Ursolic acid Protects Diabetes Against Kidney Injury in Vivo

Diabetic kidney disease is a type of kidney disease caused by diabetes.
Kidneys, a pair of the bean-shaped organ in the human body not only filter out blood but also balances the body fluids by eliminating them and removes them through urinary secretion.

Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.

Kidney disease is a medical condition associated with a gradually reduced function of the kidney.

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.

The most common kidney injury is associated with scar tissues forming in the kidneys.

Renal fibrosis is a condition of abnormal healing of the kidney tissues after injury, caused by the formation of scars in the kidney.

Renal scarring has been found to gradually reduced the renal function, leading to end-stage renal failure, depending on the severity and the area of scarring forming.

Patients at the end stage of renal failure may require dialysis or kidney transplantation.


Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness


Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of kidney diseases, researchers examined the effects of ursolic acid (UA) mitigating renal inflammation, oxidative stress, and fibrosis.

The study included db/db mice that were divided randomly into a diabetic nephropathy (DN) group and a UA treatment group.
According to the analysis,
* UA treatment effectively reduced the body weights and blood glucose levels of db/db mice (p<0.05) as well as the urinary albumin/creatinine ratio (p<0.05).

* UA significantly improved the renal tissue lesions and glomerulosclerosis index of the db/db mice.after treatment (p<0.01).


* UA treatment also significantly lower expression levels of proteins associated with kidney injury and pro-inflammatory cytokines IL-1β and IL-18 in renal tissues, compared to the DN group.

In other words, researchers said, "UA alleviated renal damage in type 2 diabetic db/db mice by downregulating proteins in the ARAP1/AT1R signaling pathway to inhibit extracellular matrix accumulation, renal inflammation, fibrosis, and oxidative stress.".

Taken altogether, ursolic acid may be considered adjunct therapies in the treatment of diabetic kidney injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway by Ma TK#1, Xu L#1,2, Lu LX#1,3, Cao X1, Li X1, Li LL1, Wang X4, Fan QL. (PubMed).