Moronic acid, the Anti-Herpes Simplex Virus Supplement

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.


A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.

Anti-viral effects are an act of certain substances to cause the destruction of a virus.

Herpes simplex virus 1 and 2, the 2 members of the herpesvirus family, also are best known as human herpesvirus 1 and 2.

The classification of the virus is based on their likelihood to cause infection. According to WHO(5), in the expression of conventional medicine, there is no cure for the diseases and both HSV-1 and HSV-2 infections are lifelong.

* HSV-1 is mainly transmitted by oral-to-oral contact such as oral herpes.

* HSV-2 is a sexually transmitted infection.

However, both HSV-1 and HSV-2 can cause genital herpes.

According to statistics, approximately 3.7 billion people under age 50 (67%) are infected by HSV-1 and 417 million people aged 15-49 (11%) are infected by HSV-2 globally.

Some patients infected by the virus do not experience any symptoms, however, some may affect by symptoms of painful blisters or ulcers at the site of infection.

The virus is very contagious in the presence of symptoms but they can also transmit to others from virus carriers who experience no symptoms at all.

Moronic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the treatment of infectious diseases, researchers examined
anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.


According to the results from the experimental model,
* Moronic acid was quantitatively a major anti-HSV compound in the ethyl acetate-soluble fraction.
* The effective concentrations for 50% plaque reduction of moronic acid for wild-type HSV type 1 (HSV-1) were 3.9 microgram/ml.

* The oral administration of moronic acid on mice infected cutaneously with HSV-1 three times daily significantly retarded the development of skin lesions and/or prolonged the mean survival times of infected mice without inducing toxicity, compared with the control.


* Moreover, moronic acid suppressed virus yields in the brain more efficiently than those in the skin.

Based on the findings, researchers said, "Moronic acid showed oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity that was consistent with that of the extract".

Taken altogether, moronic acid may be considered an anti-herpes simplex virus supplement, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo by Kurokawa M1, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K. (PubMed)