overload, or to age or systemic diseases, accompanied by inflammation in some cases.
The first symptom of gonarthritis is a pain in the knee, including the initiation of a prolonged period of inactivity or rest.
In other words, the initial pain only begins to subside after a few minutes, or after taking a few steps.
On finding a natural ingredient for the prevention and treatment of arthritis, scientists examined the formulation MA212 (Rosaxan), a composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devil's claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract on symptoms of gonarthritis Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.
The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.
According to the 12-week randomized, placebo-controlled double-blind parallel-design study of 92 patients who were treated either by MA212 (40 mL, n = 46) or placebo (n = 44) daily, * The initial WOMAC subscores/scores did not differ between groups.
* During the study, their means significantly improved in both groups.
* The pre-post change of the WOMAC pain score (primary endpoint) was 29.87 in the MA212 group and 10.23 in the placebo group.
In other words, the MA212 group exerted a strong and significant superiority in the improvement of the symptoms of gonarthritis compared to the placebo group.
* MA212 group showed both physical and mental quality of life significant improvement compared to placebo,
* Furthermore, there was a trend towards reduced analgesics consumption with MA212, compared to placebo
Moreover, researchers suggest, "physicians (pChi < 0.001) and patients (pChi < 0.001) rated MA212 superior to placebo. MA212 was well tolerated. This study demonstrates excellent efficacy for MA212 in gonarthritis patients".
Taken altogether, Devil's claw (Harpagophytum procumbens) used alone or combined with other herbal medicine may be considered a decoction for the improvement of gonarthritis symptoms, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Rosa canina - Urtica dioica - Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study by Moré M1, Gruenwald J1, Pohl U2, Uebelhack R. (PubMed).
Gamma-linolenic Acid Reduces the Risk of Non-Ischemic Heart Failure
The heart is a four-chambered, hollow muscle and a double-acting pump located in the chest between the lungs is a muscular organ in the human body.
The heart formed an important part of the circulatory system that pumps blood through the blood vessels to nourish the body and assist in the removal of metabolic wastes.
Non-ischemic Heart Failure is a type of heart failure that is not associated with ischemic heart failure.
According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. Cardiovascular disease (CVD) accounted for 840,678 deaths in the US in 2016 and the condition also claims more lives each year than all forms of cancer and chronic lower respiratory disease combined
In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).
Ischemic heart disease is defined as a condition of reduced blood supply of the heart muscle, as a result of coronary artery disease caused by plaque building up in the arteries.
Heart failure is a medical condition characterized by insufficiently maintaining blood flow to meet the body's needs, inducing symptoms of
* Shortness of breath and excessive tiredness are caused by the congestion in your lungs in the process of inhaling oxygen and exhaling carbon dioxide.
And* Leg swelling is a condition caused by fluid to back up in your lungs and in other parts of your body such as your ankles.
Believe it or not, approximately 600, 000 Canadian are living with heart failure or 16% of the entire population.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-heart diseases activity researchers examined the effect of polyunsaturated fatty acids (PUFAs) on heart failure (HF).
The study included 50 patients with stable non-ischemic HF who underwent CPETs at our hospital.
According to the results of the analysis of the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters in patients' data.
* Correlations were significantly negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and heart failure.
* Minute ventilation versus carbon dioxide production (VE/VCO2) slope, were positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope in heart failure.
* More profoundly, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters.
Based on the evidence, researchers said, " Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF".
Taken altogether, potato may be considered a functional food for the prevention and treatment of non-ischemic heart failure, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure by Izumida S1, Kawano H1, Muroya T2, Motokawa T1, Akashi R1, Yonekura T1, Morimoto Y3, Yano Y3, Ikeda S1, Maemura K. (PubMed)
The heart formed an important part of the circulatory system that pumps blood through the blood vessels to nourish the body and assist in the removal of metabolic wastes.
Non-ischemic Heart Failure is a type of heart failure that is not associated with ischemic heart failure.
According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. Cardiovascular disease (CVD) accounted for 840,678 deaths in the US in 2016 and the condition also claims more lives each year than all forms of cancer and chronic lower respiratory disease combined
In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).
Ischemic heart disease is defined as a condition of reduced blood supply of the heart muscle, as a result of coronary artery disease caused by plaque building up in the arteries.
Heart failure is a medical condition characterized by insufficiently maintaining blood flow to meet the body's needs, inducing symptoms of
* Shortness of breath and excessive tiredness are caused by the congestion in your lungs in the process of inhaling oxygen and exhaling carbon dioxide.
And* Leg swelling is a condition caused by fluid to back up in your lungs and in other parts of your body such as your ankles.
Believe it or not, approximately 600, 000 Canadian are living with heart failure or 16% of the entire population.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-heart diseases activity researchers examined the effect of polyunsaturated fatty acids (PUFAs) on heart failure (HF).
The study included 50 patients with stable non-ischemic HF who underwent CPETs at our hospital.
According to the results of the analysis of the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters in patients' data.
* Correlations were significantly negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and heart failure.
* Minute ventilation versus carbon dioxide production (VE/VCO2) slope, were positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope in heart failure.
* More profoundly, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters.
Based on the evidence, researchers said, " Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF".
Taken altogether, potato may be considered a functional food for the prevention and treatment of non-ischemic heart failure, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure by Izumida S1, Kawano H1, Muroya T2, Motokawa T1, Akashi R1, Yonekura T1, Morimoto Y3, Yano Y3, Ikeda S1, Maemura K. (PubMed)
Tuesday, March 17, 2020
Lycopene Protects the Kidney and Heart Cells Against Nephrotoxicity and Cardiotoxicity
Nephrotoxicity is toxicity in the kidneys associated with reduced function of the kidney due to toxic chemicals, and medications.
The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.
Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorb back substances, and secret waste such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Furthermore, kidneys also process the functions that regulate electrolytes, blood pressure, maintains acid-base balance, produce hormone calcitriol, renin, and erythropoietin, etc.
In the urinary system, the kidney also reabsorbed back substances into the blood, while others waste, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
The most common symptoms of nephrotoxicity decreased urine output, fluid retention, causing swelling in your legs, ankles or feet, weakness, fatigue, and irregular heartbeat.
In severe cases, patients may also experience symptoms of shortness of breath, and confusion.
Cardiotoxicity, on the other hand, is toxicity in the heart associated with reduced heart muscle capacity in the blood circulation due to toxic chemicals, and medications.
The heart, a four-chambered, hollow muscle and double acting pump that is located in the chest between the lungs is a muscular organ in the human body processed the function that pumps blood through the blood vessels of the circulatory system to nourish the body and assist in the removal of metabolic wastes.
According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Compared to nephrotoxicity, patients with cardiotoxicity may have symptoms of fatigue, shortness of breath on exertion, worsening to shortness of breath at rest, discomfort lying on your back and welling of the ankles.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound that processes cardio and nephroprotective effects, researchers examined the effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in kidney and heart of experimental rats.
A total of 42 healthy three-month-old male Wistar-Albino rats were randomly divided into six experimental groups including 7 rats in each as following control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.
Compared to AFB1 and according to the tested analysis, the elevated levels of malondialdehyde (MDA) levels associated with oxidative stress markers were significantly decreased in the lycopene treatment group.
The reduced levels of antioxidant enzymes in the AFB1 group such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities were increased substantially in kidney and heart tissues upon the injection of lycopene.
Furthermore, the non-enzymatic antioxidant system in AFB treated rats that cause the rise of oxidative stress in the rat kidney and heart were also inhibited by the administration of lycopene.
Moreover, lycopene also inhibited the increased urea, creatinine levels, and reduced-sodium concentrations in plasma of AFB1 treated rats.
Based on the findings, researchers said, "There was lycopene showed protection against AF induced nephrotoxicity and cardiotoxicity".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of osteoporotic fractures, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment by Anjos Ferreira AL1, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. (PubMed)
The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.
Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorb back substances, and secret waste such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Furthermore, kidneys also process the functions that regulate electrolytes, blood pressure, maintains acid-base balance, produce hormone calcitriol, renin, and erythropoietin, etc.
In the urinary system, the kidney also reabsorbed back substances into the blood, while others waste, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
The most common symptoms of nephrotoxicity decreased urine output, fluid retention, causing swelling in your legs, ankles or feet, weakness, fatigue, and irregular heartbeat.
In severe cases, patients may also experience symptoms of shortness of breath, and confusion.
Cardiotoxicity, on the other hand, is toxicity in the heart associated with reduced heart muscle capacity in the blood circulation due to toxic chemicals, and medications.
The heart, a four-chambered, hollow muscle and double acting pump that is located in the chest between the lungs is a muscular organ in the human body processed the function that pumps blood through the blood vessels of the circulatory system to nourish the body and assist in the removal of metabolic wastes.
According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Compared to nephrotoxicity, patients with cardiotoxicity may have symptoms of fatigue, shortness of breath on exertion, worsening to shortness of breath at rest, discomfort lying on your back and welling of the ankles.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound that processes cardio and nephroprotective effects, researchers examined the effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in kidney and heart of experimental rats.
A total of 42 healthy three-month-old male Wistar-Albino rats were randomly divided into six experimental groups including 7 rats in each as following control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.
Compared to AFB1 and according to the tested analysis, the elevated levels of malondialdehyde (MDA) levels associated with oxidative stress markers were significantly decreased in the lycopene treatment group.
The reduced levels of antioxidant enzymes in the AFB1 group such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities were increased substantially in kidney and heart tissues upon the injection of lycopene.
Furthermore, the non-enzymatic antioxidant system in AFB treated rats that cause the rise of oxidative stress in the rat kidney and heart were also inhibited by the administration of lycopene.
Moreover, lycopene also inhibited the increased urea, creatinine levels, and reduced-sodium concentrations in plasma of AFB1 treated rats.
Based on the findings, researchers said, "There was lycopene showed protection against AF induced nephrotoxicity and cardiotoxicity".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of osteoporotic fractures, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment by Anjos Ferreira AL1, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. (PubMed)
Ursolic acid Protects Diabetes Against Kidney Injury in Vivo
Diabetic kidney disease is a type of kidney disease caused by diabetes.
Kidneys, a pair of the bean-shaped organ in the human body not only filter out blood but also balances the body fluids by eliminating them and removes them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
The most common kidney injury is associated with scar tissues forming in the kidneys.
Renal fibrosis is a condition of abnormal healing of the kidney tissues after injury, caused by the formation of scars in the kidney.
Renal scarring has been found to gradually reduced the renal function, leading to end-stage renal failure, depending on the severity and the area of scarring forming.
Patients at the end stage of renal failure may require dialysis or kidney transplantation.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
On finding a potential phytochemical for the treatment of kidney diseases, researchers examined the effects of ursolic acid (UA) mitigating renal inflammation, oxidative stress, and fibrosis.
The study included db/db mice that were divided randomly into a diabetic nephropathy (DN) group and a UA treatment group.
According to the analysis,
* UA treatment effectively reduced the body weights and blood glucose levels of db/db mice (p<0.05) as well as the urinary albumin/creatinine ratio (p<0.05).
* UA significantly improved the renal tissue lesions and glomerulosclerosis index of the db/db mice.after treatment (p<0.01).
* UA treatment also significantly lower expression levels of proteins associated with kidney injury and pro-inflammatory cytokines IL-1β and IL-18 in renal tissues, compared to the DN group.
In other words, researchers said, "UA alleviated renal damage in type 2 diabetic db/db mice by downregulating proteins in the ARAP1/AT1R signaling pathway to inhibit extracellular matrix accumulation, renal inflammation, fibrosis, and oxidative stress.".
Taken altogether, ursolic acid may be considered adjunct therapies in the treatment of diabetic kidney injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway by Ma TK#1, Xu L#1,2, Lu LX#1,3, Cao X1, Li X1, Li LL1, Wang X4, Fan QL. (PubMed).
Kidneys, a pair of the bean-shaped organ in the human body not only filter out blood but also balances the body fluids by eliminating them and removes them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
The most common kidney injury is associated with scar tissues forming in the kidneys.
Renal fibrosis is a condition of abnormal healing of the kidney tissues after injury, caused by the formation of scars in the kidney.
Renal scarring has been found to gradually reduced the renal function, leading to end-stage renal failure, depending on the severity and the area of scarring forming.
Patients at the end stage of renal failure may require dialysis or kidney transplantation.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
On finding a potential phytochemical for the treatment of kidney diseases, researchers examined the effects of ursolic acid (UA) mitigating renal inflammation, oxidative stress, and fibrosis.
The study included db/db mice that were divided randomly into a diabetic nephropathy (DN) group and a UA treatment group.
According to the analysis,
* UA treatment effectively reduced the body weights and blood glucose levels of db/db mice (p<0.05) as well as the urinary albumin/creatinine ratio (p<0.05).
* UA significantly improved the renal tissue lesions and glomerulosclerosis index of the db/db mice.after treatment (p<0.01).
* UA treatment also significantly lower expression levels of proteins associated with kidney injury and pro-inflammatory cytokines IL-1β and IL-18 in renal tissues, compared to the DN group.
In other words, researchers said, "UA alleviated renal damage in type 2 diabetic db/db mice by downregulating proteins in the ARAP1/AT1R signaling pathway to inhibit extracellular matrix accumulation, renal inflammation, fibrosis, and oxidative stress.".
Taken altogether, ursolic acid may be considered adjunct therapies in the treatment of diabetic kidney injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway by Ma TK#1, Xu L#1,2, Lu LX#1,3, Cao X1, Li X1, Li LL1, Wang X4, Fan QL. (PubMed).
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