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Wednesday, August 2, 2017

All about Vitamins: Vitamin B2, A Neuroprotective Vitamin

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Vitamin B2 may process an neuroprotective effect against neurological disability in the early stage of dementia

In the study of C57BL/6 female mice (n=56) dived into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), healthy mice receiving PBS and riboflavin; sham treatment 1 (ST1), EAE mice receiving water; sham treatment 2 (ST2), EAE mice receiving sodium acetate buffer; treatment 1 (T1), EAE mice receiving interferon beta-1a (INFβ-1a); treatment 2 (T2), EAE mice receiving riboflavin; treatment 3 (T3), EAE mice receiving INFβ-1a and riboflavin, mice treated with vitamin B2 showed an increased the expression and protein levels in brain-derived neurotrophic factor (BDNF), involved canonical nerve growth compared with the other groups.

The study also found that in daily clinical score, neurological disability was reduced significantly by riboflavinneurological disability compared with that of the controls (P<0.05), through mediation of involved immune response.

In support of the above analysis, Dr. Tripathi AK in the study of "attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro" said," RF pretreatment significantly inhibited cell death and reduced (Lactate Dehydrogenase/secretion) LDH secretion in turning sugar into energy for the cells, compared to that of the UV-B-RF ".

The study also suggested that riboflavin under UV-B irradiation is seen as a modulator of neuroprotective signaling pathway compared RF treated group.

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