Herbal Comfrey (Symphytum officinale L.) Speeds Up Wound Healing

Wound healing is the natural process by covering up the damage and injury of the body,
Skin wound healing is a process to repair skin damage and injury.

The process involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.

* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

In most cases, due to the overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.

Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.
The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.

However, the healing process is easier said than done, the complex process in many cases is interrupted by local and systemic factors, including moisture, infection, age, and nutritional status, leading to abnormal cell membrane repair, a major cause of skin scars.

Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.

On finding a potential compound to speed up injury recovery, researchers investigated the wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN).


A randomized clinical double-blind study including 278 patients with fresh abrasions (verum n = 137), among them, 64 patients of up to 20 years of age (verum n = 29, reference product n = 35)with an otherwise identical low-dose preparation (1 % active ingredient; n = 141) used as a control.


According to the results of the examination, after 2-3 days of applied medication exerted a highly significantly and clinically relevantly faster initial reduction of wound size of 49 + or - 19 % versus 29 + or - 13 % per day in favor of verum (p < 5x10(-21))compared to control.
Furthermore, the linear regression time to complete healing was 2.97 days faster with verum compared to control reference.

The physicians rated efficacy as good to very good in 93.4 % of cases, as compared to only 61.7 % in the control.

Moreover, on a scale of 0-100 verum was rated with 84.4 + or - 10.1 points by the patients themselves, compared to the rate of 65.5 in the control.

No adverse effects or problems with drug tolerability occurred. Specifically, the cutaneous reactions throughout the 10-day observation phase.

Based on the findings, researchers said, "Symphytum herb extract can be attributed to distinct wound healing effects, effects that can explicitly be used in paediatry.".


Taken altogether, Comfrey may be considered a remedy for speeding up wound healing, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].[Article in German] byBarna M1, Kucera A, Hladícova M, Kucera M. (PubMed)