Pinto Beans, the Promising Anti-Type-2 Diabetes Functional Food, According to Study

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Researchers do not know what causes the pancreas to die off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, gestation diabetes, are associated with an increased risk of type 2 diabetes.

Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.

The most common symptoms of diabetes are excessive thirst and hunger, frequent urination, unintended weight loss or gain, frequent fatigue, irritability and gastrointestinal symptoms such as nausea.

In severe cases, patients may also experience symptoms of blurred vision and slow wound healing or ulcer.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy). ...

On finding a natural ingredient for the prevention and treatment of chronic diseases associated with oxidative stress, scientists examined the effects of bioactive peptide fractions from de-hulled hard-to-cook (HTC) bean on enzyme targets of type-2 diabetes and oxidative stress.
The tested Protein isolated from Pinto Durango and Negro 8025 beans were hydrolyzed (120min) with either alcalase® or bromelain and separated into five peptide fractions.

Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to tested analysis,
* The <1kDa pinto Durango-bromelain fraction showed the best inhibition of α-amylase (49.9±1.4%) associated with the causes of hyperglycemia and development of type 2 diabetes.

* Furthermore, the <1kDa pinto Durango-alcalase fraction inhibited both, α-glucosidase (76.4±0.5%), and dipeptidyl peptidase-IV (DPP-IV, 55.3±1.6%) involved in the elevated blood glucose levels.

* Hydrolysates and peptide fractions showed antioxidant capacity (ORAC: 159.6±2.9 to 932.6±1.1mmolTE/g) and nitric oxide inhibition (57.5±0.9 to 68.3±4.2%) that inhibit the overexpression of oxidative stress found in type 2 diabetics.

* Moreover, the hydrolysates and fractions <1 and 1-3kDa were able to increase glucose-stimulated insulin secretion from iNS-1E cells up to 57%, compared to glucose control.

Based on the results, researchers suggest, " Hydrolysates from HTC beans inhibited enzymes related to diabetes management, being the smallest peptides (<1kDa) the most potent. HTC bean could be a source of protein to produce bioactive peptides with potential antidiabetic properties".


Taken altogether, Pinto beans may process antioxidant and anti-diabetes properties, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hard-to-cook bean (Phaseolus vulgaris L.) proteins hydrolyzed by alcalase and bromelain produced bioactive peptide fractions that inhibit targets of type-2 diabetes and oxidative stress by Oseguera-Toledo ME1, Gonzalez de Mejia E2, Amaya-Llano SL. (PubMed)