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Monday, August 21, 2017

All About Vitamins: Vitamin B2 Deficiency induced Preventable Preeclampsia in Pregnancy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Riboflavin deficiency is asociated to increased risk factor of  preeclampsia, a renowned institute study proposed.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Preeclampsia is a condition of high blood pressure, sometimes accompanied with water detention in pregnant women.

According to the University Women's Hospital, in the total of 154 pregnant women with increased risk for preeclampsia observed prospectively until delivery, 33.8% among the study population are found to be riboflavin deficiency with the prevalence rate increased to the end of pregnancy.

Among these group of women, risk of developed preeclampsia is increased by 28.8% in compared to women with adequate vitamin B2. Therefore, medication and change of diet are necessary to prevent preeclampsia in induction of certain symptoms, such as gain weigh, headache, abdominal pain,...

Dr. Wacker J, the lead author said, "Riboflavin deficiency should be considered a possible risk factor for preeclampsia. Insufficient concentrations of the riboflavin-derived cofactors flavin adenine dinucleotide and flavin adenine mononucleotide could contribute to the established pathophysiologic changes".

Other researchers also found that pregnant women with vitamin B2 deficiency may interfere with production of Methylenetetrahydrofolate reductase (MTHFR), a critical folate-metabolising enzyme which can only function normally with riboflavin as co-factor.

In vivo, reduced MTHFR activity caused by vitamin B2 deficiency is associated to increased risk of heart disease and stroke of that may influence the pregnancy outcome and mother risk.

Dr.Reilly R, the lead author in the study opinionated , "The evidence is convincing in the case which links this polymorphism with hypertension and hypertensive disorders of pregnancy, particularly preeclampsia. Furthermore, elevated blood pressure was found to be highly responsive to riboflavin intervention specifically in individuals with the MTHFR 677TT genotype.".

Taking altogether, women with history of vitamin B2 deficiency should require to test for levels of Riboflavin during the pregnancy to prevent any unfavorable delivery outcomes.

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