All About Vitamins: Vitamin B2 Reduced Risk and Symptoms of Depression

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
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Status of Riboflavin in the blood stream may associate to risk of depression, a renowned study by the  institute proposed.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

According to Jondi-Shapour University of Medical Sciences, patients with depressive symptoms are found to process a elevated levels of serum concentrations of high-sensitive C-reactive protein (hs-CRP) of that indicated lower levels of Riboflavin.

In a cross-sectional study on 98 female clinical nurses, including 45 depressed and 53 nondepressed subjects) using the Beck Depression Inventory in assessed dietary intake of riboflavin using 3-day 24-hour recalls, riboflavin deficiency marginal was more prevalent in depressed subjects.

Dr. Naghashpour M, the lead author said, "(although) higher prevalence of marginal riboflavin deficiency in depressed subjects.... both nondepressed and depressed subjects (addressed) no significant difference between hs-CRP tertiles in dietary intakes of riboflavin, EGRAC, or riboflavin deficiencies".

The promising of the supplement in reduced risk of depression with low cost, prompted a further study of Vitamin B2 in other subjects. 

A cohort of HIV-infected patients conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 y with 26 percent depressed participants (men: 23%; women: 29%), residing in the Kathmandu, Nepal, low intake of riboflavin was associated with an increased risk of depression in women but not in men.

Dr. Poudel-Tandukar K, the lone researcher in the study said, "No clear associations were seen between other B vitamins and depressive symptoms in either sex. Low intake of riboflavin was independently associated with an increased risk of depressive symptoms in all participants and in HIV-infected women".

There is no doubt that intake of vitamin B2 supplement is associated to reduced risk and symptoms of depression but large amount intake should be taken with care.

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Sources
(1) Riboflavin status and its association with serum hs-CRP levels among clinical nurses with depression by Naghashpour M1, Amani R, Nutr R, Nematpour S, Haghighizadeh MH.(PubMed)
(2) Dietary B Vitamins and Depression in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV (POLH) Study by Poudel-Tandukar K1.(PubMed)