Common Fig or Fig (Ficus carica) Processes Antiproliferative Bioactive Compounds

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Cell division is the process by which a parent cell divides into two or more daughter cells. Normal cell division has a limit cycle before replaced by new cells.

Antiproliferative activity is the process that inhibits cancer cell growth, including inducing apoptosis and cell cycle arrest.

Fig is a species of F. carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches

On finding a potential ingredient for the treatment of cancers, scientists investigated the potential anti-proliferative activity of chemical constituents of the fruits of F. Carica.

According to the tested differentiation, prenylated isoflavone derivatives (1-16) displayed remarkable inhibitory effects against free radical nitric oxide (NO) production with the IC50 values ranging from 0.89 ± 0.05 to 8.49 ± 0.18 μM, comparable to a positive control (hydrocortisone) in inducing oxidative stress to cause DNA damage in healthy cells.

In chemical analysis, all compounds from1-16 also exhibited pronounced antiproliferative activities against a number of human cancer cell lines in vitro, with IC50 values ranging from 0.18 ± 0.03 to 18.76 ± 0.09 μM.

In other words, regular consumption of the fruits of F. carica exerted a preventive effect against diseases associated with inflammation and tumors.


Based on the results, researchers wrote, " the isolation and characterization of these prenylated isoflavone derivatives possessing remarkable anti-inflammatory effects and antiproliferative activities could be meaningful to the discovery of new anti-inflammatory and antitumor agents".

Taken altogether, Common fig or fig may be considered a functional food for the prevention of inflammatory disease and cancers, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Inflammatory and Antiproliferative Prenylated Isoflavone Derivatives from the Fruits of Ficus carica by Liu YP1,2,3, Guo JM1,3, Yan G1,3, Zhang MM1,3, Zhang WH1,3, Qiang L2, Fu YH. (PubMed)