Potatoes May Protect the Liver Cells Against the Development of Fibrosis, Researchers Say

Fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the organ tissues In other words, hepatic fibrosis is a portion of the liver which was affected by scars formation.

The exact causes of fibrosis are unknown. However, certain risk factors such as repeated liver injury caused by a virus infection, and a blockage in the bile ducts are found to elaborate on the onset of fibrosis.

The 2 most common types of fibrosis in the human body are
* Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support of surrounding the renal cells during aging and chronic kidney disease (CKD).

According to the statistics, CKD and renal fibrosis affect approximately half of the adults age 70 and over and 10% of the world's population.

In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.

Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.

* Liver fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.

The severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death of 12/100,000 of the population every year.

The most common causes of liver fibrosis are excessive alcohol drinking and infected by the hepatitis virus.

Long-term untreated liver fibrosis can lead to cirrhosis, a condition of the severe scarring of the liver and life-threatening liver disease.

Potato is a genus Solanum, belongs to the family Solanaceae. the root veggie is a good source of protein.
According to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. Potato now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

On finding a potential plant that processes anti-fibrotic activity researchers examined the effect of APPH, a potato protein hydrolysate on a high-fat diet (HFD) associated liver damages.

The study included six-week-old male hamsters that were randomly separated to six groups (n = 8) as control, HFD (HFD fed obese), L-APPH (HFD + 15 mg/kg/day of APPH), M-APPH (HFD + 30 mg/kg/day), H-APPH (HFD + 75 mg/kg/day of APPH) and PB (HFD + 500 mg/kg/day of probucol) with HFD fed hamsters were administered with APPH 50 days through oral gavage.

According to the results of the analysis,* Hamsters fed with a high-fat diet showed symptoms of liver damage as measured from serum stress markers like alanine aminotransferase and aspartate aminotransferase levels.
* Furthermore, HFD also modulated the expression of survival and apoptosis proteins in the hamster liver.

* Moreover, the HFD groups showed elevated levels of fibrosis markers in the liver correlated with the increase in the levels of phosphorylated extracellular signal-regulated kinases (pERK1/2) induced liver cell differentiation in the HFD mediated liver damage.


* The administration of a 50-day long supplementation of APPH effectively ameliorated the effects of HFD.

* APPH treatment reduced the effect of HFD on the apoptosis and fibrosis markers considerably and provided hepato-protection.

Collectively, researchers said, "APPH can, therefore, be considered as an efficient therapeutic agent to ameliorate high-fat diet-related liver damages".

Taken altogether, potato may be considered a functional food for the prevention and treatment of liver fibrosis and damage induced fibrosis, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protein hydrolysate from potato confers hepatic-protection in hamsters against high fat diet induced apoptosis and fibrosis by suppressing Caspase-3 and MMP2/9 and by enhancing Akt-survival pathway by Asokan SM1,2, Hung TH3, Li ZY3, Chiang WD4, Lin WT. (PubMed)