Omega-3 Fatty Acids May Be Used for the Treatment of Crohn's disease (CD)

Inflammatory bowel disease is a condition characterized by long term inflammation of the gut. The disease affects over 1.6 million Americans today.

The most common types of IBD are
*Crohn’s disease (CD) is an inflammation of any part of the digestive tract. Most cases of CD affect the tail end of the small intestine.

* Ulcerative colitis is an inflammation of the large intestine.

* Crohn's disease is a type of inflammatory bowel disease caused by inflammation in the gastrointestinal tract.

The exact cause of Crohn's disease is not identified. However, some researchers suggested that people with the compromised immune system and genetic preposition are prone to the disease onset compared to people who do not

The most common symptoms of Crohn's disease are abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

Risk factors of Crohn's disease include aging, family and person history, ethnicity, smoking and long-term use of Nonsteroidal anti-inflammatory medications.

Conventionally, most cases of CD are treated by anti-inflammatory medications, corticosteroids, immunomodulators, and antibiotics.

According to the statistics by Crohn's & Colitis Foundation, the total number of new cases of Crohn's disease diagnosed each year was 10.7 per 100,000 people. In other words, approximately 33,000 new cases are diagnosed each year.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic inflammatory diseases, researchers examined the omega-3 supplementation by oral capsule for patients with Crohn's disease (CD).

The study included a total of 6 patients with CD in remission who participated in this open-label clinical trial and received one bottle (100 ml) of the test formulation (IMARK S®) daily for 28 days. After a 1-month washout period, patients ingested two bottles of the formulation daily for another 28 days.

According to the results of the anthropometric and blood tests,* There were no side effects with the quantity of the injection.
* The application did not alter the body weight and body-mass index in the participants.

* Most importantly, according to the CD activity index, participants showed a decrease in the scores after ingested one bottle of the formulation.

Based on the findings, researchers said, "Supplementation with an omega-3 emulsifying formulation can be safe and useful for maintaining remission in patients with CD and warrants further studies".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of Crohn's disease (CD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Safety of Emulsifying Lipid Formulation Containing Omega-3 Polyunsaturated Fatty Acids for Patients with Crohn's Disease by Yasueda A1, Shinzaki S2, Iijima H2, Mizushima T3, Nishimura J4, Hiyama S5, Ohno S1, Ito T. (PubMed)